A5100723430- Systemic Lupus Erythematosus Research
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- Venomous Animal Envenomation and Studies
- Schizophrenia research and treatment
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Structural Characterization
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Healthcare and Venom Research
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- 14-3-3 protein interactions
- Extraction and Separation Processes
- CCD and CMOS Imaging Sensors
- Advancements in Battery Materials
- vaccines and immunoinformatics approaches
- Psychosomatic Disorders and Their Treatments
- Venous Thromboembolism Diagnosis and Management
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Nicotinic Acetylcholine Receptors Study
- Pediatric health and respiratory diseases
Qingdao University
2016-2023
Affiliated Hospital of Qingdao University
2016-2023
Beijing University of Technology
2023
University of Virginia
2015-2022
Center for Neuroscience and Regenerative Medicine
2021
Wuhan University
2008-2013
State Key Laboratory of Virology
2009
Guangzhou Psychiatric Hospital
2008
The misuse of antibiotics has led our age to a dangerous edge, as antibiotic-resistant pathogens appear evolve more quickly than are invented. Thus, new agents treat bacterial infection badly needed. Cationic host defense peptides on the first line system and thought be good candidates for treating infection. Here, novel cationic peptide, mucroporin, was cloned characterized from venom Lychas mucronatus. MIC Staphylococcus aureus 25 microg/ml, including pathogens. Based molecular template...
The pace of resistance against antibiotics almost exceeds that the development new drugs. As many bacteria have become resistant to conventional antibiotics, drugs or drug resources are badly needed combat antibiotic-resistant pathogens, like methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobial peptides, rich sources existing in nature, able effectively kill multidrug-resistant pathogens. Here, imcroporin, a antimicrobial peptide, was screened and isolated from cDNA library...
Hepatitis B virus (HBV) is a noncytopathic human hepadnavirus that causes acute, chronic hepatitis and hepatocellular carcinoma (HCC). As the clinical utility of current therapies limited, new anti-HBV agents sources for such are still highly sought after. Here, we report Mucroporin-M1, scorpion venom-derived peptide, reduces amount extracellular HBsAg, HBeAg, HBV DNA productions HepG2.2.15 cells in dose-dependent manner inhibits capsid DNA, intracellular RNA replication intermediates Core...
NLRP3 inflammasome regulates T cell responses. This study examined the roles of activation in regulation follicular helper (Tfh) cells during humoral response to dependent antigens and systemic lupus erythematosus (SLE).NLRP3 Tfh was studied B6, MRL/lpr NZM2328 mice SLE patients healthy controls using a fluorescence-labelled caspase-1 inhibitor probe. MCC950, selective NLRP3, used investigate relation between germinal centre (GC) reaction, Ab responses immunisation, autoantibody...
<ns4:p>Anti-dsDNA antibodies are the most studied of lupus-related autoantibodies. The dogma is that these important autoantibodies in systemic lupus erythematosus. In this review, evidence presented to show (as measured by modern clinical laboratories) not diagnosis erythematosus, and limited value correlation predicting disease flares. addition, they likely be initiating nephritis. Thus, several pervasively held beliefs on anti-dsDNA valid. We suggest should considered as just one many...
Objectives The generation of systemic lupus erythematosus (SLE)-related autoantibodies have been shown to be T cell dependent and antigen driven with HLA-DR restriction. In this study, the initiating antigen(s) mechanism autoantibody diversification were investigated. Methods epitopes (T-epitopes) SmD1 (SmD) mapped by T-T hybridomas generated from DR3 + AE 0 mice immunised SmD overlapping peptides. TCRs reactive sequenced. core determined. Bacterial mimics identified bioinformatics. Sera...
BACKGROUND:The aim of this study was to investigate the expression CLDN1 in non-small cell lung cancer (NSCLC) and its mechanism action cisplatin resistance. MATERIAL AND METHODS:A total 55 patients with NSCLC admitted our hospital between October 2013 2015 were included. tissues tumor-adjacent (≥5 cm from tumor edge) collected. Among patients, 37 had adenocarcinoma 18 squamous carcinoma. Quantitative real-time polymerase chain reaction used determine mRNA expression, protein examined using...
