A5100337116- Autophagy in Disease and Therapy
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Aortic Disease and Treatment Approaches
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- Mesenchymal stem cell research
- Esophageal and GI Pathology
- Peptidase Inhibition and Analysis
- Vascular Procedures and Complications
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- interferon and immune responses
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Vitamin C and Antioxidants Research
- Pancreatic and Hepatic Oncology Research
- Vitamin K Research Studies
- Cancer Mechanisms and Therapy
- Blood groups and transfusion
- Parathyroid Disorders and Treatments
- Coronary Interventions and Diagnostics
First Affiliated Hospital of Xi'an Jiaotong University
2012-2024
National Clinical Research Center for Digestive Diseases
2024
Changchun University of Chinese Medicine
2024
North Sichuan Medical University
2017-2024
Central South University
2024
Chongqing Medical University
2023
Xi'an Jiaotong University
2015-2022
Jinzhou Medical University
2022
Dalian Medical University
2021
The University of Texas Health Science Center at Houston
2020
Paired-box 6 (PAX6) is an important transcription factor required for the function of human neuroectodermal epithelial tissues. Previous studies have suggested that it also expressed in several types tumors and has oncogenic role. However, little known about its role non-small cell lung cancer (NSCLC). Here, we found PAX6 expression levels were upregulated tissues correlated with poor clinical outcomes. overexpression significantly promoted NSCLC epithelial-to-mesenchymal transition (EMT)...
Metabolic syndrome (MetS) is a widespread and multifactorial disorder, the study of its pathogenesis treatment remains challenging. Autophagy, an intracellular degradation system that maintains cellular renewal homeostasis, essential for maintaining antimicrobial defense, preserving epithelial barrier integrity, promoting mucosal immune response, intestinal regulating gut microbiota microbial metabolites. Dysfunctional autophagy implicated in pathological mechanisms MetS, involving insulin...
Although the epithelial-mesenchymal transition (EMT) is a normal process that occurs during development, it thought to be associated with cancer progression and metastasis. Emerging evidence links mesenchymal stem cells (MSCs) in tumor microenvironment occurrence of EMT progression. In this study, human breast cell line MCF7 was co-cultured adipose-derived MSCs (hAD-MSCs) transwell system. Co-cultured were analyzed for changes cellular morphology, markers, protein expression characteristics....
Colon cancer is one of the deadliest cancers worldwide because its metastasis to other essential organs. Metastasis colon involves a complex set events, including epithelial-to-mesenchymal transition (EMT) that increases invasiveness tumor cells. Here, we show xeroderma pigmentosum group E (XPE) gene product, damaged DNA-binding protein (DDB)-2, downregulated in high-grade cancers, and it plays dominant role suppression EMT Depletion DDB2 promotes mesenchymal phenotype, whereas expression...
Persistent Fusobacterium nucleatum infection is associated with the development of human colorectal cancer (CRC) and promotes tumorigenicity, but underlying mechanisms remain unclear. Here, we reported that F. promoted tumorigenicity CRC, which was nucleatum-induced microRNA-31 (miR-31) expression in CRC tissues cells. inhibited autophagic flux by miR-31 through inhibiting syntaxin-12 (STX12) increased intracellular survival nucleatum. Overexpression cells their targeting eukaryotic...
BACKGROUND:The aim of this study was to investigate the expression CLDN1 in non-small cell lung cancer (NSCLC) and its mechanism action cisplatin resistance. MATERIAL AND METHODS:A total 55 patients with NSCLC admitted our hospital between October 2013 2015 were included. tissues tumor-adjacent (≥5 cm from tumor edge) collected. Among patients, 37 had adenocarcinoma 18 squamous carcinoma. Quantitative real-time polymerase chain reaction used determine mRNA expression, protein examined using...
In previous studies from other labs it has been well demonstrated that the ectopic expression of c-Myc in mammary epithelial cells can induce epithelial-mesenchymal transition (EMT), whereas our pilot experiment, epithelial-like morphological changes were unexpectedly observed c-Myc-expressing pig fibroblasts [i.e., porcine embryonic (PEFs) and dermal (PDFs)] mesenchymal stem cells, suggesting same gene is entitled to trigger EMT mesenchymal-epithelial (MET) fibroblasts. This prompted us...
Abstract Amplification of the MET oncogene is associated with poor prognosis, metastatic dissemination, and drug resistance in many malignancies. We developed a method to capture characterize circulating tumor cells (CTC) expressing c-MET using ferromagnetic antibody. Immunofluorescence was used for c-MET, DAPI, pan-CK, excluding CD45+ leukocytes. The assay validated appropriate cell line controls spiked into peripheral blood collected from healthy volunteers (HV). In addition, analyzed...
