A5100682542- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Cardiovascular Health and Disease Prevention
- Asthma and respiratory diseases
- Cardiovascular Disease and Adiposity
- Enzyme Production and Characterization
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Microbial Metabolites in Food Biotechnology
- Cardiovascular and exercise physiology
- Antifungal resistance and susceptibility
- Nerve injury and regeneration
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Neurogenesis and neuroplasticity mechanisms
Seoul National University
2015-2025
Seoul National University Hospital
2014-2024
New Generation University College
2024
University Hospital Heidelberg
2024
Heidelberg University
2024
Lee University
2020
Health Insurance Review and Assessment Service
2020
Pulmonary and Critical Care Associates
2019
ORCID
2019
Seoul National University Bundang Hospital
2014-2017
Abstract Background Mycobacterium abscessus and massiliense are grouped as the complex. The aim of this study was to elucidate differences between M. lung diseases in terms progression rate, treatment outcome, predictors thereof. Methods Between 1 January 2006 30 June 2015, 56 patients 54 were diagnosed with diseases, respectively. time requiring outcomes compared 2 groups patients, sustained culture conversion analyzed. In addition, mediation analysis performed evaluate effect...
The proportion of never-smokers with non-small cell lung cancer (NSCLC) is increasing, but that in Korea has not been well addressed a large population. We aimed to evaluate the and clinical features NSCLC single institution. analyzed data 1860 consecutive patients who were newly diagnosed between June 2011 December 2014. Of patients, 707 (38.0%) never-smokers. proportions women (83.7% vs. 5.6%) adenocarcinoma (89.8% 44.9%) higher among than ever-smokers. Significantly more at younger median...
Although it has been demonstrated that visceral adipose tissue content and serum levels of adiponectin are associated with metabolic syndrome, their predictive potential for the development syndrome remains to be elucidated.We studied 1,130 participants Seoul Metabolic Syndrome cohort. A total 337 subjects without underwent follow-up evaluation finally analyzed. Visceral fat area (VFA) was measured using dual bioelectrical impedance analysis. We compared 1-year incidence rate among four...
All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim this study was to compare the between individuals with those without bronchiectasis.Patients or determined based on chest computed tomography (CT) at one centre 2005 2016 were enrolled. Among bronchiectasis, a control group selected after applying additional exclusion criteria. We compared groups lung disease. Subgroup analyses also performed according identification Pseudomonas...
A three-drug regimen (macrolide, ethambutol, and rifampicin) is recommended for the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Although macrolide has proven efficacy, role ethambutol rifampicin in patients without acquired immune deficiency syndrome not with clinical studies. We aimed to clarify roles MAC-PD.Patients treated MAC-PD between March 1st, 2009 October 31st, 2018 were reviewed retrospectively. Rates culture conversion, microbiological cure, failure,...
Abstract Purpose We aimed to investigate the associations between serum matrix metalloproteinase (MMP)-2 and MMP-9 levels obstructive sleep apnea (OSA) severity with a focus on nocturnal hypoxemia. Methods The OSA patients ( n = 105) were recruited from prospective cohort after polysomnography, 27 healthy volunteers as controls. was assessed via apnea–hypopnea index (AHI) percent night time SpO 2 < 90% (T90). Results significantly higher in (AHI ≥ 5/h, 68.8 ± 44.9 ng/mL) than controls...
Percutaneous needle aspiration or biopsy (PCNA PCNB) is an established diagnostic technique that has a high yield. However, its role in the diagnosis of nodular ground-glass opacities (nGGOs) controversial, and necessity preoperative histologic confirmation by PCNA PCNB nGGOs not been well addressed. We here evaluated rates malignancy surgery-related complications, cost benefits resecting without prior tissue when those were highly suspected for based on their size, radiologic...
Objectives: Prone position ventilation improves oxygenation and reduces the mortality of patients with severe acute respiratory distress syndrome. However, there is limited evidence about which would gain most survival benefit from prone positioning. Herein, we investigated whether improvement in after positioning associated aimed to identify who will Design: A retrospective cohort study. Setting: Medical ICU at a tertiary academic hospital between 2014 2020. Patients: Adult receiving for...
