Breast cancer is a heterogeneous disease with wide range of clinical behaviour. Tumour angiogenesis and metastasis have been considered as prognostic markers the breast carcinoma, c-Met, transmembrane receptor tyrosine kinase has implicated in both these processes tumour progression. This study was conducted to elucidate c-Met downstream signalling pathways correlate assessed by microvessel density (MVD) other parameters including lymph node metastases. Microvessel endothelial cell (CD34)...

Background: The diagnosis of parotid swelling is challenging and investigations like imaging needle aspiration cytology are helpful. objective this study was to determine the diagnostic accuracy fine (FNAC) as compared histopathology in gland swelling.Methods: It a descriptive cross sectional carried out Department ENT-Head & Neck Surgery, Tribhuvan University Teaching Hospital, Institute Medicine, Kathmandu by reviewing medical record charts patients who had undergone surgery for...

Introduction Fine needle aspiration cytopathology (FNAC) is widely used for the stratification of thyroid nodules. Objective The objective present study to validate FNAC reporting based on Bethesda System Reporting Thyroid Cytopathology (TBSRTC) at our institution and calculate risk malignancy in each category. Methods This was a descriptive cross-sectional conducted jointly Department Ear, Nose Throat Pathology period 1.5 years (May 2018 November 2018). All cases presenting with swelling...

MPL (myxoid pleomorphic liposarcoma) is an uncommon type of liposarcoma that affects mostly children and infants. Its aggressive behavior tendency to recur warrant complete excision despite the challenges troublesome locations.A 12-month-old infant presented with insidious onset noisy breathing respiratory distress not relieved by supplemental oxygen via face mask. Examination revealed dullness decreased air entry on left chest. Computed Tomographic (CT) scan showed a large solid mass...

Mucormycosis is a rare invasive fungal infection with high mortality rate caused by members of the family Mucoraceae. It mainly affects immunocompromised hosts such as poorly controlled diabetes mellitus, previous solid organ transplant, high-dose steroids, and hematologic malignancy. The most common sites disease are rhinocerebral, skin, lungs, gastrointestinal tract. In this era COVID-19 infection, there has been significant rise in mucormycosis predominantly reported from southeast. We...

Background: Cutaneous granulomas comprise a wide spectrum of diseases that are frequently encountered. Since clinical assessment alone is insufficient in most the cases, skin biopsies basic requisite evaluating these lesions. Histopathological examination, although helpful deciding nature and etiology maybe noncontributory some thus requiring further ancillary tests such as microbial culture, polymerase chain reaction. Materials Methods: This prospective cross sectional study enrolled 109...

Abstract Pediatric giant cell glioblastoma, a highly malignant and lethal tumor, can only be distinguished from glioblastoma multiforme histologically. Though it is said to have better prognosis, adequate evidence in favor lacking. Early diagnosis with gross total resection adjuvant chemotherapy might increase the survival period.

Paragonimiasis, or Oriental lung fluke is a parasitic infestation seen in Asia, Africa and South America which spread by the consumption of crabs crayfish. To date four cases have been reported from Nepal. Here, we report case paragonimiasis young male Kathmandu valley who presented with symptoms fever, on off for 1 month, shortness breath cough. He was found to pleural effusion. Sputum examination did not reveal acid fast bacilli, However, based clinical features, he started antitubercular...

Paraganglioma of the urinary bladder is unusual and reported rarely. The patient usually presents with complaint hematuria fluctuating blood pressure.We discuss case a 21-year old male, who had been experiencing gross hematuria, was found to have mass on ultrasonography. Further evaluation contrast-enhanced computerized tomography (CECT) revealed an irregular soft tissue density endophytic arising from left posterior wall bladder. histopathological examination excised suggestive tumor neural...

Sarcina ventriculi is a gram positive bacteria which has been reported in patients with delayed gastric emptying as well association cases of ulcer and carcinoma. Although it frequently veterinary cause fatal diseases, exact pathogenesis humans yet to be identified. We report here, case an elderly male who presented hematemesis following upper gastrointestinal endoscopy was done revealed. Histopathological examination revealed ulcer.

