A5029052246- Mosquito-borne diseases and control
- interferon and immune responses
- HIV Research and Treatment
- Viral Infections and Vectors
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Head and Neck Cancer Studies
- Viral Infections and Outbreaks Research
- Malaria Research and Control
- Virus-based gene therapy research
- Global Public Health Policies and Epidemiology
- SARS-CoV-2 detection and testing
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- COVID-19 impact on air quality
- Viral Infections and Immunology Research
- Diverse Scientific Research Studies
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
Institute of Life Sciences
2019-2024
Regional Centre for Biotechnology
2021-2023
Mie University
2022
Indian Council of Medical Research
2022
Council of Scientific and Industrial Research
2022
Visva-Bharati University
2021
Government of India
2020
Murshidabad Medical College and Hospital
2019
Medical College and Hospital, Kolkata
2019
Report1 September 2021Open Access Source DataTransparent process Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses Parej Nath Cell Biology and Infectious Diseases Unit, Department Disease Biology, Institute Life Sciences, Bhubaneswar, India School Biotechnology, KIIT University, Search for more papers by this author Nishant Ranjan Chauhan orcid.org/0000-0002-9137-6024 Kautilya Kumar Jena Ankita Datey Molecular Virology Lab, Nilima Dinesh...
Toll like receptor 4 (TLR4), a pathogen-associated molecular pattern (PAMP) receptor, is known to exert inflammation in various cases of microbial infection, cancer and autoimmune disorders. However, any such involvement TLR4 Chikungunya virus (CHIKV) infection yet be explored. Accordingly, the role was investigated towards CHIKV modulation host immune responses current study using mice macrophage cell line RAW264.7, primary cells different origins vivo model. The findings suggest that...
Chikungunya virus (CHIKV) has reemerged as a global public health threat. The inflammatory pathways of the renin-angiotensin system (RAS) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) are usually involved in viral infections.
Being intracellular parasites, viruses require several host cell machineries for effectively replicating their genome, along with virus-encoded enzymes. One of the strategies involves hijacking DDR pathways.
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) is a major global health concern. This virus infects the upper tract and causes pneumonia-like symptoms. So far, few studies have shown alterations in nasopharyngeal (NP) microbial diversity, enrichment of opportunistic pathogens their role co-infections during infections. Therefore, we hypothesized that diversity changes, with increase population pathogens, SARS-CoV2 infection...
Chikungunya virus (CHIKV) epidemics around the world have created public health concern with unavailability of effective drugs and vaccines. This emphasizes need for molecular understanding host-virus interactions developing targeted antivirals. Microarray analysis was carried out using CHIKV strain (Prototype Indian) infected Vero cells two host isozymes, MAPK activated protein kinase 2 (MK2) 3 (MK3) were selected further analysis. The substrate spectrum both enzymes is indistinguishable...
The increase in disease incidences and persistent Chikungunya virus (CHIKV)-induced arthritis have been a huge burden on public health globally. In the absence of specific antivirals or vaccines, it is essential to continue efforts develop effective anti-CHIKV strategies.
Abstract Introduction The emergence of drug resistance and cross-resistance to existing drugs has warranted the development new antivirals for Herpes simplex viruses (HSV). Hence, we have designed this study evaluate anti-viral activity 1-[(2-methyl benzimidazole-1-yl) methyl]-2-oxo-indolin-3-ylidene] amino] thiourea (MBZM-N-IBT), against HSV-1. Method Molecular docking was performed assess affinity MBZM-N-IBT HSV-1 targets. This validated by plaque assay, estimation RNA protein levels as...
The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a serious pandemic has altered global socioeconomic dynamics. wide prevalence, high death counts, and rapid new variants urge for establishment research infrastructure to facilitate development efficient therapeutic modalities preventive measures. In agreement with this, SARS-CoV-2 strains were isolated from patient swab samples collected during first COVID-19 wave in Odisha, India. viral isolates adapted...
ABSTRACT Japanese encephalitis, caused by encephalitis virus (JEV) is a vector born disease for which no specific therapeutics are available yet. Binding of angiotensin II (Ang II) to type 1 (AT1) receptor induces release inflammatory cytokines associated with viral encephalitis. Accordingly, Ang blockers (ARBs) have been proposed manage Since Telmisartan (TM, antagonist AT1 and agonist PPARγ) has relatively better brain access than other ARBs, this investigation aims evaluate its anti-JEV...
