A5031609692- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- Histone Deacetylase Inhibitors Research
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- CAR-T cell therapy research
- Mobile Health and mHealth Applications
- Pancreatic and Hepatic Oncology Research
- Acute Lymphoblastic Leukemia research
- Biochemical and Molecular Research
- Criminal Justice and Penology
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
- Names, Identity, and Discrimination Research
- Cancer Research and Treatments
- Nutritional Studies and Diet
- Immune Response and Inflammation
- Nutrition, Genetics, and Disease
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
Madrid Institute for Advanced Studies
2021-2025
IMDEA Food
2021-2025
Universidad Autónoma de Madrid
2022-2023
Fraunhofer Institute for Microengineering and Microsystems
2020
Institute of Molecular Biology
2018
Institut d'Investigació Biomédica de Bellvitge
2017
Instituto de Salud Carlos III
2009-2015
Universitat de Barcelona
2012
Centro Nacional de Microbiologia
2012
Colorectal cancer (CRC) is characterized by major inter-tumor diversity that complicates the prediction of disease and treatment outcomes. Recent efforts help resolve this sub-classification CRC into natural molecular subtypes; however, strategy not yet able to provide clinicians with improved tools for decision making. We here present an extended framework stratification specifically aims improve patient prognostication. Using transcriptional profiles from 1,100 CRCs, including >300...
Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients primary performed using histological biomarkers such as tumor thickness ulceration. As disruption epigenomic landscape recognized a widespread feature inherent in development progression, we aimed to identify novel providing additional clinical information over current factors unbiased genome-wide DNA methylation analyses.We comprehensive analysis during all...
The increasing prevalence of diet-related diseases calls for an improvement in nutritional advice. Personalized nutrition aims to solve this problem by adapting dietary and lifestyle guidelines the unique circumstances each individual. With latest advances technology data science, researchers can now automatically collect analyze large amounts from a variety sources, including wearable smart devices. By combining these diverse data, more comprehensive insights human body its be achieved....
CD69 is a type II C-type lectin involved in lymphocyte migration and cytokine secretion. expression represents one of the earliest available indicators leukocyte activation its rapid induction occurs through transcriptional activation. In this study we examined molecular mechanism underlying mouse gene transcription vivo T B cells. Analysis 45-kb region upstream revealed evolutionary conservation at promoter four noncoding sequences (CNS) that were called CNS1, CNS2, CNS3, CNS4. These...
Previously, combined loss of different anticodon loop modifications was shown to impair the function distinct tRNAs in Saccharomyces cerevisiae. Surprisingly, each scenario resulted shared cellular phenotypes, basis which is unclear. Since tRNA modification may evoke transcriptional responses, we characterized global transcription patterns mutants with defects either tRNAGlnUUG or tRNALysUUU function. We observe that share inappropriate induction multiple starvation responses exponential...
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common cancer in children, and significant progress has been made diagnostics treatment of this disease based on subtypes BCP-ALL. However, a large proportion cases (B-other), recurrent BCP-ALL-associated genomic alterations remain unidentifiable by current diagnostic procedures. In study, we performed RNA sequencing analyzed gene fusions, expression profiles, mutations samples 185 children with Gene clustering showed that...
Abstract Food–drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of drug. FDIs can be clinically relevant, as they hamper enhance therapeutic effects drug and impact both their efficacy safety. However, knowledge in clinical practice is limited. This partially due to lack resources focused on FDIs. Here, we describe FooDrugs, database that centralizes FDI retrieved from two different approaches: natural processing language pipeline extracts...
Abstract Background The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature arising commonly from receptor αβ -positive CD8 + memory cytotoxic T cells, is only partly understood. role deregulated methylation in T-LGLL not well known. We analyzed the epigenetic profile cells 11 patients compared to their normal counterparts by array-based DNA profiling. For identification events driving T-LGLL, we differentially methylated loci between cases and with...
Characterization of gene regulatory networks is fundamental to understanding homeostatic development. This process can be simplified by analyzing relatively simple genomes such as the genome Drosophila melanogaster. In this work we have developed a computational framework in explore for presence circuits between two large groups transcriptional regulators: epigenetic group Polycomb/trithorax (PcG/trxG) proteins and microRNAs (miRNAs). We searched genome-wide miRNA targets PcG/trxG...
Event Abstract Back to CD69 expression and leukocyte distribution in CD69-BAC transgenic mice Teresa Laguna1, 2*, Laura Notario1 Pilar Lauzurica1, 2 1 Instituto de Salud Carlos III, Spain Universitat Barcelona, Expressed on almost every leukocyte, function has been related co-stimulation lymphocytes, inhibition of pro-inflammatory responses leukocytes. Here we give new clues the complex regulation its effects immune system. We observed alterations several populations' CD69-overexpressing...
Event Abstract Back to RUNX transcription factors regulate the transcriptional activity of CD69 Teresa Laguna1, 2*, Laura Notario1 and Pilar Lauzurica1, 2 1 Instituto de Salud Carlos III, Spain Universitat Barcelona, receptor is considered a universal marker leukocyte activation; however, it immediately expressed after lymphocyte activation appears on other surfaces at later times. It has been also related with expression migration controller molecule S1P1, revealing an dependent...
Food natural compounds are of interest as modulators cancer progression and prognosis, they participate in cellular processes such growth differentiation, DNA repair, programmed cell death oxidative stress. Here we select dietary biocompounds for specific subgroups 285 colorectal adenocarcinoma (COAD) samples by finding bioactives with opposite transcriptomic profiles to the subgroup-specific tumoral transcriptomes, hypothesizing may counteract gene-expression profiles. To establish a CRC...