A5044775184- Hip and Femur Fractures
- Bone and Joint Diseases
- Hip disorders and treatments
- MicroRNA in disease regulation
- Bone fractures and treatments
- Bone health and osteoporosis research
- Pelvic and Acetabular Injuries
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Magnesium in Health and Disease
- Biomarkers in Disease Mechanisms
- Parathyroid Disorders and Treatments
- Meta-analysis and systematic reviews
- Data Quality and Management
- Medication Adherence and Compliance
- COVID-19 Impact on Reproduction
- Artificial Intelligence in Healthcare and Education
- Trauma and Emergency Care Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Innovation Policy and R&D
- Diabetes Management and Education
- Biomedical Text Mining and Ontologies
- Biomedical and Engineering Education
- IL-33, ST2, and ILC Pathways
- Chronic Disease Management Strategies
Tongji University
2019-2025
Hangzhou Hospital of Traditional Chinese Medicine
2024
Bone mesenchymal stem cells (BMSCs)-derived exosomes (Exos) play important roles in osteoporosis, while the regulation of microRNA (miR)-21-5p remains unclear. The BMSCs-derived were isolated from femoral bone marrow trauma patients, which then used to stimulate human osteoblasts (hFOB1.19 cells). miR-21-5p mimic or inhibitor was transfected into BMSCs overexpress knockdown miR-21-5p. functions osteoporosis assessed by cell counting kit-8 (CCK-8) assay, alkaline phosphatase (ALP) staining...
Introduction: The relationships between calcium, bone mineral density, and hip fracture have been studied for a long time, but there are still different opinions on the matter. aim of this study was to decipher relationship these factors from National Health Nutrition Examination Survey (NHANES) data. Methods: After we performed data cleaning obtained NHANES data, used multiple imputation obtain complete conducted an analysis variables. First, by using multivariate linear regression models,...
Gout commonly manifests as a painful, self-limiting inflammatory arthritis. Nevertheless, the understanding of and immune responses underlying gout flares remission remains ambiguous. Here, based on single-cell RNA-Seq an independent validation cohort, we identified potential mechanism flare, which likely involves upregulation HLA-DQA1+ nonclassical monocytes is related to antigen processing presentation. Furthermore, Tregs also play essential role in suppressive capacity during remission....
Background Although favorable outcomes have been reported with radiofrequency ablation (RFA) for secondary hyperparathyroidism (SHPT), the long-term efficacy remains insufficiently investigated. Purpose To evaluate and safety of US-guided percutaneous RFA in patients SHPT undergoing dialysis to identify possible predictors associated treatment failure. Materials Methods This retrospective study included consecutive at least one enlarged parathyroid gland accessible who were seven tertiary...
The absolute number of femoral neck fractures (FNFs) is increasing; however, the prediction traumatic head necrosis remains difficult. Machine learning algorithms have potential to be superior traditional methods for necrosis.The aim this study use machine construct a model analysis risk factors and osteonecrosis (ONFH) in patients with FNF after internal fixation.We retrospectively collected preoperative, intraoperative, postoperative clinical data 4 hospitals Shanghai followed up more than...
Background Healthcare workers' relationship with industry is not merely an agent mediating between consumer and vendor, but they are also inventors of the interventions exist to deliver. Driven by background digital health era, scientific research technological (Sci-tech) innovation in medical field becoming more closely integrated. However, scholars shed little light on Sci-tech relevance evaluate performance healthcare organizations, a distinctive feature organizations' era. Methods...
Abstract Objectives Alcohol consumption is one of the leading factors contributing to premature osteopenia. MicroRNA (miRNA) coordinates a cascade anabolic and catabolic processes in bone homeostasis dynamic vascularization. The aim was investigate protective role miR‐4286 alcohol‐induced loss its mechanism. Materials Methods effect alcohol on mesenchymal stem cells (BMSCs) human umbilical vein endothelial (HUVECs) explored via multiple vitro assays, including cell proliferation, QPCR,...
Acute kidney injury (AKI) is a common complication associated with significant morbidity and mortality in high-energy trauma patients. Given the poor efficacy of interventions after AKI development, it important to predict before its diagnosis. Therefore, this study aimed develop models using machine learning algorithms risk patients femoral neck fractures. We developed machine-learning Medical Information Mart from Intensive Care (MIMIC)-IV database. was predicted 10 predictive three-time...
