A5043028860- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Advanced Chemical Sensor Technologies
- RNA modifications and cancer
- Nanocomposite Films for Food Packaging
- Analytical chemistry methods development
- Melanoma and MAPK Pathways
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Postharvest Quality and Shelf Life Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- Natural Fiber Reinforced Composites
- biodegradable polymer synthesis and properties
- Food composition and properties
- Biochemical Analysis and Sensing Techniques
- Ginseng Biological Effects and Applications
- Chromatin Remodeling and Cancer
- interferon and immune responses
- RNA regulation and disease
- HIV Research and Treatment
Shanghai Jiao Tong University
2021-2025
Sichuan Agricultural University
2024-2025
Chengdu University of Traditional Chinese Medicine
2019-2020
Wenzhou Medical University
2018
TOX4 is one of the regulatory factors PP1 phosphatases with poorly understood functions. Here we show that chromatin occupancy pattern resembles RNA polymerase II (Pol II), and its loss increases cellular level C-terminal domain (CTD) phosphorylated Pol but mainly decreases on promoters. In addition, elongation rate analyses by 4sUDRB-seq suggest restricts pause release early promotes late elongation. Moreover, TT-seq indicate transcriptional output. Mechanistically, may restrict through...
Histone H3 is a nucleosome scaffold protein that involved in variety of intracellular processes. Aberrant modification important carcinogenesis. In contrast, free histones cells can act as stimuli to trigger cellular immune responses and cell death. this study, we linked cell-penetrating peptide HIV Tat histone fragment achieve delivery tumor cells. We found Tat-conjugated polypeptides localized nuclei lung breast cancer caused A trans-configured sequence displayed dramatically improved...
Abstract An RNA-involved phase-separation model has been proposed for transcription control. Yet, the molecular links that connect RNA binding to machinery remain missing. Here we find RNA-binding proteins (RBPs) constitute half of chromatin proteome in embryonic stem cells (ESCs), and some are colocalized with polymerase (Pol) II at promoters enhancers. Biochemical analyses representative RBPs—such as PSPC1 PTBP1—show paraspeckle protein not only prevents RNA-induced premature release Pol...
Abstract The Rpd3S histone deacetylase complex suppresses cryptic initiation and maintains genomic integrity by deacetylating transcribed nucleosomes subsequent to RNA Pol II passage. Recent cryo-EM structure analysis of emphasized the significance two asymmetrical Rco1/Eaf3 dimers in nucleosome binding. However, mechanism which interacts with nucleosomal substrates while traveling elongating remains elusive. In this study, we elucidate crucial role Rco1 N-terminal Intrinsically Disordered...