A5038625029- Characterization and Applications of Magnetic Nanoparticles
- Geomagnetism and Paleomagnetism Studies
- Microfluidic and Bio-sensing Technologies
- Electrical and Bioimpedance Tomography
- Micro and Nano Robotics
- Magnetic properties of thin films
- Minerals Flotation and Separation Techniques
- Advanced MRI Techniques and Applications
- Acoustic Wave Resonator Technologies
- Magnetic Properties and Applications
- Particle accelerators and beam dynamics
- Advanced MEMS and NEMS Technologies
- Electric Motor Design and Analysis
- Microwave Engineering and Waveguides
- Cardiovascular Health and Disease Prevention
- Energy Harvesting in Wireless Networks
- Electrostatics and Colloid Interactions
- Advanced Materials Characterization Techniques
- Nanoparticle-Based Drug Delivery
- Radio Frequency Integrated Circuit Design
Universität Hamburg
2018-2025
Hamburg University of Technology
2018-2025
University Medical Center Hamburg-Eppendorf
2019-2025
Abstract Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there a high risk restenosis or rebleeding that patients need intense attention in days treatment. Within this work, we present diagnostic tomographic imager allows access to quantitatively short intervals. The device based on magnetic particle imaging technology designed human scale. It highly sensitive detection...
Magnetic particle imaging (MPI) is an innovative radiation-free tomographic method providing excellent temporal resolution, contrast, sensitivity, and safety. Mobile human MPI prototypes suitable for continuous bedside monitoring of whole-brain perfusion have been developed. However, the clinical translation MPI, a crucial gap in knowledge still remains: while can visualize reduction blood flow tissue cerebral ischemia, it unclear whether works intracranial hemorrhage. Our objective was to...
Abstract Since the initial patent in 2001, Magnetic Particle Imaging community has endeavored to develop a human-applicable scanner, incorporating contributions from various research fields. Here we present an improved head-sized scanner with low power consumption, operated by open-source software and characterize it emphasis on human safety. The focus is evaluation of technical components phantom experiments for brain perfusion. We achieved 3D single- multi-contrast imaging at 4 Hz frame...
Passive wireless sensors are crucial in modern medical and industrial settings to monitor procedures conditions. We demonstrate a circuit inductively excite passive resonators conduct their decaying signal response low noise amplifier. Two design variations of generic transmit-receive chain proposed, measured, described detail for the purpose facilitating replication. Instrumentation aim be scalable multi-channel array configurations, using either off-the-shelf class-D audio amplifiers or...
New possibilities offered by Magnetic Particle Spectroscopy (MPS) and Imaging (MPI) are increasingly being recognized may accelerate the introduction of MPI into clinical settings. As is a tracer-based imaging method, design development responsive tracers for functional particularly appealing. Here, we report on Mn-ferrite (MnxFe3-xO4) nanoparticles with finely tuned magnetic properties enzyme-like capabilities as potential multifunctional theranostic agents. By adjusting Mn content in iron...
Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis isotonic resealing procedure. amounts oxide incorporated RBCs were determined Fe quantification using nuclear...
The effect of particle interactions on the signal stability magnetic imaging (MPI) and spectroscopy is analyzed. We show that our pre-aggregated flame-made nanoparticles outperform a commercial agglomerating MPI tracer.
Magnetic Particle Imaging (MPI) is a novel and versatile imaging modality developing towards human application. When up-scaling to size, the sensitivity of systems naturally drops as coil depends on bore diameter. Thus, new methods push limit further have be investigated cope for this loss. In paper dedicated surface mice developed, improving in cerebral applications. Similar MRI developed improves due closer vicinity region interest. With presented work, it possible image tracer samples...
Magnetic nanoparticles are a valuable tool in many biomedical applications and can be used for diagnostic therapeutic purposes. In magnetic particle imaging (MPI) spectroscopy (MPS), the particles subjected to dynamic field magnetization response is simultaneously measured using one or multiple receive coils. Separating signal from feed-through commonly done by advanced passive filtering, which distorts signal. To correct this distortion, transfer function of chain needs known. While...
Improving resolution and sensitivity will widen possible medical applications of magnetic particle imaging. Pulsed excitation promises such benefits, at the cost more complex hardware solutions restrictions on drive field amplitude frequency. State-of-the-art systems utilize a sinusoidal to superparamagnetic nanoparticles into non-linear part their magnetization curve, which creates spectrum with clear separation direct feed-through higher harmonics caused by particles response. One...
In magnetic particle imaging, a field-free region is maneuvered throughout the field of view using time-varying known as drive-field. Human-sized systems operate drive-field in kHz range and generate it by utilizing strong currents that can rise to kA within coil called drive generator. Matching tuning between power amplifier, band-pass filter, generator required. Here, for reasons safety future human scanners, symmetrical topology transformer an inductive coupling network are used. Our...
Magnetic Particle Imaging has proven to resolve superparamagnetic nano-particles within 3D volumes with high sensitivity and temporal resolution. Lately, MPI was utilized track, manipulate navigate small ferromagnetic devices since the magnetic field topology for imaging is very suitable generating magnetical forces. In this work, we demonstrate ability image move micro-sized beads simultaneously MPI. We are constantly switching between force mode position their movement. Beside imaging,...
Objective. The availability of magnetic nanoparticles with medical approval for human intervention is fundamental to the clinical translation particle imaging (MPI). In this work, we thoroughly evaluate and compare properties an resonance (MRI) approved tracer validate its performance MPI in future trials. Approach. We analyze whether recently MRI Resotran suitable MPI. addition, previously extensively studied Resovist, Ferrotran, which currently a phase III study, tailored Perimag. Main...
Abstract Objective. The availability of magnetic nanoparticles (MNPs) with medical approval for human intervention is fundamental to the clinical translation particle imaging (MPI). In this work, we thoroughly evaluate and compare properties an resonance (MRI) approved tracer validate its performance MPI in future trials. Approach. We analyze whether recently MRI Resotran suitable MPI. addition, previously extensively studied Resovist, Ferrotran, which currently a phase III study, tailored...
Abstract Determining the position and orientation of a medical instrument is essential for accurate procedures in endoscopy, surgery, vascular interventions. Recently, novel sensor based on torsional pendulum-like magneto-mechanical motion has been proposed. This passive, wireless inductively coupled to transmit-receive coil array. setup allows determination all 6 degrees freedom using characteristic resonance sensor. Additional physical quantities such as temperature pressure can be...
Magnetic particle imaging is a very useful tool in the detection of stroke. To study ability stroke mouse model data acquisition challenging as brain contains only small ratio blood compared to large animals or humans. The effective concentration within whole organ therefore small, especially heart liver. Typical MPI receiver coils however cover sensitive region around 30 mm 50 mm and have bore size above 40 mm. This leads on one hand non-optimal signal coupling due distance particles other...
In Magnetic Particle Imaging, a field-free region is maneuvered throughout the field of view using time-varying magnetic known as drive-field. Human-sized systems operate drive-field in kHz range and generate it by utilizing strong currents that can rise to kA within coil called drive generator. Matching tuning between power amplifier, band-pass filter generator required. Here, for reasons safety future human scanners, symmetrical topology transformer, inductive coupling network used. Our...
Since the initial patent in 2001, Magnetic Particle Imaging (MPI) community has been striving to develop an MPI scanner suitable for human applications. Numerous contributions from different research fields, regarding tracer development, reconstruction methods, hardware engineering, and sequence design have employed pursuit of this objective. In work, we introduce thoroughly characterize improved head-sized with emphasis on safety. The is operated by open-source software that enables...