A5046810825- Characterization and Applications of Magnetic Nanoparticles
- Geomagnetism and Paleomagnetism Studies
- Minerals Flotation and Separation Techniques
- Electrical and Bioimpedance Tomography
- Nanoparticle-Based Drug Delivery
- Magnetic properties of thin films
- Advanced MRI Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Erythrocyte Function and Pathophysiology
- NMR spectroscopy and applications
University Medical Center Hamburg-Eppendorf
2022-2025
Universität Hamburg
2021-2025
Hamburg University of Technology
2021-2025
The effect of particle interactions on the signal stability magnetic imaging (MPI) and spectroscopy is analyzed. We show that our pre-aggregated flame-made nanoparticles outperform a commercial agglomerating MPI tracer.
Abstract In the field of medical imaging, magnetic particle imaging (MPI) poses a promising non-ionizing tomographic technique with high spatial and temporal resolution. MPI, iterative solvers are used to reconstruct distribution out measured voltage signal based on system matrix. The amount regularization needed an image good quality differs from measurement measurement, depending MPI settings. Finding right choice for three major parameters controlling is commonly done by hand requires...
New possibilities offered by Magnetic Particle Spectroscopy (MPS) and Imaging (MPI) are increasingly being recognized may accelerate the introduction of MPI into clinical settings. As is a tracer-based imaging method, design development responsive tracers for functional particularly appealing. Here, we report on Mn-ferrite (MnxFe3-xO4) nanoparticles with finely tuned magnetic properties enzyme-like capabilities as potential multifunctional theranostic agents. By adjusting Mn content in iron...
The application of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, magnetic resonance imaging, cell tracking, and hyperthermia has been long exploited regarding their inducible properties. Nevertheless, SPIONs remain rapidly cleared from the circulation by reticuloendothelial system (RES) or mononuclear phagocyte system, with uptake dependent on several factors such as hydrodynamic diameter, electrical charge surface coating. This rapid clearance SPION-based theranostic...
Magnetic particle imaging exploits the non-linear magnetization of superparamagnetic iron-oxide particles to generate a tomographic image in defined field-of-view. For reconstruction distribution, time-consuming calibration step is required, which system matrices get measured using robot. To achieve artifact-free images, need cover not only field-of-view but also larger area around it. Especially for large measurements- inevitable future clinical application- this leads long time and high...
Objective. The availability of magnetic nanoparticles with medical approval for human intervention is fundamental to the clinical translation particle imaging (MPI). In this work, we thoroughly evaluate and compare properties an resonance (MRI) approved tracer validate its performance MPI in future trials. Approach. We analyze whether recently MRI Resotran suitable MPI. addition, previously extensively studied Resovist, Ferrotran, which currently a phase III study, tailored Perimag. Main...
Magnetic particle imaging is a tracer-based tomographic technique that allows the concentration of magnetic nanoparticles to be determined with high spatio-temporal resolution. To reconstruct an image tracer concentration, magnetization dynamics particles must accurately modeled. A popular ensemble model based on solving Fokker-Plank equation, taking into account either Brownian or N\'eel dynamics. The disadvantage this it computationally expensive due underlying stiff differential equation....
Abstract Objective. The availability of magnetic nanoparticles (MNPs) with medical approval for human intervention is fundamental to the clinical translation particle imaging (MPI). In this work, we thoroughly evaluate and compare properties an resonance (MRI) approved tracer validate its performance MPI in future trials. Approach. We analyze whether recently MRI Resotran suitable MPI. addition, previously extensively studied Resovist, Ferrotran, which currently a phase III study, tailored...
Abstract Tracer and thus signal stability is crucial for an accurate diagnosis via magnetic particle imaging (MPI). However, MPI-tracer nanoparticles frequently agglomerate during their in vivo applications leading to interactions. Here, we investigate the influence of such coupling phenomena on MPI signal. We prepared characterized Zn 0.4 Fe 2.6 O 4 controlled interparticle distance by variying SiO 2 coating thickness. The silica shell affected properties indicating stronger interactions a...