A5013235914- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Clinical Laboratory Practices and Quality Control
- Cardiac Imaging and Diagnostics
- Alzheimer's disease research and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Cardiac and Coronary Surgery Techniques
- S100 Proteins and Annexins
- Oral microbiology and periodontitis research
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastroesophageal reflux and treatments
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Dysphagia Assessment and Management
- Inflammatory mediators and NSAID effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Muscle and Compartmental Disorders
- Exercise and Physiological Responses
- Immune Response and Inflammation
- Cardiac Ischemia and Reperfusion
- Sports Performance and Training
- Lipoproteins and Cardiovascular Health
- Genetics and Physical Performance
University of Ljubljana
2012-2025
Ljubljana University Medical Centre
2015-2025
Objectives Laryngopharyngeal reflux ( LPR ) and biliary duodenogastric can cause damage to the laryngeal mucosa voice disorders. The aim of this study was find out whether levels pepsin bile acids in saliva serve as diagnostic markers . Setting A prospective comparative study. Participants Twenty‐eight patients with proven via high‐resolution manometry combined multichannel intraluminal impedance 24‐h pH monitoring 48 healthy controls without symptoms were included Main outcome measures In...
The purpose of this randomised, single-centre study was to prospectively investigate the impact anaesthetic techniques for craniotomy on release cytokines IL-6, IL-8, IL-10, and determine whether intravenous anaesthesia compared inhalational attenuates inflammatory response.The enroled 40 patients undergoing craniotomy, allocated into two equal groups receive either sevoflurane (n = 20) or propofol in conjunction with remifentanil rocuronium. lungs were ventilated mechanically maintain...
Gastroesophageal reflux is suspected to be an etiological factor in laryngeal and pharyngeal cancer. The aim of this study was establish, using a non-invasive method, whether laryngopharyngeal (LPR) appears more often patients with early cancer than control group.We compared the pH, level bile acids, total pepsin enzymatic activity saliva group 30 T1 carcinoma 34 healthy volunteers.The groups differed significantly terms levels acids sample. Higher were detected patients. No significant...
Measurement of cardiac troponin in serum is an essential part diagnosing myocardial infarction the emergency department. The guidelines suggest that high-sensitivity techniques should be used for measuring I (cTnI) or T (cTnT). aim our study was to correlate values both troponins, and ascertain which type more agreement with diagnosis. patients were classified into four groups: 43 non-ST-elevation (NSTEMI), 7 ST-elevation (STEMI), 48 Type 2 infarction, 21 control group. A significant...
Introduction The aim of this study was to investigate the associations between subjective and objective measures stress load in elite male handball players at both group individual levels. Methods In 45-week prospective cohort study, 189 weekly reported their perceived across training, competition, academic, work domains. Blood samples were collected five times during 2022/23 season measure cortisol free testosterone ratio (FTCR). We derived a “load” variable as sum academic hours calculated...
Highlights:•Most laboratory parameters returned to reference values 6 months after COVID-19 infection•Values of certain still correlated with severity•Values suggest incomplete resolution renal, biliary tract, and immune system functionAbstractObjectivesDespite extensive study disease, only a few studies also addressed the aftermath disease potential long-term consequences. The aim this was assess through cross-sectional analysis an range haematological biochemical find markers associated...
Introduction Traumatic brain injury (TBI) is often associated with reduced cerebral blood flow and an increased inflammatory response, leading to secondary damage. Stellate ganglion block (SGB) has been shown improve hemodynamics in non-TBI, but its effects TBI are still unclear. Objective This prospective pilot study investigates the of SGB on neuroinflammatory responses patients moderate severe aim evaluating potential as a therapeutic intervention. Methods A prospective, single-center...
Neurocognitive decline during the perioperative period represents a risk of significant complications, including dementia and death. The aim our study was to observe change in biomarkers neuroinflammation optimized anesthesia without clinical signs neurocognitive decline. Observational included high-risk surgical patients who underwent large intestinal resections. Balanced anaesthesia used maximize cerebral protection. release NSE, protein S-100, matrix metalloproteinase-9 (MMP-9) other...
