A5044731010- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Appendicitis Diagnosis and Management
- Liver Disease and Transplantation
- Diversity and Career in Medicine
- Hemodynamic Monitoring and Therapy
- Transplantation: Methods and Outcomes
- Palliative Care and End-of-Life Issues
- Health and Medical Research Impacts
- Meta-analysis and systematic reviews
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- Intraperitoneal and Appendiceal Malignancies
- Cardiac Arrest and Resuscitation
- Polyomavirus and related diseases
- Histiocytic Disorders and Treatments
- Mechanical Circulatory Support Devices
- Maternal and fetal healthcare
- Alcoholism and Thiamine Deficiency
- Tuberous Sclerosis Complex Research
University of Pennsylvania
2021-2025
Vanderbilt University Medical Center
2025
University of Pennsylvania Health System
2024
Villanova University
2024
Penn Center for AIDS Research
2022-2024
Hospital of the University of Pennsylvania
2022-2024
California University of Pennsylvania
2022
The University of Texas Health Science Center at Houston
2022
Society of Critical Care Medicine
2021
The University of Texas Health Science Center at San Antonio
2018-2020
<h3>Importance</h3> Drug shortages in the United States are common, but their effect on patient care and outcomes has rarely been reported. <h3>Objective</h3> To assess changes to associated with a 2011 national shortage of norepinephrine, first-line vasopressor for septic shock. <h3>Design, Setting, Participants</h3> Retrospective cohort study 26 US hospitals Premier Healthcare Database baseline rate norepinephrine use at least 60% patients The included adults shock admitted between July 1,...
OBJECTIVE: To describe presenting symptoms and signs according to age group in a cohort of 243 patients with tuberous sclerosis complex (TSC) identify earlier that did not lead immediate diagnosis. PATIENTS AND METHODS: We performed retrospective chart review for 278 TSC who were examined at Children's Hospital Boston Massachusetts the Herscot Center Tuberous Sclerosis Complex, General Hospital. The symptom or sign was first cause suspicion Missed those documented patient's but immediately...
Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for treatment of neuroblastoma. However, is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K332A) limit complement-dependent cytotoxicity (CDC) would ameliorate pain behavior, while preserving antibody-dependent cellular (ADCC). In vitro, CDC and ADCC were measured using...
Background The effects of spinal versus general anesthesia on long-term outcomes have not been well studied. This study tested the hypothesis that is associated with better survival and functional recovery than anesthesia. Methods A prespecified analysis was conducted a completed randomized superiority trial compared for hip fracture repair. Participants included previously ambulatory patients 50 yr age or older at 46 U.S. Canadian hospitals. Patients were 1:1 to anesthesia, stratified by...
In the field of organ transplantation, accurate assessment donor quality is necessary to efficient allocation and informed consent for recipients. A common approach development statistical models that accurately predict post-transplant survival by integrating multiple characteristics allograft. Despite proliferation predictive across many domains medicine, physicians may have limited familiarity with how these are built, well function in their population risks a poorly performing model. Our...
Rationale: Key knowledge gaps exist in understanding what drives donor utilization decisions and contributes to the significant variability organ offer acceptance rates. Defining addressing factors that explain rates across United States (US) transplant centers is a key area of need. Objective: To identify clinical system-level influence evaluation graft by lung clinicians. Methods: We conducted semi-structured interviews with clinicians who actively participate calls make at US center...
Lele, Abhijit V. MBBS, MD, MSCR, FNCS, CPHQ; Vail, Emily A. MSc; O'Reilly-Shah, Vikas N. PhD; deGrauw, Xinyao PhD, MPH; Domino, Karen B. MD; Walters, Andrew M. Fong, Christine T. MS; Gomez, Courtney Naik, Bhiken I. MBBCh, MSCR; Mori, Makoto Schonberger, Robert MHCDS; Deshpande, Ranjit MBA, FCCM; Freundlich, E. MS, MSCI; Mathis, Michael R. Mhyre, Jill Souter, J. MBChB, DA, FRCA, FNCS Author Information
Rationale: Vasopressin may be used to treat vasodilatory hypotension in septic shock, but it is not recommended by guidelines as a first- or second-line agent. Little known about how often the drug currently shock.Objectives: We conducted this study describe patterns of vasopressin use large cohort U.S. adults with shock and identify patient hospital characteristics associated use.Methods: This was retrospective admitted hospitals Premier healthcare database (July 2008 June 2013). performed...
Rationale: In December 2016, a single-center study describing significant improvements in mortality among small group of patients with severe sepsis and septic shock treated hydrocortisone, high-dose ascorbic acid, thiamine (HAT therapy) was published online.Objectives: This aims to describe the administration HAT therapy U.S. adults before after publication compare outcomes between who received did not receive therapy.Methods: We performed retrospective cohort 379 acute care hospitals...
Section:ChooseTop of pageAbstract <<Immortal Time Bias and It...Study Reporting Elements ...Susceptibility Observa...Persistence Unaddresse...Conclusions Future Di...ReferencesCITING ARTICLES
As anaesthesiologists face increasing clinical demands and a limited competitive funding environment for academic work, the sustainability of has never been more tenuous. Yet, speciality needs in many roles, extending beyond routine duties. Anaesthesiologist educators, researchers, administrators are required not only to train future generations but also lead innovation expansion anaesthesiology related specialities, all improve patient care. This group early career researchers with...
Pulmonary hypertension (PH) is a challenging disease process to manage. Respiratory and hemodynamic changes that accompany general anesthesia lead significant risk of cardiovascular collapse. Certain cases decompensated PH require extracorporeal membrane oxygenation (ECMO) support as either bridge lung transplantation or recovery. Performing ECMO cannulation without intubation in these patients may be safer given the severity their underlying process. We present three upper body performed on...
Intraoperative events and clinical management of deceased organ donors after brain death are poorly characterized may consequently vary between hospitals procurement organization (OPO) regions. In a multicenter cohort, we sought to estimate the incidence hypotension anesthetic nonanesthetic medication use during recovery procedures.
Uncertainty remains regarding the risks associated with single-dose use of etomidate.
Recovery of donated organs at organ procurement organization (OPO)-based recovery facilities has been proposed to improve donation outcomes, but few data exist characterize differences between and acute-care hospitals.
Importance Centralizing deceased organ donor management and recovery into care units (DCUs) may mitigate the critical shortage by positively impacting donation recipient outcomes. Objective To compare lung transplant outcomes between 2 common DCU models: independent (outside of acute-care hospitals) hospital-based. Design, Setting, Participants This is a retrospective cohort study Organ Procurement Transplantation Network registry files from 21 US service areas with an operating DCU....