A5049293416- Cancer Cells and Metastasis
- Eicosanoids and Hypertension Pharmacology
- Histone Deacetylase Inhibitors Research
- Diabetes Management and Research
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Blood properties and coagulation
- SARS-CoV-2 and COVID-19 Research
- Electrospun Nanofibers in Biomedical Applications
- Renin-Angiotensin System Studies
- Cancer Mechanisms and Therapy
- Computational Drug Discovery Methods
- Protein Degradation and Inhibitors
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Medical Imaging and Pathology Studies
- Lipoproteins and Cardiovascular Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
- Pulmonary Hypertension Research and Treatments
Biruni University
2025
Yeditepe University
2018-2024
Kocaeli Üniversitesi
2018
Istanbul Medipol University
2014
Gazi University
1998
Regulation of protein production in response to physiological signals is achieved through precise control Eukaryotic Elongation Factor 2 (eEF2), whose distinct translocase function crucial for cell survival. Phosphorylation eEF2 at its Thr56 (T56) residue inactivates this translation. Using genetically modified paralogue a colon cancer line, HCT116 which carries point mutation Ser595-to-Alanine the gene we were able create constitutively active form eEF2. Then, compared these cells with...
<b><i>Background/Aims: </i></b>The aim of the present study was to investigate effect combination aliskiren with paricalcitol on experimental diabetic nephropathy (DN) model in rats. <b><i>Methods: </i></b>Forty male Sprague Dawley rats were divided into 5 groups 8 each, namely control (Group C), diabetes D), A), P), and plus A+P) groups. Aliskiren given by oral-gavage at a dose 50 mg/kg/day once daily for 12 weeks. Paricalcitol...
The scale of the COVID-19 pandemic forced urgent measures for development new therapeutics. One these strategies is use convalescent plasma (CP) as a conventional source passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present structural, biochemical, and biological characterization our proprietary product, human immune plasma-derived exosome (ChipEXO), following guidelines set forth by Turkish Ministry Health Red Crescent, Good Manufacturing...
Type 1 diabetes is clinically characterized as the loss of control glucose homeostasis due to reduced number insulinproducing cells. Long-term glycemic after implantation could be maintained by preserving cell viability and tissue-specific functions during process microencapsulation. In this study, alginate solution was supplemented with platelet-rich plasma (PRP) improve preserve encapsulation a beta line (BRIN-BD11). Cell assessed insulin secretion stimulation index were evaluated. The...
ABSTRACT Introduction CD90 (THY1) is a GPI-anchored glycoprotein expressed mainly in neurons, T cells, endothelial fibroblasts, and some cancer cells involving cell-cell cell-matrix interactions. It also considered as marker for stem (CSCs) possessing important roles oncogenesis, multiple drug resistance, metastasis. suggests that leads to different functions tumours. Material methods In this study, we used CRISPR-Cas9 method order knockout protein expression three cell lines, A549, HGC27,...