Exercise-associated iron deficiency is a common disorder in endurance athletes. The authors investigated the effects of long-term exercise on hepcidin concentrations, inflammatory parameters, and status moderately trained female long-distance runners. Eighteen runners were assigned to either an interval- or continuous-training group. physical training consisted two 3-week progressive overload periods, each followed by week’s recovery, concluded with 10- 21-km competitive run. Samples taken 6...
Background and Aims Exercise-induced iron deficiency is a common finding in endurance athletes. It has been suggested recently that hepcidin may be an important mediator this process. Objective To determine levels markers of status during long-term exercise training female runners with depleted normal stores. Methods Fourteen were divided into two groups according to status. Blood samples taken period eight weeks at baseline, after ten days' recovery phase. Results Of 14 runners, 7 deficient...
Extracorporeal hemadsorption may reduce inflammatory reaction in cardiopulmonary bypass (CPB) surgery. Glucocorticoids have been used during open-heart surgery for alleviation of systemic inflammation after CPB. We compared intraoperative and methylprednisolone, with usual care, complex cardiac on CPB, responses, hemodynamics, perioperative course. Seventy-six patients prolonged CPB were recruited randomized, 60 included final analysis. Allocation was into three groups: Methylprednisolone (n...
Endometrial cancer is the most common estrogen-dependent gynecological malignancy in developed World. To investigate local formation of estradiol (E2), we first measured concentrations steroid precursor androstenedione (A-dione) and potent estrogen, E2, evaluated metabolism A-dione, estrone-sulfate (E1-S), estrone (E1) cancerous adjacent control endometrium. Furthermore, studied expression key genes for via aromatase sulfatase pathways. A-dione E2 were detected In endometrium, was...
The aim of our study was to compare the total 25(OH)D fraction, bioavailable vitamin and free D fraction in spring fall a group healthy individuals.
To prospectively assess the antiinflammatory effect of volatile anesthetic sevoflurane in patients undergoing open lung surgery with one ventilation (OLV).This prospective, randomized study included 40 thoracic OLV (NCT02188407). The were randomly allocated into two equal groups that received either propofol or sevoflurane. Four excluded from because after they blood transfusion non-steroid drugs. Inflammatory mediators (interleukins 6, 8, and 10, C-reactive protein [CRP], procalcitonin)...
Single fiber electromyography (SFEMG) is the most sensitive diagnostic tool for diagnosis of myasthenia gravis (MG). Its prognostic value not known.We retrospectively analyzed clinical course 232 MG patients who presented with only mild symptoms and had SFEMG orbicularis oculi muscle. We correlated their results severity later course.During observation period 39 (17%) developed severe disease exacerbations, 193 (83%) remained stable. Patients exacerbation a significantly higher mean jitter...
40 individuals with type 1 diabetes (average age of 44.7 ± 2.5 years) were randomized into four groups: (1) control (placebo), (2) empagliflozin 25 mg daily, (3) metformin 2000 and (4) empagliflozin-metformin combination (25 respectively). At inclusion after 12 weeks treatment, the blood samples collected, oxidative stress (total antioxidative status (TAS), superoxide dismutase (SOD), glutathione peroxidase (GPx), uric acid, advanced oxidation protein products (AOPP), glycosylation end...
Sugammadex reverses neuromuscular block (NMB) through binding aminosteroid blocking agents. Although sugammadex appears to be highly selective, it can interact with other drugs, like corticosteroids. A prospective single-blinded randomized clinical trial was designed explore the significance of interactions between dexamethasone and sugammadex. Sixty-five patients who were anesthetized for elective abdominal or urological surgery included. NMB assessed using train-of-four stimulation (TOF),...
Abstract Acute kidney injury (AKI) represents frequent complication after cardiac surgery using cardiopulmonary bypass (CPB). In the hope to enhance earlier more reliable characterization of AKI, we tested utility neutrophil gelatinase‐associated lipocalin (NGAL) and cystatin C (CysC) in addition standard creatinine for early determination AKI CPB. Forty‐one patients met inclusion criteria. Arterial blood samples collected induction general anesthesia were used as baseline, further sampling...