Translate General Adherence Scale (GAS) into Chinese and test its psychometric properties in middle-aged elderly type 2 diabetes (T2D) patients using insulin the Han people of urban China.We translated GAS established (GAS-C). 136 T2D subjects were selected for testing GAS-C's reliability validity, which 100 study retested with GAS-C two weeks later. The other 200 performing Confirmatory Factor Analysis(CFA). ceiling effect floor data checked.No was lost our research. In exploratory factor...
Few people have reported whether there are sex differences in blood lipids and lipid ratios type 2 diabetic foot (T2DF) patients China. This study attempts to identify the contribution sex-specific these patients.
Background The significant impact of digital health emerged prominently during the COVID-19 pandemic. Despite this, there is a paucity bibliometric analyses focusing on technologies within field patents. Patents offer wealth insights into technologies, commercial prospects, and competitive landscapes, often undisclosed in other publications. Given rapid evolution industry, safeguarding algorithms, software, advanced surgical devices through patent systems imperative. system simultaneously...
Our study aimed to reveal the relationship of maternal pentraxin 3 (PTX3)'s serum concentrations in early pregnancy with gestational diabetes mellitus (GDM) and explore its potential prediction GDM.Totally 824 pregnant women were enrolled divided into a GDM group normal glucose tolerance (NGT) group, whose fasting PTX3 levels, plasma insulin collected. The beta cell function index quantitative sensitivity check (QUICKI) was calculated homeostatic model assessment resistance (HOMA-IR) used...
Femoral neck fracture (FNF) accounts for approximately 3.58% of all fractures in the entire body, exhibiting an increasing trend each year. According to a survey, 1990, total number hip men and women worldwide was 338,000 917,000, respectively. In China, FNFs account 48.22% fractures. Currently, many studies have been conducted on postdischarge mortality risk patients with FNF. However, there no definitive in-hospital or its influencing factors severe FNF admitted intensive care unit.
<sec> <title>BACKGROUND</title> The significant impact of digital health emerged prominently during the COVID-19 pandemic. Despite this, there is a paucity bibliometric analyses focusing on technologies within field patents. Patents offer wealth insights into technologies, commercial prospects, and competitive landscapes, often undisclosed in other publications. Given rapid evolution industry, safeguarding algorithms, software, advanced surgical devices through patent systems imperative....
<sec> <title>BACKGROUND</title> Figures are an important form of expressing results commonly found in medical papers and make data easy to read compare. The quality graphs original has improved western journals. However, some figures fail correctly express the a paper. Additionally, graph application not been assessed journals outside countries. </sec> <title>OBJECTIVE</title> To determine frequency types used Chinese academic evaluate papers. <title>METHODS</title> A total 783 were surveyed...
Background . Hip fracture is one of the major risk factors global mortality and disability. The aim this study was to map pattern intertrochanteric femoral fractures in China, providing a pilot national dataset basis for medical policy proposals. Methods A multistage probability sampling strategy applied baseline survey. Thirty provinces mainland China were included standardized questionnaire survey conducted collect information about basic characteristics such as age, working seniority,...
<sec> <title>BACKGROUND</title> Femoral neck fracture (FNF) accounts for approximately 3.58% of all fractures in the entire body, exhibiting an increasing trend each year. According to a survey, 1990, total number hip men and women worldwide was 338000 917000, respectively. In China, FNFs account 48.22% fractures.Currently, large studies have been conducted on postdischarge mortality risk patients with FNF. However, there no definitive in-hospital or its influencing factors such severe FNF...
<sec> <title>BACKGROUND</title> The absolute number of femoral neck fractures (FNFs) is increasing; however, the prediction traumatic head necrosis remains difficult. Machine learning algorithms have potential to be superior traditional methods for necrosis. </sec> <title>OBJECTIVE</title> aim this study use machine construct a model analysis risk factors and osteonecrosis (ONFH) in patients with FNF after internal fixation. <title>METHODS</title> We retrospectively collected preoperative,...