Excitotoxicity and oxidative stress mediate neuronal death after hypoxic—ischemic brain injury. We examined the possibility that targeting both N-methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity would result in enhanced neuroprotection against hypoxic—ischemia. 2-Hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid (Neu2000) was derived from aspirin sulfasalazine to prevent NMDA neurotoxicity stress. In cortical cell cultures, Neu2000 shown be an uncompetitive...
Although arterial stiffness has been associated with the development of atherosclerosis, role brachial-ankle pulse wave velocity (baPWV) for diagnosing composite coronary and carotid atherosclerosis not completely elucidated.We enrolled 773 asymptomatic individuals who were referred from 25 public health centers in Seoul underwent ultrasonography computed tomography. Non-invasive hemodynamic parameters, including baPWV, also measured. Composite was defined as follows: 1) artery calcium (CAC)...
<b><i>Introduction:</i></b> In the general population, short and long sleep durations have been associated with adverse health outcomes. However, this association remains unclear in patients chronic kidney disease (CKD). We examined relationship of duration to mortality health-related quality life (HRQOL) individuals CKD. <b><i>Methods:</i></b> A total 1,783 adults CKD who participated 2007–2015 Korea National Health Nutrition Examination...
Abstract Current knowledge regarding the relationship between obstructive sleep apnea (OSA) and risk of lung cancer is limited. This study aimed to evaluate associations OSA incidence based on Korean National Health Information Database. The outcome was newly diagnosed cancer, a Cox proportional hazards model used for analysis. A total 181,070 adult patients with 2011 2018 were matched those without by up 1:5 propensity score matching age sex. During follow-up over (mean ± standard...
We investigated whether an intensive individualized reinforcement education program could influence the prevention of hypoglycemic events in patients with type 2 diabetes. From March 2013 to September 2013, aged 35 75 years diabetes who had not previously participated education, and treated insulin or a sulfonylurea-containing regimen were included study. After structured group assigned (IT) requested visit for reinforcement. All subjects IT encouraged self-manage dose adjustments....
Patients with liver cirrhosis (LC) are at risk for critical events leading to Intensive Care Unit (ICU) admission. Coagulopathy in cirrhotic patients is complex and can lead bleeding as well thrombosis. The aim of this study was investigate complications critically ill LC admitted a medical ICU (MICU).All adult our MICU diagnosis from January 2006 December 2012 were retrospectively assessed. major the time admission excluded analysis.A total 205 included analysis. median patient age 62...
Abstract Heat shock proteins (HSPs) are immediately expressed in neuronal and glial cells under various stressful conditions play a protective role through molecular chaperones. Although several studies have been focused on the expression of HSPs, little is known about HSP90s neuropathological conditions. In this study, we evaluated pattern cell‐related HSP90 GRP94 proteins, following induction an excitotoxic lesion mouse brain. Adult mice received intracerebroventricular injection kainic...
Risk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although is similar composition to tobacco smoke. To investigate whether the risk COPD differs from that smoke, we recruited patients two Korean multicenter prospective cohorts. In a multiple linear regression model, standardized coefficient (β) exposure ≥25 years was most (β′) ≥10 pack-years (β = − 0.13 and β′ 0.14). We grouped into four categories based on above...
Abstract The objective was to evaluate the prevalence of patients at a high risk having OSA by using screening questionnaire and investigate whether can predict who are cardiopulmonary events occurring during bronchoscopy under sedation. We prospectively enrolled consecutive adult underwent flexible bronchoscopies moderate snoring, tiredness, observed apnea, blood pressure-body mass index, age, neck circumference gender (STOP-Bang) used identify (score ≥ 3 8) or low < OSA. included...
Gliomas are the most common malignant primary brain tumors in adults and one of deadliest types cancer. There many challenges treatment monitoring due to genetic diversity high intrinsic heterogeneity appearance, shape, histology, response. Treatments include surgery, radiation, systemic therapies, with magnetic resonance imaging (MRI) playing a key role planning post-treatment longitudinal assessment. The 2024 Brain Tumor Segmentation (BraTS) challenge on glioma MRI will provide community...
To identify a screening tool for obstructive sleep apnea (OSA) and evaluate the effects of endoscopic transsphenoidal surgery on improving OSA in patients with acromegaly.