Objective Matrix Gla protein (MGP) is a potent calcification inhibitor. Mgp-/- mice display increased proportion of brown adipose tissue. However, whether MGP involved in fat metabolism remains unclear. This study aims to investigate the involvement. Methods Expression adipocyte differentiation markers was examined by RT-qPCR. Adipocyte formation assessed Oil Red staining. Serum triglyceride, cholesterol, and desphosphorylated-uncarboxylated (dp-ucMGP) were quantified ELISA. Visceral...
Abstract Hepatocellular carcinoma in China accounts for half of the world's incidence. Both epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs) are thought to be involved tumor malignant progression. However, relationship between EMT CSCs is still unclear. Bioinformatics analysis was performed evaluate CSCs. The CSC regulatory mechanism investigated through Transwell, wound‐healing, sphere formation, colony‐forming, western blotting assays. Immunofluorescence...
Matrix Gla protein (MGP) is an extracellular responsible for inhibiting mineralization. MGP inhibits osteoblast mineralization and bone formation by regulating the deposition of matrix. However, Mgp-/- mice display osteopenic phenotype. To explain this contradiction, we investigated role in osteoclastogenesis, other side remodeling. We found that expression markedly increased osteoclastic commitment. Osteoclast differentiation resorption are accelerated depletion while suppressed...
// Han 1, 2 , Jing Li 1 Xiuyan Feng 3 Hui Zhou Shanchun Guo 4, 5 and Weiqiang Key Laboratory of Environmental Pollution Microecology Liaoning Province, Shenyang Medical College, Huanggu, City, Province 110034, P. R. China Department Biochemistry Molecular Biology, The Second Affiliated Hospital Heping, 110002, 4 RCMI Cancer Research Center, Xavier University Louisiana, New Orleans, LA 70125, USA Chemistry, Correspondence to: Zhou, email: zhouwq@hotmail.com Keywords: SAHA, autophagy,...
Magnetic compression anastomosis (MCA) has been used to achieve anastomotic recanalization treat severe stenosis or atresia of the biliary tract and digestive [1] [2] [3] [4]. Herein, we report successful by means MCA in a case rectal atresia.
Abstract Gastroesophageal reflux disease (GERD) is associated with sleep disturbances. However, mechanisms underlying these interactions remain unclear. Male acute and chronic deprivation (SD) mice were used for this study. Mice in the SD group exhibited anxiety‐ depression‐like behaviors. We further performed high‐throughput genome sequencing bioinformatics analysis to screen featured differentially expressed genes (DEGs) esophageal tissue. The group, comprised 25 DEGs including 14...
Abstract Background and Aim Most patients with gastric tumors precancerous lesions are asymptomatic, which often results in delayed diagnosis treatment. Compared conventional gastroscopy capsule endoscopy, magnetic‐controlled endoscopy is a non‐invasive, effective, cost‐efficient diagnostic modality for examination. We retrospectively investigated as screening tool gastrointestinal (particularly lesions) asymptomatic individuals. Methods In this retrospective study, 1757 who voluntarily...
Resistance to EGFR-targeted therapy is a major obstacle in hepatocellular carcinoma (HCC) treatment, but its underlying mechanism remains unclear. Autophagy plays vital role antitumour treatment. Our previous study suggested that p57 associated with autophagy and cisplatin resistance. The present aimed investigate whether can enhance the sensitivity of HCC cells Erlotinib (Er)/Cetuximab(C-225) further explore potential mechanisms Er/C-225 were transfected pIRES2-EGFP-p57 pIRES2-EGFP-nc,...
Ras GTPases are powerful drivers for tumorigenesis, but directly targeting treating cancer remains challenging. The growth and transforming activity of the aggressive basal-like breast (BLBC) driven by N-Ras. To target N-Ras in BLBC, this study screened existing pharmacologically active compounds new ability to induce degradation, which led identification flunarizine (FLN), previously approved migraine epilepsy. FLN-induced degradation was not affected a 26S-proteasome inhibitor. Rather, it...
Chronic pancreatitis (CP) is a major risk factor of pancreatic ductal adenocarcinoma (PDAC). How CP promotes oncogenesis remains unclear. A characteristic feature PDAC its prominent desmoplasia in the tumor microenvironment, composed activated fibroblasts and macrophages. Macrophages can be characterized as M1 or M2, with tumor-inhibiting -promoting functions, respectively. We reported that Gremlin 1 (GREM1), key pro-fibrogenic factor, upregulated stroma CP. The current study aimed to...
Journal Article Comparison of radiation dose to operator between transradial and transfemoral coronary angiography with optimised protection: a phantom study Get access Huiliang Liu, Liu Division Cardiology, General Hospital Chinese People's Armed Police Forces, No. 69, Yongding Road, Haidian District, Beijing 100039, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Zhigeng Jin, Jin * *Corresponding author: lwgjzg@sina.com Limin Jing Radiation Protection...