A5064597818- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Healthcare and Venom Research
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Venomous Animal Envenomation and Studies
- Colorectal Cancer Treatments and Studies
- Cell Adhesion Molecules Research
- Digital Radiography and Breast Imaging
- IgG4-Related and Inflammatory Diseases
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Cerebrospinal fluid and hydrocephalus
Iwata City Hospital
2021-2025
Shizuoka Cancer Center
2018-2023
The University of Tokyo
2017-2021
Weatherford College
2020
Shimada Municipal Hospital
2018
Kindai University
2010-2011
Komazawa University
2009
Abstract Background Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor migration, invasion, adhesion, metastasis in B16BL6 mouse melanoma line. Methods The cytotoxicity of toward cells were evaluated using viability assay. As an experimental model, intravenously injected into C57BL/6 mice. Cell migration invasion assessed Boyden...
The purpose of this study was to evaluate the safety and efficacy hepatopancreaticoduodenectomy (HPD) for patients with biliary cancer.HPD is thought be only curative treatment widespread bile duct cancer some advanced cases gallbladder cancer; however, HPD has not yet been accepted as a standard operative procedure because concerns over morbidity mortality.Fifty-two undergoing were retrospectively reviewed. patient tumor characteristics, preoperative treatments, results, survival outcomes...
Abstract Objectives E‐learning with video content was created to improve trainees’ biliary cannulation techniques; this study aimed evaluate its educational effect prospectively. Methods program conducted using videos demonstrating for 24 papillae, targeting trainees 2–6 years of experience in endoscopic retrograde cholangiopancreatography. Ten consecutive cases native papillae performed by were prospectively assessed before and after the e‐learning, respectively. The primary outcome...
Pancreatic arteriovenous malformation is a rare disease characterized by abnormal vascular connections between arteries and veins. Despite the risk of increased intraoperative blood loss due to abundant flow, surgical resection remains only curative modality for pancreatic malformation. We present case in which subtotal stomach-preserving pancreaticoduodenectomy was successfully performed following selective arterial embolization reduce loss. A 53-year-old Southeast Asian man referred our...
Measuring a visible core length during macroscopic on-site evaluation (MOSE) can be useful for accurate diagnoses an EUS-guided fine needle biopsy (EUS-FNB). We aimed to estimate cutoff lengths predictive of correct diagnosis when using 22-gauge Franseen needles biopsies from pancreatic masses.We assessed 77 consecutive patients who underwent EUS-FNB masses between March 2018 and October 2018. At least two passes were performed in all patients, irrespective the findings on MOSE. The...
Objectives Measurement of the macroscopic visible core (MVC) length during on‐site quality evaluation (MOSE) may allow estimation sample adequacy for next‐generation sequencing (NGS), and prediction correct diagnosis in endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) pancreatic masses. Methods This multicenter prospective study included consecutive patients who underwent EUS‐TA masses using a 22‐G Franseen needle. MVC pathological samples obtained from two needle passes were...
Abstract Multiple myeloma (MM) is a bone disease that affects many individuals. It was recently reported macrophage inflammatory protein (MIP)‐1α constitutively secreted by MM cells. MIP‐1α causes destruction through the formation of osteoclasts (OCs). However, molecular mechanism underlying MIP‐1α‐induced OC not well understood. In present study, we attempted to clarify whereby induces in mouse macrophage‐like cell line comprising C7 We found augmented concentration‐dependent manner;...
Abstract Background Stent–stone complex ( SSC ) formation is one of the complications endoscopic biliary stent placement. This study aimed to clarify clinical characteristics and risk factors for following plastic PS placement in patients with common bile duct CBD stones. Methods We retrospectively reviewed charts 78 stones who had undergone 107 placements as palliative treatment. Demographic, historical, stent‐related data were collected analyzed. Results At removal, formations observed 18%...