Background: Hypertension is a major public health problem in India and considered as silent killer disease. The national program for prevention control of cancer, diabetes, CVD stroke (NPCDCS) recommended opportunistic screening hypertension at all levels facility. present study was conducted with the objectives to estimate magnitude among General OPD attendees aged 18 years above tertiary care hospital district West Bengal find out factors influencing them.Methods: based observational,...
Abstract Activation of type 1 interferon response is extensively connected with the antiviral immunity and pathogenesis autoimmune diseases. Here, we found that IRGM, whose deficiency linked genesis several disorders, a master negative regulator response. Mechanistically, show IRGM interacts nucleic acid sensor proteins, including cGAS RIG-I, mediates their autophagic degradation to restrain activation signaling. Further, maintains mitophagy flux, its results in accumulation defunct leaky...
Abstract Viruses utilize a plethora of strategies to manipulate the host pathways and hijack its machineries for efficient replication. Several DNA as well handful RNA viruses are reported interact with proteins involved in damage responses (DDR). As DDR have never been explored Alphaviruses, this investigation intended determine importance CHIKV infection through vitro, vivo ex models. The study reveals that activates Chk2 Chk1 associated signaling increases by 95%. Inhibition both ATM-ATR...
ABSTRACT Chikungunya virus (CHIKV) has re-emerged as a global public health threat. The inflammatory pathways of RAS and PPAR-γ are usually involved in viral infections. Thus, Telmisartan (TM) with known capacity to block AT1 receptor activate PPAR-γ, was investigated against CHIKV. anti-CHIKV effect TM vitro (Vero, RAW 264.7 cells hPBMCs) vivo (C57BL/6 mice). found abrogate CHIKV infection efficiently (IC50 15.34-20.89µM the Vero respectively). Viral RNA proteins were reduced remarkably...
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a major global health concern. This infects the upper tract and causes pneumonia-like symptoms. So far, few studies have shown that infections alter nasopharyngeal (NP) microbiome diversity enrich opportunistic pathogens. In this study, we sequenced 16S rRNA variable regions, V1 through V9, extracted from NP samples of control COVID-19 (symptomatic...
Abstract Chikungunya virus (CHIKV) epidemics around the world have created public health concern with unavailability of effective drugs and vaccines. This emphasizes need for molecular understanding host-virus interactions developing targeted antivirals. Microarray analysis was carried out using CHIKV strain (Prototype Indian) infected Vero cells two host isozymes, MK2 MK3 were selected further analysis. Gene silencing drug treatment performed in vitro vivo to unravel role MK2/MK3 infection....
There is no approved antiviral for the management of Chikungunya virus (CHIKV). To develop an drug that can manage both CHIKV and arthritis induced by it, ester conjugate telmisartan (TM) salicylic acid (SA) was synthesized (DDABT1). It showed higher potency (IC50 14.53 μM) a good selectivity index [(SI = CC50/IC50) > 33]. On post-treatment DDABT1, infection inhibited significantly reducing CPE, viral titer, RNA, proteins. Further, time addition experiment revealed >95% inhibition up to 4hpi...
Ethnopharmacological relevance: Cameroon is one of the sub-Saharan African countries affected by Chikungunya virus (CHIKV). With absence approved treatment, this disease represents globally a major public health concern. Thus, plant based antiviral drug promises more potential alternative to curb burden CHIKV. Aim Study: The aims study was determine effect extract on life cycle virus.Method: An ethnobotanical survey conducted in some regions Cameroon, led identification nine medicinal plants...
inflammasome leading to increase production of IL-1beta and Il-18 cytokines in AVH patients indicated the role Th1 response recovery (Thakur et al., 2022).HEV found be associated with 30.4% ALF undiagnosed cases.Immunohistochemistry along molecular testing FFPE biopsies might useful diagnosis liver failure cases (Ratho 2018).Detection HEV RNA antigen placental tissues extra-hepatic replication HEV.Placental tissue necrosis significant rise level infected pregnant women contributing...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a major global health concern. This infects the upper tract and causes pneumonia-like symptoms. So far, few studies have shown alterations in nasopharyngeal (NP) microbial diversity, enrichment of opportunistic pathogens their role co-infections during infections. Therefore, we hypothesized that diversity changes, with increase population pathogens,...
Abstract Emergence of SARS-CoV-2 as a serious pandemic has altered the global socioeconomic dynamics. The wide prevalence, high death counts and rapid emergence new variants urge for establishment research infrastructure to facilitate development efficient therapeutic modalities preventive measures. In agreement with this, five SARS-CoV2 strains (ILS01, ILS02, ILS03, ILS15 ILS24) four different clades (19A, 19B, 20A 20B) were isolated from patient swab samples collected during 1 st COVID-19...