A5064900870- Burkholderia infections and melioidosis
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Vibrio bacteria research studies
- Chemical Looping and Thermochemical Processes
- Bacterial Identification and Susceptibility Testing
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Urinary Tract Infections Management
- Brucella: diagnosis, epidemiology, treatment
- Nosocomial Infections in ICU
- Hemoglobinopathies and Related Disorders
- Vaccine Coverage and Hesitancy
- Global Maternal and Child Health
- Amoebic Infections and Treatments
- Climate Change and Health Impacts
- Machine Learning in Healthcare
- Moringa oleifera research and applications
- Patient Satisfaction in Healthcare
- Global Health and Epidemiology
- Healthcare Systems and Reforms
- Pancreatitis Pathology and Treatment
Mahidol Oxford Tropical Medicine Research Unit
2016-2025
Mahidol University
2016-2025
IQVIA (United Kingdom)
2025
London School of Hygiene & Tropical Medicine
2020
Sappasithiprasong Hospital
2020
University of Oxford
2020
Bangkok University
2017
University of Washington
2017
A recent modelling study estimated that there are 2800 deaths due to melioidosis in Thailand yearly. The Melioidosis Network (formed 2012) has been working closely with the Ministry of Public Health (MoPH) investigate and reduce burden this disease. Based on updated data, incidence is still high Northeast Thailand. More than 2000 culture-confirmed cases diagnosed general hospitals microbiology laboratories region each year. mortality rate around 35%. endemic throughout Thailand, but it not...
Abstract Background National notifiable diseases surveillance system (NNDSS) data in developing countries is usually incomplete, yet the total number of fatal cases reported commonly used for national priority setting. Melioidosis, an infectious disease caused by Burkholderia pseudomallei, largely underrecognized policy makers due to underreporting via NNDSS. Methods Collaborating with Epidemiology Division (ED), Ministry Public Health (MoPH), we conducted a retrospective study determine...
There are few studies comparing proportion, frequency, mortality and rate following antimicrobial-resistant (AMR) infections between tertiary-care hospitals (TCHs) secondary-care (SCHs) in low middle-income countries (LMICs) to inform intervention strategies. The aim of this study is demonstrate the utility an offline tool generate AMR reports data for a secondary analysis. We conducted secondary-data analysis on retrospective, multicentre hospitalised patients Thailand. Routinely collected...
Simple, bedside prediction of infection-related mortality in low-resource settings is crucial for triage and resource-utilisation decisions. We aimed to evaluate by combining point-of-care venous lactate with the quick Sequential Organ Failure Assessment (qSOFA) score adult patients admitted hospital suspected infection southeast Asia.We performed a cohort study prospectively enrolling aged 18 years or older who had been within previous 24 h (with at least three documented systemic...
Purpose: To describe the top three causative organisms of hospital acquired pneumonia (HAP) and ventilator-associated (VAP) in Thailand.Patients Methods: This multi-center retrospective cohort study included HAP/VAP patients hospitalized 2019 university-affiliated hospitals a private Bangkok, Thailand.Medical records with documented diagnosis nosocomial (NP) were systematically reviewed to collect data on demographic, clinical, microbiological, 30-day readmission due NP. Results: A total 240...
Subphenotypes of infected patients have been reported in Europe and North America, but few studies investigated populations Southeast Asia. We sought to identify differentiate subphenotypes hospitalized with suspected infection rural Thailand using biological markers implicated the dysregulated host response. In a cohort prospectively enrolled northeastern Thailand, we measured 15 circulating biomarkers from random selection 585 subjects developed latent profile models subphenotypes. Patient...
ABSTRACT Burkholderia pseudomallei is a soil-dwelling bacterium and the cause of melioidosis, which kills an estimated 89,000 people per year worldwide. Agricultural workers are at high risk infection due to repeated exposure bacterium. Little known about soil physicochemical properties associated with presence or absence organism. Here, we evaluated B. in 6,100 samples collected from 61 rice fields Thailand. The was negatively proportion clay, moisture, level salinity, percentage organic...
Infection and sepsis are leading causes of death worldwide but the epidemiology outcomes not well understood in resource-limited settings. We conducted a four-year prospective observational study from March 2013 to February 2017 examine clinical adults admitted with community-acquired infection tertiary-care hospital Ubon Ratchathani province, Northeast Thailand. Hospitalized patients accompanying systemic manifestations within 24 hours admission were enrolled. Subjects classified as having...
Abstract Background Few studies of biomarkers as predictors outcome in infection have been performed tropical, low- and middle-income countries where the burden sepsis is highest. We evaluated whether selected could predict 28-day mortality infected patients rural Thailand. Methods Four thousand nine hundred eighty-nine adult admitted with suspected to a referral hospital northeast Thailand were prospectively enrolled within 24 h admission. In secondary analysis 760 patients, interleukin-8...
ABSTRACT Burkholderia pseudomallei and cepacia are Gram-negative, soil-dwelling bacteria that found in a wide variety of environmental niches. While B. is the causative agent melioidosis humans animals, members complex typically only cause disease immunocompromised hosts. In this study, we report identification strains isolated from either patients or soil Laos Thailand express -like 6-deoxyheptan capsular polysaccharide (CPS). These were initially identified based on their positive...
Dengue is a common cause of infection in adults tropical countries. Sepsis syndrome systemic manifestations induced by any organisms; including bacterial, fungal and viral agents. Here, we investigated the diagnosis, management outcomes dengue patients presenting with sepsis prospective study community-acquired Thailand.From June to December 2015, 874 adult (age≥18 years) suspected or documented infection, ≥3 diagnostic criteria for according Surviving Campaign 2012, within 24 hours...
