A5075608777- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Palliative Care and End-of-Life Issues
- Hepatocellular Carcinoma Treatment and Prognosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Mechanical Circulatory Support Devices
- Blood donation and transfusion practices
- Organ Donation and Transplantation
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Folate and B Vitamins Research
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 Clinical Research Studies
- Liver Diseases and Immunity
- Electrolyte and hormonal disorders
- Liver physiology and pathology
- Thyroid Disorders and Treatments
- Healthcare cost, quality, practices
University of Minnesota
2014-2024
Twin Cities Orthopedics
2023
University of Minnesota Medical Center
2019-2021
University of Kansas Medical Center
2019
University of Kansas
2018
University of California, San Francisco
2015
Liver transplantation (LT) is a life-saving treatment for patients with acute liver failure (ALF). Currently, there are few detailed data regarding long-term outcomes after LT ALF. We combined prospective from the Acute Failure Study Group (ALFSG) Registry those of Scientific Transplant Recipients (SRTR) to assess among consecutive ALF listed LT. Cohort analysis pretransplantation in ALFSG between January 1998 and October 2018 matched transplantation-related SRTR. Primary were 1- 3-year...
Abstract Background Prior assessments of critical care outcomes in patients with cirrhosis have shown conflicting results. We aimed to provide nationwide generalizable results decompensated cirrhosis. Methods This is a retrospective study using the National Inpatient Sample from 2016 2019. Adults who required respiratory intubation, central venous catheter placement or both (n = 12,945) principal diagnoses including: esophageal variceal hemorrhage (EVH, 24%), hepatic encephalopathy (58%),...
Cancer treatment has taken giant strides in recent years with the advent of immunotherapy, including checkpoint inhibitors. The use these medications liver transplant recipients been debated, and added effect previous hepatitis C infection on immune system this setting, is poorly understood. We present a case cholestatic after recurrent hepatocellular carcinoma nivolumab post-transplant period. Understanding pathophysiology relevant to improving management type injury expanding our knowledge...
Hepatic encephalopathy (HE) is associated with significant morbidity and mortality for those cirrhosis. Despite the known benefits of rifaximin use HE, treatment retention remains low. This study aimed to evaluate impact out-of-pocket (OOP) cost on among commercially insured patients in United States.
Objective: To identify factors that accurately predict 1-year survival for liver transplant recipients with a MELD score ≥40. Background: Although is beneficial patients the highest acuity (MELD ≥40), mortality in this group high. Predicting which are likely to survive >1 year would be medically and economically helpful. Methods: The Scientific Registry of Transplant Recipients database was reviewed adult from 2002 through 2016 ≥40 at transplant. relationships between 44 recipient donor...
Treatment modalities for hepatocellular carcinoma (HCC) vary from surgical techniques and interventional radiologic strategies to systemic therapy. For the latter, use of immune checkpoint inhibitors (ICIs) has gained popularity due successful trials showing increased survival. In patients who have undergone liver transplantation, recurrence HCC poses a significant challenge. There is indeed considerable debate on efficacy safety ICI in transplant recipients competing interests maintaining...
Spontaneous survival rates in acute liver failure (ALF) are vastly improved by transplantation (LT). However, the value of induction agents beyond steroids continues to be debated. To understand potential benefit different regimens ALF population, we compared overall recipients undergoing LT United States for ALF. Using Scientific Registry Transplant Recipients, assessed impact immunosuppression (IS) a cohort 3754 first-time with diagnosis from 2002 2018. Induction IS therapy was grouped...
ABSTRACT The diagnostic evaluation of an individual with clinical and laboratory evidence thyroid dysfunction in the setting acute liver injury is crucial. There a complex relationship between liver, so, it requires careful elucidation inciting disease process before instituting treatment plan. We discuss patient who had presented coagulopathy, encephalopathy, injury, hence adjudged to have developed drug-induced failure transferred for transplant evaluation. She was found from uncontrolled...
Asparaginase plays an integral role in chemotherapy for acute lymphoblastic leukemia (ALL). We present a 69-year old woman with refractory ALL, who developed asparaginase-induced hepatotoxicity and cholangiopathy after starting intravenous PEG-L-asparaginase-based chemotherapy. The patient was ultimately treated the combination of L-carnitine vitamin B complex, resulting normalization liver enzymes levels. This case highlights consideration PEG-L asparaginase chemotherapy-induced steatosis,...
We present a case of cirrhotomimetic hepatocellular carcinoma (HCC) diagnosed on an explant following liver transplantation (LT). The pre-LT computerized tomography (CT) scan demonstrated nodular, cirrhotic-appearing liver; there was no evidence lesions consistent with HCC. level serum alpha fetoprotein (AFP) 1 month pre LT 4 ng/dL. Following LT, the patient underwent surveillance for Eight months post he noted to have lytic osseous in his sternum and T10 vertebral body. Biopsies these...