Rupture of a pseudoaneurysm (PA) has been reported as rare but serious adverse event associated with endoscopic biliary stenting. We herein report 2 cases severe bleeding from PA that developed 10-14 days after placement self-expandable metallic stent (SEMS) for malignancy. The first patient was successfully embolized endovascular coiling. However, the second had wide-spreading cholangiocarcinoma and, despite being treated once by full coiling, rupture two months starting systemic...
A 74-year-old woman with a 2-year history of pancreaticoduodenectomy for pancreatic cancer was admitted to our hospital treatment obstructive jaundice due recurrent tumor, which divided the right and left hepatic ducts (RHD LHD, respectively). Endoscopic ultrasound-guided biliary drainage (EUS-BD) planned.
Objectives: Few studies are available on high negative pressure (HNP) during endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). This study compared the diagnostic yield between HNP and normal (NNP) EUS-FNA for solid pancreatic masses.Methods: Consecutive patients with masses who underwent using a 22-G needle either or NNP both first second passes were retrospectively examined yield. Rapid on-site evaluation (ROSE) was unavailable at our center. The main outcome measures number of...
Abstract We describe a case of 47-year-old male patient with initially unresectable intrahepatic cholangiocarcinoma the right liver lobe tumor thrombi extending from bile duct to common and left ducts. Conventional chemotherapy gemcitabine cisplatin for 19 months resulted in progressive disease. Subsequently, comprehensive genome profile revealed fibroblast growth factor receptor 2 rearrangement, hence, pemigatinib administration was initiated. After 6 therapy, significant shrinking...
Abstract One-stage resections of primary colorectal cancer and liver metastases have been reported to be feasible safe. Minimally invasive approaches become more common for both hepatic surgeries. This study aimed investigate outcomes these combined surgical procedures among different approaches. We retrospectively analyzed patients diagnosed as having with synchronous who underwent 1-stage resection hepatectomy curative intent in our hospital. According the approach tumor lesions, namely...
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Pancreatobiliary maljunction (PBM) is a rare congenital malformation, often associated with adenocarcinoma. However, PBM accompanying gallbladder carcinosarcoma has rarely been reported. A 72-year-old woman was referred to our hospital, complaining of abdominal pain. Computed tomography showed polypoid mass in the gallbladder. Endoscopic retrograde cholangiopancreatography PBM, and aspirated bile demonstrated elevated levels pancreatic-type amylase (26,780 U/L) cancer cells. Extended...
Endoscopic duodenal stent placement is an alternative technique to gastrojejunostomy for gastric outlet obstruction due pancreatic cancer. We compared the efficacy of endoscopic with that treating patients cancer who are candidates intensive combination chemotherapies as first line treatment.This retrospective observational study included 100 from 18 institutions in Japan. Inclusion criteria were follows: (1) cytologically or histologically confirmed adenocarcinoma pancreas, (2) good...
Osteoclast-like giant cell-type (OCGC) anaplastic carcinoma is a rare variant of pancreatic ductal adenocarcinoma, and its imaging characteristics progression pattern have not been fully clarified. The patient was 73-year-old man who had incidentally found to head tumor. Computed tomography demonstrated 3-cm marginally enhanced mass at the head, continuing toward duodenum. Diffusion-weighted magnetic resonance showed retained diffusion capacity. Duodenoscopy revealed 1.5-cm polypoid lesion,...
A small proportion of intraductal papillary mucinous neoplasms (IPMNs) are accompanied by type 1 autoimmune pancreatitis (AIP); however their clinical courses and image characteristics have not been fully reported. 65-year-old woman was referred to our hospital for the examination a pancreatic head cyst that had shown exacerbation two years. Several images demonstrated multilocular with symmetrically thickened, enhanced, wall. Cancerization IPMN suspected, pancreatoduodenectomy performed....
Stents must be of a sufficient length to prevent their migration into the abdominal cavity after endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) [1] [2]. Although self-expandable metal stent (SEMS) with long intragastric portion can occasionally migrate esophagus, this hardly ever leads severe complications. However, we present here case mediastinitis due perforation caused by SEMS.