ObjectivesThe magnitude of impact caused by low blood culture utilization on estimates the proportions and incidence rates antimicrobial-resistant (AMR) bacterial infections is largely unknown.MethodsWe used routine electronic databases microbiology, hospital admission drug prescription at Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand, from 2011 to 2015, bootstrap simulations.ResultsThe Escherichia coli Klebsiella pneumoniae bacteraemias 3rd generation cephalosporin resistant...
Background Burkholderia pseudomallei is an environmental Gram-negative bacillus and the cause of melioidosis. B. thailandensis, some strains which express a pseudomallei-like capsular polysaccharide (BTCV), also commonly found in environment Southeast Asia but considered non-pathogenic. The aim study was to determine distribution thailandensis its variant Thailand investigate whether presence associated with serological response pseudomallei. Methodology/principal findings We evaluated 61...
Sepsis can be caused by malaria infection, but little is known about the utility of quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) and SOFA score in malaria. We conducted a prospective observational study from March 2013 to February 2017 examine adults admitted with community-acquired infection tertiary-care hospital Ubon Ratchathani, Northeast Thailand (Ubon-sepsis). Subjects were classified as having sepsis if they had modified ≥2 within 24 hours admission. Serum was...
Background Reporting cumulative antimicrobial susceptibility testing data on a regular basis is crucial to inform resistance (AMR) action plans at local, national, and global levels. However, analyzing generating report are time consuming often require trained personnel. Objective This study aimed develop test an application that can support local hospital analyze routinely collected electronic independently generate AMR surveillance reports rapidly. Methods An offline standardized from...
Information on notifiable bacterial diseases (NBD) in low- and middle-income countries (LMICs) is frequently incomplete. We developed the AutoMated tool for Antimicrobial resistance Surveillance System plus (AMASSplus), which can support hospitals to analyze their microbiology hospital data files automatically (in CSV or Excel format) promptly generate antimicrobial surveillance NBD reports PDF formats). The included total number of cases deaths after Brucella spp., Burkholderia...
Abstract Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across regions. The causative agent Burkholderia pseudomallei, gram-negative soil-dwelling bacterium. In Thailand, B. pseudomallei can be found multiple regions, along the low-virulence thailandensis and recently discovered variant (BTCV), which expresses pseudomallei–like capsular polysaccharide. Comprehensive studies human immune responses to variants cross-reactivity are...
Background Melioidosis, an infectious disease caused by Burkholderia pseudomallei , is endemic in many tropical developing countries and has a high mortality. Here we evaluated combinations of lateral flow immunoassay (LFI) detecting B . capsular polysaccharide (CPS) enzyme-linked immunosorbent assays (ELISA) antibodies against hemolysin co-regulated protein (Hcp1) or O-polysaccharide (OPS) for diagnosing melioidosis. Methodology/Principal findings We conducted cohort-based case-control...
Culture is the gold standard for diagnosis of melioidosis, an infection caused by Burkholderia pseudomallei. Here we evaluate a lateral flow immunoassay (LFI) to detect B. pseudomallei capsular polysaccharide (CPS) in serum samples.Patients with culture from any clinical specimen positive were selected as cases. Patients who blood Staphylococcus aureus, Escherichia coli or Klebsiella pneumoniae well those malaria dengue polymerase chain reaction assay controls.The sensitivity LFI was 31.3%...
The burden of sepsis is highest in low- and middle-income countries, though the management these settings poorly characterized. Therefore, objective this study was to assess early Thailand. Pre-planned analysis Ubon-sepsis study, a single-center prospective cohort Thai adults admitted general medical wards intensive care units (ICUs) regional referral hospital with community-acquired sepsis. Between March 2013 January 2017, 3,716 patients were enrolled. median age 59 years (IQR 44-72, range...
Melioidosis is a common community-acquired infectious disease in northeast Thailand associated with overall mortality of approximately 40% hospitalized patients, and over 70% severe cases. Ceftazidime recommended for parenteral treatment patients suspected melioidosis. Meropenem increasingly used but evidence to support this lacking. A decision tree was estimate the cost-effectiveness treating non-severe acute melioidosis cases either ceftazidime or meropenem. Empirical meropenem likely be...
Melioidosis, infection caused by Burkholderia pseudomallei, is a common cause of sepsis with high associated mortality in Southeast Asia. Identification patients at likelihood clinical deterioration important for guiding decisions about resource allocation and management. We sought to develop biomarker-based model 28-day prediction melioidosis.In derivation set (N = 113) prospectively enrolled, hospitalized Thai melioidosis, we measured concentrations interferon-γ, interleukin-1β,...
Rationale: The global burden of sepsis is greatest in low-resource settings. Melioidosis, infection with the gram-negative bacterium Burkholderia pseudomallei, a frequent cause fatal endemic tropical regions such as Southeast Asia. Objectives: To investigate whether plasma metabolomics would identify biological pathways specific to melioidosis and yield clinically meaningful biomarkers. Methods: Using comprehensive approach, differential enrichment metabolites was systematically evaluated...
Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying causative pathogen is essential not only effective personal treatment but also early detection outbreaks. The Defense Threat Reduction Agency (DTRA) tasked coalition commercial, academic, government researchers with moving diagnostic technology concepts ideation field use as rapidly possible using scientifically sound...