Sarcina ventriculi is a species of Gram-positive bacteria which has been reported in patients with delayed gastric emptying as well association cases ulcer and carcinoma. Although it frequently veterinary cause fatal diseases, the exact pathogenesis humans yet to be identified. We report here case an elderly male who presented haematemesis following upper gastrointestinal endoscopy was done revealed. Histopathological examination revealed S. ulcer.

Gliomatosis peritonei is an extremely rare condition usually associated with either immature teratoma or, less commonly, mature teratoma. We present a case of young female long-standing progressive abdominal distension, who was diagnosed ovarian gliomatosis and gross ascites. The final diagnosis in this determined through the correlation imaging, operative, histopathological findings. presence enhancing peritoneal nodules leads to suspicion carcinomatosis or tuberculosis, especially endemic...

Background Retroareolar region refers to the within two centimeters from nipple and/or involves nipple-areolar complex on mammogram. In this study, we graded asymmetric retroareolar density mammography and determined underlying cause. Objectives To identify grade densities evaluate characteristics of lesion using ultrasonography histopathology. Methods Mammograms with done in our tertiary care hospital were included. was categorized into three grades based morphological appearance...

Background: Cell block technique is a method of preparing cytological material so that it can be processed, sectioned, stained, and viewed as histology section. The study compared two methods cell preparation, plasma-thromboplastin collodion bag preparation.
 Materials Methods: Samples were randomly processed by or technique. Hematoxylin/Eosin stained sections examined scored scaling from 1 to 3 for cellularity, clarity, nuclear features, cytoplasm, use ancillary test recovery...

Cryptococcal infection is the third most common fungal which commonly affects immune-compromised hosts but increasingly recognized in immunocompetent also. Here, we report disseminated cryptococcosis an apparently child presenting with high-grade fever, headache and altered sensorium for one month. He had pallor, lymphadenopathy, skin lesions, decreased vision, sixth seventh cranial nerve palsy, hepatosplenomegaly. Cerebrospinal fluid analysis report, contrast-enhanced Computed Tomography of...

Introduction: A solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor pancreas. Concomitant SPN with urogenital anomalies very presentation. Case Presentation: 16-year-old female presented chief complaint abdominal pain 30 days back. Solid was diagnosed aid ultrasonography and contrast-enhanced computed tomography abdomen pelvis. Incidentally, concomitant left unilateral renal agenesis bicornuate uterus were also detected in radiological findings. The patient underwent...

Tungiasis is a common parasitic infection inmany parts of the world, including South and Central America Africa. It rare in other places, such as India Pakistan imported cases have been reported Taiwan, Italy, United States America, etc. Our diagnosis was made based on histopathologiocal features parasite, which corresponds too ther reports description tungiasis.1-3 treated by surgical excision alone. The fact that disease has never Nepal makes it difficult to diagnose clinically, but should...

Spinal echinococcal cyst is very uncommon and may have variable clinical presentations. We describe an exceptional case of intradural extramedullary spinal cyst, misguided as a tumour on radiological examination was diagnosed fine needle aspiration biopsy smears subsequently histopathological examination.

When faced with eczematous lesions involving the nipple-areolar complex (NAC), Paget's disease is assumed to be diagnosis, anything else being considered a "Zebra" necessitating its exclusion on pathology. A middle-aged lady presented synchronous asymmetrical ulceration of bilateral NAC pleomorphic calcifications mammography and simultaneous extensive vascular calcification in breasts that suggested systemic cause. Calciphylaxis rare diagnosis occurring usually due underlying end-stage renal...

In this retrospective study we have correlated the clinical, ultrasonological and pathological findings of breast masses to answer whether could rely on ultrasound Fine Needle Aspiration (FNAC) for further management patients. MATERIAL AND METHODSThis is a done at Vidya Cancer Hospital, Gwalior, Madhya Pradesh, India.This has included patients from Jan. 2014 2016.The total number 50.The clinical examination by an oncology team which includes surgical oncologist, medical radiation oncologist...

Sarcina ventriculi is a gram postitive bacteria which has been reported in patients with delayed gastric emptying as well association cases of ulcer and carcinoma. Although it frequently veterinary cause fatal diseases, exact pathogenesis humans yet to be identified. We report here, case an elderly male who presented hematemesis following upper gastrointestinal endoscopy was done revealed. Histopathological examination revealed organism ulcer.