A5005838780- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Estrogen and related hormone effects
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- melanin and skin pigmentation
- Plant Gene Expression Analysis
- Cancer-related gene regulation
- Nuclear Receptors and Signaling
- Enzyme Structure and Function
- MicroRNA in disease regulation
- Fungal and yeast genetics research
- Bone and Joint Diseases
- Birth, Development, and Health
- Protein Degradation and Inhibitors
- Cardiovascular Function and Risk Factors
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Inflammatory mediators and NSAID effects
- Bioinformatics and Genomic Networks
- Bacterial Genetics and Biotechnology
Universidade Estadual de Campinas (UNICAMP)
2019-2024
Centre National de la Recherche Scientifique
2011
Aix-Marseille Université
2011
Université de Montréal
2002-2009
Institute for Research in Immunology and Cancer
2007-2008
Exposure of Escherichia coli to UV light increases expression NrdAB, the major ribonucleotide reductase leading a moderate increase in dNTP levels. The role elevated levels during translesion synthesis (TLS) across specific replication-blocking lesions was investigated. Here we show that although specialized DNA polymerase PolV is necessary for replication UV-lesions, such as cyclobutane pyrimidine dimers or pyrimidine(6-4)pyrimidone photoproduct, Pol V per se not sufficient. Indeed,...
The bulky side chains of antiestrogens hinder folding the ligand binding domain (LBD) estrogen receptors (ERs) into a transcriptionally active conformation. presence tertiary amine in chain raloxifene, which interacts with negatively charged residue helix H3 ER LBD [Asp351 human (h)ERalpha], is important for antiestrogenicity animal and cellular models. To better understand molecular basis differential activity tamoxifen we have examined influence substituents mutations at position 351...
Iodine-meta-iodobenzylguanidine scintigraphy is useful for assessing cardiac autonomic dysfunction and predict outcomes in heart failure (HF). The relationship of sympathetic function with myocardial remodeling diffuse fibrosis remains largely unknown. We aimed to evaluate the patients HF its relation exercise capacity.
Histone deacetylase inhibitors (HDACi), which have emerged as a new class of anticancer agents, act by modulating expression genes controlling apoptosis or cell proliferation. Here, we compared the effect HDACi on transcriptional activation estrogen glucocorticoid receptors (ER and GR, respectively), two members steroid receptor family with growth regulatory properties. Like other transcription factors, modulate histone acetylation target promoters. Using episomal reporter vectors containing...
This study compared clinical, echocardiographic, and prognostic characteristics among patients with aortic dissection (AD) (HypHist) without (No-HypHist) hypertension history evaluated the association of blood pressure (BP) at presentation 1-year mortality, left ventricular (LV) remodeling renal dysfunction.We investigated clinical echocardiographic mortality 367 AD (81% HypHist, 66% Type-A) from three Brazilian centers.Patients No-HypHist were more likely to have Marfan syndrome, bicuspid...
Although artificial C2-H2 zinc fingers can be designed to recognize specific DNA sequences, it remains unclear which extent nuclear receptor C4 tailored bind novel elements. Steroid receptors as dimers palindromic response elements differing in the two central base pairs of repeated motifs. Predictions based on one amino acid—one base-pair relationships may not apply estrogen (ERs), (EREs) via charged acids, each contacting bases opposite strands. Mutagenesis these residues, E203 and K210...
Background This study compared left ventricular (LV) characteristics between patients with type-A and type-B aortic dissection (AD) evaluated the ability of LV remodeling phenotypes (hypertrophy, concentricity, or geometric patterns) to predict mortality in both AD types. Methods Results We 236 type A 120 B who had echocardiograms within 60 days before after diagnosis (median [25th, 75th percentiles] time difference echocardiogram diagnosis=1 [0, 6] days) from 3 centers. Patients were...
Aims Patients with aortic dissection have a high prevalence of left ventricular structural alterations, including hypertrophy (LVH), but little is known about the impact sex on this regard. This study compared clinical, cardiac, and prognostic characteristics between men women dissection. Methods We retrospectively assessed clinical echocardiographic characteristics, 1-year mortality in 367 patients (30% women; 66% Stanford-A) who underwent echocardiography 60 days before or after diagnosis...
Histone actyltransferase (HAT) enzymes form a superfamily of proteins that transfer an acetyl group from the acetyl‐coenzyme A (Ac‐CoA) cofactor to epsilon amino histone or sometimes non‐histone promote gene activation. Paradoxally, despite similar chemistry carried out by these enzymes, and their structurally related core regions, they fall into subfamilies with very limited no sequence homology, divergent flanking regions use mechanisms for catalysis. Four well studied HAT families include...
A dissecção da aorta é uma emergência médica caracterizada pelo desenvolvimento agudo de delaminação na túnica íntima, permitindo falsa luz e fluxo sanguíneo média. Vários estudos têm sugerido que a presença se associa com alterações estrutura cardíaca, particularmente, hipertrofia ventricular esquerda (HVE). Estes dados indicam as aórticas cardíacas possam compartilhar mecanismos fisiopatológicos comuns. Há ainda sugerindo relações entre o remodelamento vascular cardíaco em homens mulheres...