A5070533803- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Biosimilars and Bioanalytical Methods
- SARS-CoV-2 detection and testing
- Electrolyte and hormonal disorders
- Pharmaceutical studies and practices
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vaccine Coverage and Hesitancy
- Neuroendocrine regulation and behavior
- Platelet Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Complementary and Alternative Medicine Studies
- Blood Coagulation and Thrombosis Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Piperaceae Chemical and Biological Studies
- Chemical synthesis and alkaloids
- Bacterial Infections and Vaccines
- Nutrition, Genetics, and Disease
- Maternal Mental Health During Pregnancy and Postpartum
- Liver physiology and pathology
- Atrial Fibrillation Management and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Preterm Birth and Chorioamnionitis
- Treatment of Major Depression
Erciyes University
2003-2024
Development of safe and effective vaccine options is crucial to the success fight against COVID-19 pandemic. Herein, we report interim safety immunogenicity findings phase 1&2 trials ERUCoV-VAC, an inactivated whole virion SARS-CoV-2 vaccine.Double-blind, randomised, single centre, 1 2 included seronegative healthy adults aged 18-55 years (18-64 in 2). All participants, except first 4 who received ERUCoV-VAC 3 μg or 6 unblinded monitored for 7 days purposes, were assigned receive two...
We present the interim results of efficacy, immunogenicity, and safety two-dose schedules TURKOVAC versus CoronaVac. This was a randomized, observer-blinded, non-inferiority trial (NCT04942405). Volunteers were 18-55 years old randomized at 1:1 ratio to receive either or CoronaVac Day 0 28, both which are 3 μg/0.5 mL inactivated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) adsorbed aluminum hydroxide. The primary efficacy outcome prevention polymerase chain reaction...
This bioequivalence research aims to evaluate the relative bioavailability and pharmacokinetic characteristics of ethinyl estradiol drospirenone in test preparation comparison reference during fasting conditions. A liquid chromatography method with tandem mass spectrometry was used determine concentrations plasma. The parameters that were analyzed maximum plasma concentration (C
Protective neutralizing antibody titers reduce in time after COVID-19 vaccinations, as individuals who have had COVID-19. This study aimed to evaluate the safety and immunogenicity of CoronaVac TURKOVAC vaccines used a booster dose primary vaccination. double-blind, randomized, controlled, phase II, multicenter included healthy male female adults (18–60 years) were vaccinated with two doses vaccine did not exceed duration at least 90 days maximum 270 from second Among 236 eligible...
Vaccine-induced immunity wanes over time and warrants booster doses. We investigated the long-term (32 weeks) immunogenicity safety of a third, homologous, open-label dose TURKOVAC, administered 12 weeks after completion primary series in randomized, controlled, double-blind, phase 2 study. Forty-two participants included analysis were evaluated for neutralizing antibodies (NAbs) (with microneutralization (MNT50) focus reduction (FRNT50) tests), SARS-CoV-2 S1 RBD (Spike Receptor Binding...
Psoriasis is a common skin disorder associated with physical and psychological burdens. Visible disfiguration can trigger negative reaction which cause much of the readily measurable burden disease. Although many biological treatments provide some success in initial clearance lesions, there dispute about long-term maintenance disease, as no current treatment has been shown to be curative. Topical therapies are still most widely used agents first-line for psoriasis. The present study aimed...
Abstract The bioequivalence (BE) of orally administered capsules versus film tablets containing 20 and 10 mg rivaroxaban was assessed in 2 single‐dose, open‐label, randomized 2‐way crossover trials with a washout period at least 1 week. study for the strength conducted under fasting conditions (n = 68) fed 52). Blood samples were collected over 36‐hour concentrations assayed using liquid chromatography tandem mass spectrometry method. Pharmacokinetic (PK) evaluation performed program Phoenix...
<title>Abstract</title> This study aims to determine the bioequivalence of reference preparation and test containing eltrombopag when both were given during COVID-19 pandemic while fasting. Participants in research healthy male Caucasian subjects. One film-coated tablet or one film preparation, equivalent 75 mg eltrombopag, was participants a randomized order throughout each treatment session. At pre determined blood sampling points, samples taken pharmacokinetics eltrombopag. Eltrombopag...
This study aims to determine the bioequivalence of reference preparation and test containing eltrombopag when both were given during COVID-19 pandemic while fasting. Participants in research healthy male Caucasian subjects. One film-coated tablet or one film preparation, equivalent 75 mg eltrombopag, was participants a randomized order throughout each treatment session. At pre determined blood sampling points, samples taken pharmacokinetics eltrombopag. Eltrombopag concentrations using an...
The immunogenicity of vaccines decreases over time, causing a need for booster doses. This study aimed to present the long-term (Day 84) results double-blind, randomized, controlled, phase II Hybrid COV-RAPEL TR Study (NCT04979949), in which TURKOVAC or CoronaVac were used as after second dose primary vaccination with CoronaVac. A total 190 participants from Study, who had both Day 28 and 84 results, included. on 84, regarding neutralizing antibody positivity (Wuhan Delta variants)...
Background: Safe and effective vaccine options is crucial to fight against COVID-19 pandemic. We report interim safety immunogenicity findings of the phase 1&2 trials ERUCoV-VAC, an inactivated whole virion SARS-CoV-2 vaccine. Methods: Double-blind, randomised, single centre, included seronegative healthy adults aged 18-55 years (18-64 in 2). Participants, were assigned receive two intramuscular doses ERUCoV-VAC 3µg or 6µg placebo 21 days apart (28 2) via computer-generated randomisation....
Recent studies have found out that oxidative stress plays an important role in the pathophysiology of neurological diseases including depression. In this study, we aimed to investigate whether propolis which is known as strong antioxidant has antidepressant effect during experimental model depression will be developed mice.