A5089444754- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Cytomegalovirus and herpesvirus research
- Single-cell and spatial transcriptomics
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Hemoglobinopathies and Related Disorders
- Complement system in diseases
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Chronic Myeloid Leukemia Treatments
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- Malaria Research and Control
- Protein Degradation and Inhibitors
- HIV Research and Treatment
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
National Center for Epidemiology
2022
BM Központi Kórház
2022
Unified Szent István and Szent László Hospital
2017-2019
Abstract The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of CLL, combining immune-phenotyping, single-cell transcriptome profiling, and chromatin mapping. We identify a consistent program starting sharp decrease NF-κB binding CLL cells, which is followed by reduced...
Abstract In the present study, humoral and T cell-mediated immune responses elicited by BBIBP-CorV (inactivated virus) BNT162b2 (mRNA-based) vaccines against SARS-CoV-2 virus were compared. Convalescent volunteers also investigated to evaluate adaptive immunity induced live virus. Although both antibody- responses, our analysis revealed significant quantitative qualitative differences between two types of challenges. The vaccine antireceptor-binding domain (RBD) IgG, as well anti-spike...
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib is inducing durable responses in chronic lymphocytic leukemia (CLL) patients with refractory/relapsed disease or TP53 defect, BTK and phospholipase C gamma 2 ( PLCG2 ) mutations representing the predominant mechanisms conferring secondary resistance. To understand landscape of genomic changes dynamics subclonal architecture associated treatment, an ultra‐deep next‐generation sequencing analysis 30 recurrently mutated genes was performed...
Viral reactivation is a frequent complication of allogeneic hematopoietic stem cell transplantation especially in children. For refractory cases, rapid virus-specific T-cell therapy would be ideally implemented within few days. Over the course year our pediatric cohort 43 transplantation, 9 patients fulfilled criteria for therapy. infections were due to cytomegalovirus (CMV) 3, Epstein-Barr virus (EBV) 2, and adenovirus (AdV) 1 case, whereas >1 was detected 3 cases. diseases necessitating...
Common variable immunodeficiency (CVID) patients have markedly decreased immune response to vaccinations. In this study we evaluated humoral and T cell-mediated responses against severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) with additional flow cytometric changes in CVID receiving booster vaccination BNT162b2 after two ChAdOx1 nCoV-19. The vaccine raised the anti-spike protein S immunoglobulin G over cut-off value from 70% 83% CVID, anti-neutralizing antibody had been a 80%...
Multiple myeloma (MM) is the second most common hematological malignancy. Approximately 15% of MM patients are affected by t(4;14) translocation resulting in IGH::NSD2 fusion transcript. Breakage occurs three major breakpoint regions within NSD2 gene (MB4-1, MB4-2, and MB4-3), where MB4-1 leads to production full-length protein, while truncated proteins expressed other two cases. Measurable residual disease (MRD) has been conclusively established as a crucial prognostic factor MM. The...
Background: Thrombotic microangiopathy (TMA) is a potentially life-threatening complication associated with carfilzomib, proteasome inhibitor approved for treating multiple myeloma. TMA typically presents within the initial months of treatment; however, delayed onset rare and poses significant diagnostic challenges. Methods: We conducted retrospective analysis medical records 47-year-old Caucasian woman diagnosed IgA kappa myeloma who developed signs symptoms consistent eleven after...
Abstract Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease. Despite this heterogeneity, the Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for vast majority of CLL patients. To define underlining regulatory program, we analyzed high-resolution time courses in closely monitored patients, combining cellular phenotyping (flow cytometry), single-cell transcriptome profiling (scRNA-seq), chromatin mapping...
Background and objectives Administration of virus‐specific T cells (VSTs) is a viable antiviral treatment strategy after allogeneic HSCT, even if conventional therapies fail. Third‐party donors are often chosen for the generation VST product. The eligibility donor has to be tested in rigorous screening procedure, since isolation technology only targets pre‐existing VSTs. Materials methods In period 3 years, we performed 32 treatments 28 patients. Targeting four different viruses, 284 healthy...
Abstract: Introduction and aim: The publication summarizes the 2548 stem cell transplantations performed in period of 1993-2015 Szent Laszló Hospital, Budapest provides a detailed discussion 425 allogeneic during 2007–2013. Method: analysis explains major steps evolution transplantation compares results unique Hungarian center. Results: significant shift indications from chronic myeloid leukemia to myelodysplastic syndromes rising age recipients are line with world wide tendencies. latter...
Background: The optimal approach for adult patients hospitalized with severe and critical coronavirus disease 2019 (COVID-19), non-responsive to antiviral immunomodulatory drugs, is not well established. Our aim was evaluate feasibility safety of extracorporeal photopheresis (ECP) in this setting. Methods: A prospective, single-center investigational study performed between 2021 2022 at a tertiary referral center COVID-19. Patients diagnosed COVID-19 were screened, cases or fulfilling...
Összefoglaló. Az autoimmun lymphoproliferativ szindróma egy ritka, immundeficientiával járó genetikai betegség. Hátterében az extrinszik apoptotikus útvonal génjeinek örökletes vagy szerzett mutációi és a következményesen kialakuló, aktivált lymphocyták negatív szelekciójának defektusa áll. klinikai megjelenésére jellemző jóindulatú lymphocytaburjánzás következtében kialakuló lymphadenopathia lépmegnagyobbodás. Gyakran társul olyan kórképekkel, mint haemolyticus anaemia thrombocytopenia. A...