A5088025438- Mosquito-borne diseases and control
- interferon and immune responses
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Plant Virus Research Studies
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- Hemophilia Treatment and Research
- Dermatological and COVID-19 studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and Retrovirus Studies
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Biochemical and Molecular Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cancer, Stress, Anesthesia, and Immune Response
Institute of Life Sciences
2021-2024
Regional Centre for Biotechnology
2021-2023
Acute Hemorrhagic conjunctivitis (AHC) is associated with CVA24v. Recently there was a severe outbreak of in months July and August 2023 India. This study emphasizes the identification distinct mutations CVA24v strains, which were isolated during AHC could have potentially played role high transmission India outbreak. A total 71 patients aged 1–75 years comprising 47 males 24 females who attended Ophthalmology department tertiary care hospital easternIndia studied.RNA extracted from all...
Chikungunya virus (CHIKV) has reemerged as a global public health threat. The inflammatory pathways of the renin-angiotensin system (RAS) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) are usually involved in viral infections.
Chikungunya virus (CHIKV) epidemics around the world have created public health concern with unavailability of effective drugs and vaccines. This emphasizes need for molecular understanding host-virus interactions developing targeted antivirals. Microarray analysis was carried out using CHIKV strain (Prototype Indian) infected Vero cells two host isozymes, MAPK activated protein kinase 2 (MK2) 3 (MK3) were selected further analysis. The substrate spectrum both enzymes is indistinguishable...
Purpose The current global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), led to the investigation with clinical, biochemical, immunological, and genomic characterization from patients understand pathophysiology viral infection. Methods Samples were collected six asymptomatic symptomatic SARS-CoV-2-confirmed hospitalized in Bhubaneswar, Odisha, India. Clinical details, biochemical parameters, treatment regimen a hospital; load was...
Aim: In 2022, there was a severe hand, foot and mouth disease (HFMD) outbreak in India. This study focuses on the identification molecular characterization of causative agent. Methods: 51 suspected HFMD patients were examined. Viral RNA from HFMD-positive patients' vesicular extracts sequenced. Phylogenetic analysis carried out for genotype mutation current strains. Results: revealed novel Indian clade CVA16 belonging to B1c. Two consistent mutations, R41H VP3 protein G492T conserved 5′-UTR...
Aims The incidence of DENV-4, the least common serotype Dengue virus, has increased in Americas since 2010. We wanted to explore conserved mutations American DENV-4 strains that may have helped its reemergence.
ABSTRACT Chikungunya virus (CHIKV) has re-emerged as a global public health threat. The inflammatory pathways of RAS and PPAR-γ are usually involved in viral infections. Thus, Telmisartan (TM) with known capacity to block AT1 receptor activate PPAR-γ, was investigated against CHIKV. anti-CHIKV effect TM vitro (Vero, RAW 264.7 cells hPBMCs) vivo (C57BL/6 mice). found abrogate CHIKV infection efficiently (IC50 15.34-20.89µM the Vero respectively). Viral RNA proteins were reduced remarkably...
Background: The current global pandemic of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 led to the investigation with clinical, biochemical, immunological and genomic characterization from patients understand pathophysiology viral infection.Methods: Samples were collected six asymptomatic symptomatic confirmed hospitalized in Bhubaneswar, Odisha, India. Clinical details, biochemical parameters, treatment regime hospital, load was determined RT-PCR, levels cytokines circulating...
Abstract Chikungunya virus (CHIKV) epidemics around the world have created public health concern with unavailability of effective drugs and vaccines. This emphasizes need for molecular understanding host-virus interactions developing targeted antivirals. Microarray analysis was carried out using CHIKV strain (Prototype Indian) infected Vero cells two host isozymes, MK2 MK3 were selected further analysis. Gene silencing drug treatment performed in vitro vivo to unravel role MK2/MK3 infection....
Objectives: Airway compromise is a common and dangerous presenting sign of ACE‐inhibitor–induced angioedema (AIIA). After definitive airway obtained, there minimal evidence‐based data for the effectiveness commonly used medical intervention. While dosing protocols treatment AIIA vary between institutions, they usually contain corticosteroid, H1‐blocker, an H‐2 blocker. The aims study were: (1) Define ACE‐inhibitor‐induced angioedema. (2) Describe upper aerodigestive subsites involvement....
There is no approved antiviral for the management of Chikungunya virus (CHIKV). To develop an drug that can manage both CHIKV and arthritis induced by it, ester conjugate telmisartan (TM) salicylic acid (SA) was synthesized (DDABT1). It showed higher potency (IC50 14.53 μM) a good selectivity index [(SI = CC50/IC50) > 33]. On post-treatment DDABT1, infection inhibited significantly reducing CPE, viral titer, RNA, proteins. Further, time addition experiment revealed >95% inhibition up to 4hpi...
Summary Background The current global pandemic of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 led to the investigation with clinical, biochemical, immunological and genomic characterization from patients understand pathophysiology viral infection. Methods Samples were collected six asymptomatic symptomatic confirmed hospitalized in Bhubaneswar, Odisha, India. Clinical details, biochemical parameters, treatment regime hospital, load was determined RT-PCR, levels cytokines...