A5088065047- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Heart Rate Variability and Autonomic Control
- Genetic Syndromes and Imprinting
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Ecosystem dynamics and resilience
- Circadian rhythm and melatonin
- Treatment of Major Depression
- Genetics and Neurodevelopmental Disorders
- Electrolyte and hormonal disorders
- Alcoholism and Thiamine Deficiency
- Adolescent and Pediatric Healthcare
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychological and Temporal Perspectives Research
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Neurological disorders and treatments
University of Bergen
2017-2025
Haukeland University Hospital
2021-2024
Abstract Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there presently no way to predict response guide treatment. The aim this study identify functional genes and pathways that distinguish BD Li responders (LR) from non-responders (NR). An initial Pharmacogenomics Bipolar Disorder (PGBD) GWAS lithium did not provide any significant results. As a result, we then employed network-based integrative analysis transcriptomic genomic data. In...
Mental health is vital to human well-being, and prevention strategies address mental illness have a significant impact on the burden of disease quality life. With recent developments in body-worn sensors, it now possible continuously collect data that can be used gain insights into states. This has potential optimize psychiatric assessment, thereby improving patient experiences However, access high-quality medical for research purposes limited, especially regarding diagnosed patients. To...
Abstract Background Lithium is regarded as a first‐line treatment for bipolar disorder (BD), but partial response and non‐response commonly occurs. There exists need to identify lithium non‐responders prior initiating treatment. The Pharmacogenomics of Bipolar Disorder (PGBD) Study was designed predictors response. Methods PGBD an eleven site prospective trial in I disorder. Subjects were stabilized on monotherapy over 4 months gradually discontinued from all other psychotropic medications....
Manic episodes of bipolar disorder can lead to uncritical behavior and delusional psychosis, often with destructive consequences for those affected their surroundings. Early detection intervention a manic episode are crucial prevent escalation, hospital admission, premature death. However, people may not recognize that they experiencing symptoms, such as euphoria increased productivity also deter individuals from seeking help. This work proposes perform user-independent, automatic mood-state...
Bipolar disorder (BD) is a chronic recurrent mood associated with autonomic nervous system (ANS) dysfunction, indexed by heart rate variability (HRV). Changes in HRV between states are sparsely studied longitudinally. We aimed to compare of hospitalized manic individuals their own euthymic selves naturalistic observational study.34 were included, which 16 lost follow-up. Ultimately 15 patients provided reliable data both and state, using photoplethysmography (PPG) sensor wristbands...
Abstract Introduction Alterations in motor activity are well‐established symptoms of bipolar disorder, and time series can be considered complex dynamical systems. In such systems, early warning signals (EWS) occur a critical transition period preceding sudden shift (tipping point) the system. EWS statistical observations occurring due to system's declining ability maintain homeostasis when approaching tipping point. The aim was identify periods mood state changes. Methods Participants with...
Changes in motor activity are core symptoms of mood episodes bipolar disorder. The manic state is characterized by increased variance, augmented complexity and irregular circadian rhythmicity when compared to healthy controls. No previous studies have mania euthymia intra-individually activity. aim this study was characterize differences comparing patients their euthymic selves. Motor collected from 16 inpatients remission. 24-h recordings 2-h time series the morning evening were analyzed...
Abstract Background Bipolar disorder (BD) is characterized by episodes of depression and mania disrupted circadian rhythms. Lithium an effective therapy for BD, but only 30%–40% patients are fully responsive. Preclinical models show that lithium alters However, it unknown if the rhythm effects essential to its therapeutic properties. Methods In secondary analyses a multi‐center, prospective, trial we examined relationship between rhythms response lithium. Using standardized instruments,...
Abstract Bipolar disorder (BD) is characterized by alterations in mood, energy levels and the ability to function. Accordingly, it also associated with dysfunction of autonomic nervous system (ANS), indexed heart rate variability (HRV). Literature concerning differences ANS functioning between mood states still sparse. The main aim study was investigate within-individual changes HRV from manic euthymic bipolar (BD). This first do so using wrist-worn sensors. Seventeen patients BD were...
Abstract Background Alterations in motor activity are well-established symptoms of bipolar disorder, and time series can be considered complex dynamical systems. In such systems, early warning signals (EWS) occur a critical transition period preceding sudden shift (tipping point) the system. EWS statistical observations occurring due to system’s declining ability maintain homeostasis when approaching tipping point. The aim was identify periods mood state changes. Methods Participants with...
Machine learning research within healthcare frequently lacks the public data needed to be fully reproducible and comparable. Datasets are often restricted due privacy concerns legal requirements that come with patient-related data. Consequentially, many algorithms models get published on same topic without a standard benchmark measure against. Therefore, this paper presents HYPERAKTIV, dataset containing health, activity, heart rate from patients diagnosed attention deficit hyperactivity...
The lifetime prevalence of suicide is around 5% in patients with schizophrenia. Non-adherence to antipsychotic medication an important risk factor, but prospective studies investigating joint effects drugs, antidepressants, and benzodiazepines on suicidality are scarce. We aimed investigate how use non-use psychotropic medications associated
ABSTRACT Aims Changes in motor activity are core symptoms of mood episodes bipolar disorder. The manic state is characterized by increased variance, augmented complexity and irregular circadian rhythmicity when compared to healthy controls. aim was characterize differences comparing patients their euthymic selves. Methods Motor collected from 14 inpatients mania remission. 24-h recordings 2-h time series the morning evening were analyzed for mean activity, variability complexity. Lastly,...
Abstract Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there presently no way to predict response guide treatment. The aim this study identify functional genes and pathways that distinguish BD Li responders (LR) from non-responders (NR). An initial Pharmacogenomics Bipolar Disorder (PGBD) GWAS lithium did not provide any significant results. As a result, we then employed network-based integrative analysis transcriptomic genomic data. In...