A5082621122- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Neonatal Health and Biochemistry
- Erythrocyte Function and Pathophysiology
- Viral gastroenteritis research and epidemiology
- Transgenic Plants and Applications
- Biomedical Research and Pathophysiology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ion Transport and Channel Regulation
- COVID-19 Clinical Research Studies
- Escherichia coli research studies
- Genetic and Kidney Cyst Diseases
- Immunodeficiency and Autoimmune Disorders
- Blood groups and transfusion
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antibiotic Resistance in Bacteria
- Mechanical Circulatory Support Devices
- Potassium and Related Disorders
- Renal and related cancers
- Systemic Lupus Erythematosus Research
- Genetic Syndromes and Imprinting
- Lysosomal Storage Disorders Research
- Toxin Mechanisms and Immunotoxins
- Epilepsy research and treatment
Erciyes University
2021-2025
Research & Development Institute
2025
Van Yüzüncü Yıl Üniversitesi
2023
Children's Hospital of Philadelphia
1998-2013
University of Pennsylvania
1995-2006
Philadelphia University
1999
McGill University
1974-1989
Montreal Children's Hospital
1974-1989
Johns Hopkins Hospital
1975
Wenner-Gren Foundations
1956
Summary. The permeability of the human placenta to glucose, fructose, and d(+)xylose was studied in situ connection with legal abortions. mother given an intravenous injection sugar at constant speed. Blood samples were taken during from umbilical vein as exposed through vaginal hysterotomy simultaneously mother. In other experiments, solutions injected into vein, blood repeatedly after injection. results are expressed “apparent net transfer rates” (ANTR), i. e. change or xylose level per...
The rapid spread of SARS-CoV-2 with its mutating strains has posed a global threat to safety during this COVID-19 pandemic. Thus far, there are 123 candidate vaccines in human clinical trials and more than 190 candidates preclinical development worldwide as per the WHO on 1 October 2021. various types that currently approved for emergency use include viral vectors (e.g., adenovirus, University Oxford/AstraZeneca, Gamaleya Sputnik V, Johnson & Johnson), mRNA (Moderna Pfizer-BioNTech), whole...
Background/Objectives: The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the emergence variants with enhanced transmissibility and immune evasion, challenging existing vaccines. This study aimed evaluate immunogenicity protective efficacy inactivated bivalent vaccine formulations incorporating ancestral SARS-CoV-2 strain (ERAGEM) either Delta or Omicron (BA.5) variants. Methods: Bivalent were prepared using beta-propiolactone-inactivated antigens...
The COVID-19 pandemic has put global public health at high risk, rapidly spreading around the world. Although several vaccines are available for mass immunization, world still urgently needs highly effective, reliable, cost-effective, and safe SARS-CoV-2 coronavirus vaccines, as well antiviral therapeutic drugs, to control given emerging variant strains of virus. Recently, we successfully produced receptor-binding domain (RBD) variants in Nicotiana benthamiana plant promising vaccine...
Development of safe and effective vaccine options is crucial to the success fight against COVID-19 pandemic. Herein, we report interim safety immunogenicity findings phase 1&2 trials ERUCoV-VAC, an inactivated whole virion SARS-CoV-2 vaccine.Double-blind, randomised, single centre, 1 2 included seronegative healthy adults aged 18-55 years (18-64 in 2). All participants, except first 4 who received ERUCoV-VAC 3 μg or 6 unblinded monitored for 7 days purposes, were assigned receive two...
Continuous hemofiltration (CH) is being used in increasing numbers of pediatric intensive care unit patients. Experience with 114 CH treatments 98 critically ill children from March 1988 to 1993 presented this study. Ages ranged 1 day 23 yr (mean +/- SE = 7.1 0.7 yr), and 54% patients were male. Seventeen percent all performed neonates under month age. The most common primary diagnoses sepsis adult respiratory distress syndrome (11 each), liver transplantation hypoplastic left heart (10...
The role of specific serum and milk anti-Giardia muris antibodies in mediation host-effector responses to this enteric pathogen is unknown. We have investigated antibody-dependent cell-parasite interactions, potentially important as mediators protection against infection at the mucosal surface. Elicited mouse peritoneal neutrophils macrophages were incubated with G. trophozoites presence either or antibodies, their adherence phagocytosis parasites assessed. percentage adherent increased...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel and highly pathogenic that caused an outbreak in Wuhan City, China, 2019 then spread rapidly throughout the world. Although several disease (COVID-19) vaccines are currently available for mass immunization, they less effective against emerging SARS-CoV-2 variants, especially Omicron (B.1.1.529). Recently, we successfully produced receptor-binding domain (RBD) variants of spike (S) protein antigen cocktail Nicotiana...
The scale of the COVID-19 pandemic forced urgent measures for development new therapeutics. One these strategies is use convalescent plasma (CP) as a conventional source passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present structural, biochemical, and biological characterization our proprietary product, human immune plasma-derived exosome (ChipEXO), following guidelines set forth by Turkish Ministry Health Red Crescent, Good Manufacturing...
Vaccine-induced immunity wanes over time and warrants booster doses. We investigated the long-term (32 weeks) immunogenicity safety of a third, homologous, open-label dose TURKOVAC, administered 12 weeks after completion primary series in randomized, controlled, double-blind, phase 2 study. Forty-two participants included analysis were evaluated for neutralizing antibodies (NAbs) (with microneutralization (MNT50) focus reduction (FRNT50) tests), SARS-CoV-2 S1 RBD (Spike Receptor Binding...
SARS-CoV-2, the virus responsible for COVID-19 pandemic, belongs to betacoronavirus genus. This has a high mutation rate, which rapidly evolves into new variants with different properties, such as increased transmissibility or immune evasion. Currently, most prevalent global SARS-CoV-2 variant is Omicron, more transmissible than previous variants. Current available vaccines may be less effective against some currently existing variants, including Omicron variant. The S1 subunit of spike...