Little is known about the risk factors for suicide among psychiatric inpatients in China. In this study we identified of at Guangzhou Psychiatric Hospital. All who died by during 1956–2005 period were included study. Using a case‐control design, 64 with schizophrenia compared matched controls. The results indicate that rate was 133.1/100,000 admissions (95%CI 103.4–162.9). There no significant differences method, location, or time between male and female inpatients. number hospitalizations...
Neprilysin has been reported to be a major beta-amyloid peptide (Aβ)-degrading enzyme. The decreased expression and activity of it may contribute the development Alzheimer's disease by promoting accumulation Aβ. We used denaturing high-performance liquid chromatography screen neprilysin gene (NEP) for single nucleotide polymorphisms (SNPs) in 257 Chinese sporadic patients 242 cognitive normal controls. As result, eight novel one known SNP were identified. Three them, −204G→C promoter region,...
Acotiamide is a new prokinetic drug that used to treat functional dyspepsia (FD). A sensitive and specific LC–MS-MS method has been developed validated for the analysis of acotiamide in rat plasma. The assay involved simple protein precipitation (PPT) step with methanol–acetonitrile (50:50, v/v) gradient elution using mobile phase consisting water containing 0.1% formic acid methanol acid. analytes were chromatographed on reverse-phase Agilent Zorbax XDB C18 column (2.1 mm × 50 mm, 3.5 μm)...
Background. Lung cancer is considered to be the second most aggressive and rapidly fatal after breast cancer. Necroptosis, a novel discovered pattern of cell death, mediated by Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), 3 (RIPK3), Mixed Lineage Kinase Domain Like Pseudokinase (MLKL). Methods. For purpose developing prognostic model, Least absolute shrinkage selection operator (LASSO) Cox regression analysis was conducted. Using Pearson’s correlation analysis, we...
HLA-DR3 (DR3) is one of the dominant HLA-DR alleles associated with systemic lupus erythematosus (SLE) susceptibility. Our previous studies showed multiple intramolecular DR3 restricted T cell epitopes in Smith D (SmD) protein, from which we generated a non-homologous, bacterial epitope mimics library. From this library identified ABC 247-261 Mimic as new transporter ATP-binding protein Clostridium tetani . It activated and induced autoreactive SmD 66-80 -specific cells autoantibodies to...
Objective To explore relationship of G308A polymorphism in the tumor necrosis factor a (TNF-α) gene and TNF-α serum level with schizophrenia. Methods The TNFa was tested by PCR-based RFLP 155 schizophrenic family trios from Guangdong Province polymerase chain reaction restriction fragment length techniques, TNF-alpha ELISA. Results Haplotype relative risk revealed that transmitted A allelic frequency patients significantly higher than their parents (27.1% vs 15.0%, P< 0.01), also...
<h3>Background</h3> The presence of complex autoantibodies (auto-Abs) is a hallmark SLE. most cited hypotheses for their origin are the "B cell epitope mimicry hypothesis between SmB and EBV" "particle hypothesis". Neither adequate to explain characteristics SLE–related Abs. Our studies showed that HLA-DR3 DR2 transgenic mice in contrast DR4 respond well SmD Ro60 with DR3 being best responders. In addition, certain bacterial mimics T epitopes were shown induce auto-Abs SnRNP Ro60/La....
Recycling of spent lithium-ion batteries (LIBs) cathode materials has become a hot research area owing to limited resources, environmental problems, and strong global demand for LIBs raw materials. However, among multiple types materials, the recycling xLi2MnO3·(1-x)LiMO2 not been studied remains challenging. Herein, in this work, green efficient process developed simultaneous recovery Li, Ni, Mn from by an ammonium sulfate roasting method. By optimizing parameters, such as temperature 450...
Objective To evaluate the efficacy and safety of risperidone long-acting injection (RLAI) in maintenance treatment for schizophrenia.Methods This was an open label, single arm multi-center study.Two hundred schizophrenic patients switching from other antipsychotics accepted two-week interval injections RLAI nine months.The dosages were 25.0 mg, 37.5 mg or 50.0 every two weeks.The assessed with Positive Negative Syndrome Scale (PANSS), Clinical Global Impression (CGI) rating scale, etc.Safety...