A5053476878- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Mental Health Research Topics
- Migraine and Headache Studies
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Transcranial Magnetic Stimulation Studies
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Circadian rhythm and melatonin
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Psychological and Temporal Perspectives Research
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience of respiration and sleep
- Suicide and Self-Harm Studies
- Mental Health Treatment and Access
- Neurological disorders and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Adolescent and Pediatric Healthcare
- Heart Rate Variability and Autonomic Control
- Sympathectomy and Hyperhidrosis Treatments
Haukeland University Hospital
2016-2025
University of Bergen
2016-2025
Oslo University Hospital
2015-2024
Novartis (Norway)
2022-2024
Dalhousie University
2022
University of Iowa
2022
University of California, San Diego
2009-2022
University of Michigan
2022
Salk Institute for Biological Studies
2022
California University of Pennsylvania
2022
Personal and ubiquitous sensing technologies such as smartphones have allowed the continuous collection of data in an unobtrusive manner. Machine learning methods been applied to sensor predict user contextual information location, mood, physical activity, etc. Recently, there has a growing interest leveraging for mental health care applications, thus, allowing automatic monitoring different conditions depression, anxiety, stress, so on. This paper surveys recent research works systems...
Depression is associated with impairment of cognitive functions, and especially executive functions (EFs). Despite the fact that most depressed patients experience recurrence episodes, pattern severity have not been well characterized in this group patients. We asked if to what extent these were impaired on a range neuropsychological tests measuring EFs, also when confounding factors adjusted for. Forty-five (aged 19–51 years) moderate severe (Hamilton score >18) recurrent major depressive...
Objective: Electroconvulsive therapy (ECT) is regarded by many clinicians as the most effective treatment for treatment-resistant bipolar depression, but no randomized controlled trials have been conducted, to authors’ knowledge. They compared efficacy measures of ECT and algorithm-based pharmacological in depression. Method: This multicenter, trial was carried out at seven acute-care psychiatric inpatient clinics throughout Norway included 73 disorder patients with The were randomly...
Disturbances in motor activity pattern are seen both schizophrenia and depression. However, this has rarely been studied objectively. The purpose of the present study to complexity patterns these patients by using actigraphy. Motor was recorded wrist-worn actigraphs for periods 2 weeks with major depression compare them healthy controls. Average three non-parametric variables, interdaily stability (IS), intradaily variability (IV), relative amplitude (RA) were calculated on basis data....
BackgroundElectroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern whole-brain structural alterations following ECT remains unresolved. Here, we examined longitudinal effects on global and local variations in gray matter, white ventricle volumes patients major depressive disorder as well predictors ECT-related clinical response.MethodsLongitudinal magnetic resonance imaging data from Global ECT-MRI Research Collaboration...
Wearable sensors measuring different parts of people's activity are a common technology nowadays. In research, data collected using these devices also draws attention. Nevertheless, datasets containing sensor in the field medicine rare. Often, is non-public and only results published. This makes it hard for other researchers to reproduce compare or even collaborate. this paper we present unique dataset from patients suffering depression. The contains motor recordings 23 unipolar bipolar...
The purpose of this study has been to describe motor activity data obtained by using wrist-worn actigraphs in patients with schizophrenia and major depression the use linear non-linear methods analysis. Different time frames were investigated, i.e., counts measured every minute for up five hours made hourly two weeks. results show that was lower schizophrenic depression, compared controls. Using one intervals depressed had a higher standard deviation (SD) both ratio between root mean square...
Major depression, currently the world's primary cause of disability, leads to profound personal suffering and increased risk suicide. Unfortunately, success antidepressant treatment varies amongst individuals can take weeks months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for most severely depressed when standard treatments fail, produces a more rapid response remains effective intervention severe depression. Exploring neurobiological effects ECT is thus an...
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur tandem global seizure activity (generalized). We used field (EF) modeling 151 ECT treated depression to determine the regional relationships between EF, unbiased volume change, and antidepressant response across 85 brain regions. The majority volumes increased significantly, volumetric changes correlated (t = 3.77, df 83, r 0.38,...
Bipolar disorder is a serious and common psychiatric characterized by manic depressive mood switches relapsing remitting course. The cornerstone of clinical management stabilization prophylaxis using mood-stabilizing medications to reduce both symptoms. Lithium remains the gold standard treatment with strongest data for efficacy suicide prevention. However, many patients do not respond this medication, clinically there great need tools aid clinician in selecting correct treatment. Large...
Current practice of assessing mood episodes in affective disorders largely depends on subjective observations combined with semi-structured clinical rating scales. Motor activity is an objective observation the inner physiological state expressed behavior patterns. Alterations motor are essential features bipolar and unipolar depression. The aim was to investigate if measures can aid existing diagnostic practice, by applying machine-learning techniques analyze patterns depressed patients...
Abstract Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there presently no way to predict response guide treatment. The aim this study identify functional genes and pathways that distinguish BD Li responders (LR) from non-responders (NR). An initial Pharmacogenomics Bipolar Disorder (PGBD) GWAS lithium did not provide any significant results. As a result, we then employed network-based integrative analysis transcriptomic genomic data. In...
Article AbstractObjective: To compare the effects of right unilateral (RUL) electroconvulsive therapy (ECT) and algorithm-based pharmacologic treatment (APT) on neurocognitive function in treatment-resistant bipolar disorder depression.Method: Inpatients with DSM-IV-TR-diagnosed, depression, who were acutely admitted to 1 7 clinical study centers Norway, recruited from May 2008 April 2011 into a prospective, randomized controlled, 6-week acute trial. General was assessed MATRICS Consensus...
Mental health is vital to human well-being, and prevention strategies address mental illness have a significant impact on the burden of disease quality life. With recent developments in body-worn sensors, it now possible continuously collect data that can be used gain insights into states. This has potential optimize psychiatric assessment, thereby improving patient experiences However, access high-quality medical for research purposes limited, especially regarding diagnosed patients. To...
Bipolar disorder (BD) is characterized by disrupted circadian rhythms and neuronal loss. Lithium amplifies neuroprotective, indicating mechanistic overlap across cellular systems. We examined the role of neuroprotection in determining lithium response how clock genes regulate apoptosis. In stem‐cell‐derived progenitor cells (NPCs) from BD patients, immortalized mouse hippocampal neurons, was neuroprotective against staurosporine (STS)‐induced However, did not distinguish lithium‐responders...
Hammar, Å., Sørensen, L., Årdal, G., Oedegaard, K.J., Kroken, R., Roness, A. & Lund, (2009). Enduring cognitive dysfunction in unipolar major depression: A test–retest study using the Stroop-paradigm. Scandinavian Journal of Psychology. The aim was to investigate automatic and effortful information processing with Stroop paradigm a long term perspective patients depressive disorder (MDD). Patients were tested at two test occasions: inclusion Hamilton Depression Rating Scale (HDRS) score >18,...
Attention deficit hyperactivity disorder (ADHD) is increasingly recognized as a common not only in children, but also the adult population. Similarly, asthma has substantial prevalence among adults. Previous studies concerning potential relationship between ADHD and have presented consistent results. A cross-sectional study of 594 patients diagnosed with ADHD, compared 719 persons from general Information was collected 1997 2005 using auto-questionnaires rating past present symptoms...