A5059024560- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
- Sesquiterpenes and Asteraceae Studies
- Phytochemical compounds biological activities
- Traditional Chinese Medicine Analysis
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
- Plant-derived Lignans Synthesis and Bioactivity
- Natural Antidiabetic Agents Studies
- Analytical chemistry methods development
- Plant Toxicity and Pharmacological Properties
- Bone Metabolism and Diseases
- Free Radicals and Antioxidants
- Fungal Biology and Applications
- Synthesis and bioactivity of alkaloids
- Bioactive natural compounds
- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Bone health and treatments
- Phytochemical Studies and Bioactivities
- Plant biochemistry and biosynthesis
Institute of Tibetan Plateau Research
2014-2023
Qinghai Tibetan Hospital
2017-2023
Northwest Institute of Plateau Biology
2016-2023
Chinese Academy of Sciences
2013-2022
Xinjiang Institute of Ecology and Geography
2006-2022
Beijing Research Center for Agricultural and Standards and Testing
2019
Beijing Municipal Ecological and Environmental Monitoring Center
2019
Chung Shan Medical University
2019
State Council of the People's Republic of China
2015
Simultaneous detection of oleanolic acid and ursolic in rat blood by vivo microdialysis can provide important pharmacokinetics information. Microwave-assisted derivatization coupled with magnetic dispersive solid phase extraction was established for the determination liquid chromatography tandem mass spectrometry. 2'-Carbonyl-piperazine rhodamine B first designed synthesized as reagent, which easily adsorbed onto surface Fe3O4/graphene oxide. were performed on The permanent positive charge...
The preparative separation of anthocyanins by HPLC often suffers from insufficient selectivity.
Lycium ruthenicum Murr. (LRM, Solanaceae), also called "black wolfberry" in China, is extremely tolerant drought. Although black wolfberry has seeds that are rich oil, being considered as a potential alternative for edible oil production, little information been found regarding its characterization. The present study evaluated the fatty acid profile of seed and phytosterol contents. Moreover, antioxidant inhibition activities on pancreatic lipase, cholesterol esterase (CEase) were...
Traditional Tibetan medicine is important for discovery of drug precursors. However, knowledge the chemical composition traditional medicines very limited due to lack appropriate chromatographic purification methods. In present work, Salvia prattii was taken as an example, and off-line hydrophilic interaction liquid chromatography/reversed-phase chromatography preparative method developed phenylpropanoids with high purity from a crude sample prattii. Based on separation results four...
Endocrine-disrupting chemicals (EDCs) in environment samples and food stuffs are an increasing serious public health issue due to their potency interfere deregulate several aspects of the endocrine system. Because extremely low abundance, it remains a challenging task develop sensitive detection method.4'-Carbonyl chloride rosamine (CCR) was used as derivatization reagent for EDCs first time. A new ultrasound-assisted situ derivatization/dispersive liquid-liquid microextraction (UA-DLLME...
Bioactive equivalent combinatorial components play a critical role in herbal medicines. However, how to discover and enrich them efficiently is question for pharmaceuticals researchers. In our work, novel two-dimensional reversed-phase/hydrophilic interaction high-performance liquid chromatography method was established perform real-time trapping combining preparation isolation of coeluting components. Arenaria kansuensis taken as an example, solid-phase extraction coupled with liquid–liquid...
An offline preparative two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography coupled with hydrophilic solid-phase extraction method was developed for the isolation of flavonoid glycosides from a crude sample Sphaerophysa salsula. First, non-flavonoids were removed using an XAmide cartridge. Based on separation results three different chromatographic stationary phases, first-dimensional preparation performed XAqua C18 prep column, and 15 fractions...
Rhodiola crenulata (HK. f. et. Thoms) H. Ohba (RC), mainly distributed in the highly cold region of China, has long been used as a medicine/healthy food for eliminating fatigue and increasing blood circulation. This study aimed to evaluate inhibitory effects RCRS extract on α-amylase α-glucosidase (sucrase maltase) vitro vivo, tentatively analyze identify its chemical ingredients using UPLC-Triple-TOF/MS. The had strong activities against α-amylase, sucrase maltase with an IC50 0.031 mg...
The separation of high-purity compounds from traditional Tibetan medicines plays an important role in investigating their bioactivity. Nevertheless, it is often quite difficult to isolate with high purity because the complexity medicines. In this work, offline two-dimensional reversed-phase preparative method was successfully developed for Oxytropis falcata. Based on analysis results, ODS C18 prep column used first-dimensional preparation, and 14.8 g crude sample separated into five...
Abstract An orthogonally (80.3%) preparative two‐dimensional hydrophilic interaction chromatography/reversed‐phase liquid chromatography method has been established for the isolation and purification of flavonoids from Saxifraga tangutica . Initially, were enriched by means a middle‐pressure chromatographic tower (containing middle chromatogram isolated gel). In first dimension, XION column was used to separate flavonoid fractions under guidance characteristic ultraviolet absorption spectra...
The lack of suitable chromatographic purification methods makes it a challenge to effectively isolate the chemical components traditional Tibetan medicines. Ribes himalense is rarely studied medicine, reputed have free radical-scavenging effects. In present work, we utilized as model herb highlight an approach for separation 1,1-diphenyl-2-picrylhydrazyl inhibitors via medium-pressure chromatography and two-dimensional reversed-phase/reversed-phase interaction liquid under guidance online...