A5071742424- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
The University of Adelaide
2013-2022
Abstract IL-17-producing helper T (Th17) cells are critical for host defense against extracellular pathogens but also drive numerous autoimmune diseases. Th17 that differ in their inflammatory potential have been described including IL-10-producing weak inducers of inflammation and highly inflammatory, IL-23-driven, GM-CSF/IFNγ-producing cells. However, distinct developmental requirements, functions trafficking mechanisms vivo remain poorly understood. Here we identify a temporally regulated...
Abstract Interleukin 17-producing γδ T (γδT17) cells have unconventional trafficking characteristics, residing in mucocutaneous tissues but also homing into inflamed via circulation. Despite being fundamental to γδT17-driven early protective immunity and exacerbation of autoimmunity cancer, migratory cues controlling γδT17 cell positioning barrier recruitment inflammatory sites are still unclear. Here we show that constitutively express chemokine receptors CCR6 CCR2. While recruits resting...
Abstract Migration of Th cells to peripheral sites inflammation is essential for execution their effector function. The recently described Th9 subset characteristically produces IL-9 and has been implicated in both allergy autoimmunity. Despite this, the migratory properties remain enigmatic. In this study, we examined chemokine receptor usage by demonstrate, models autoimmunity, that these express functional CCR3, CCR6, CXCR3, receptors commonly associated with other, functionally opposed...
Significance The immune system relies on coordinated interactions between motile cells guided by molecules known as chemokines. However, processes that control chemokine distribution in complex vivo microenvironments are poorly understood. Dendritic barrier tissues require the CCL21 to enter lymphatic vessels during tissue egress. Here, we demonstrate ACKR4 shapes and prevents leakage of from tissue. Without ACKR4, extracellular gradients sites saturated nonfunctional, DCs cannot home...
Glioblastoma is the most common and aggressive form of primary brain cancer, with no improvements in 5-year survival rate 4.6% over past three decades. T-cell-based immunotherapies such as immune-checkpoint inhibitors chimeric antigen receptor T-cell therapy have prolonged patients other cancers undergone early-phase clinical evaluation glioblastoma patients. However, a major challenge for immunotherapy solid infiltration into tumours. This process mediated by chemokine-chemokine...
Activated B cells can initially differentiate into three functionally distinct fates—early plasmablasts (PBs), germinal center (GC) cells, or early memory cells—by mechanisms that remain poorly understood. Here, we identify atypical chemokine receptor 4 (ACKR4), a decoy binds and degrades CCR7 ligands CCL19/CCL21, as regulator of activated cell differentiation. By restricting initial access to splenic interfollicular zones (IFZs), ACKR4 limits the proliferation reducing numbers available for...
Follicular T cells including follicular helper (TFH) and regulatory (TFR) are essential in supporting regulating the quality of antibody responses that develop germinal centre (GC). cell migration during propagation is largely attributed to chemokine receptor CXCR5, however CXCR5 reportedly redundant migratory events prior formation GC, CXCR5-deficient TFH TFR still capable localizing GCs. Here we comprehensively assess expression by a model humoral immune response spleen. In addition known...