A5076989813- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Ion Transport and Channel Regulation
- Ion channel regulation and function
- Neurological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Sepsis Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- MicroRNA in disease regulation
- Intracranial Aneurysms: Treatment and Complications
- S100 Proteins and Annexins
- Cardiac Arrest and Resuscitation
- Takotsubo Cardiomyopathy and Associated Phenomena
- Inorganic Fluorides and Related Compounds
- Atrial Fibrillation Management and Outcomes
- Peripheral Neuropathies and Disorders
- Diabetic Foot Ulcer Assessment and Management
- Hereditary Neurological Disorders
- Social Media in Health Education
- Respiratory Support and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Thermal Regulation in Medicine
- Advanced Memory and Neural Computing
Medical University of South Carolina
2019-2024
University of Pennsylvania
2015-2016
University of Alabama at Birmingham
2006-2015
National Institute of Neurological Disorders and Stroke
2015
Vanderbilt University
2015
University of Tennessee at Knoxville
2015
Institute of Neurobiology
2008-2011
Sorbonne Université
2011
Centre National de la Recherche Scientifique
2011
Hanseo University
2011
This article traces the history of peer review scientific publications, plotting development process from its inception to present-day application. We discuss merits and weaknesses, both perceived real, as well practicalities several major proposed changes system. It is our hope that readers will gain a better appreciation complexities and, when serving reviewers themselves, do so in manner enhance utility exercise. also propose an international on-line training program for accreditation...
To identify endoplasmic reticulum (ER) stress-induced microRNAs (miRNA) that govern ER protein influx during the adaptive phase of unfolded response, we performed miRNA microarray profiling and analysis in human airway epithelial cells following stress induction using proteasome inhibition or tunicamycin treatment. We identified miR-346 as most significantly induced by both classic stressors. is encoded within an intron glutamate receptor ionotropic delta-1 gene (GRID1), but its...
High grade gliomas such as glioblastoma multiforme express multiple members of the epithelial sodium channel (ENaC)/Degenerin family, characteristically displaying a basally active amiloride-sensitive cation current not seen in normal human astrocytes or lower gliomas. Using quantitative real time PCR, we have shown higher expression ASIC1, alphaENaC, and gammaENaC D54-MG cells compared with primary astrocytes. We hypothesize that this glioma is mediated by hybrid composed mixture ENaC...
A variety of biological pro-health activities have been reported for mangiferin and hesperidin, two major phenolic compounds Honeybush (Cyclopia sp.) tea extracts. Given their increasing popularity, there is a need understanding the mechanisms underlying effects these compounds. In this study, we used real-time cytotoxicity cellular analysis Cyclopia sp. extracts on HeLa cells found that higher hesperidin content in non-fermented "green" correlated with compared to fermented We also had...
Glioblastoma multiforme (GBM) is the most common and aggressive of primary brain tumors. These tumors express multiple members epithelial sodium channel (ENaC)/degenerin (Deg) family are associated with a basally active amiloride-sensitive cation current. We hypothesize that this glioma current mediated by hybrid composed mixture ENaC acid-sensing ion (ASIC) subunits. To test hypothesis ASIC1 interacts αENaC γENaC at cellular level, we have used total internal reflection fluorescence...
Systemic inflammatory response syndrome (SIRS) is a generalized state. The primary goal of the study was to determine whether differences exist in outcomes SIRS and non-SIRS intravenous tissue-type plasminogen activator-treated patients.Consecutive patients were retrospectively reviewed for evidence during their admission. defined as presence ≥2 following: body temperature<36°C or >38°C, heart rate>90, respiratory rate>20, white blood cells<4000/mm >12 000 mm, >10% bands. Patients diagnosed...
Human acid-sensing ion channel 1b (hASIC1b) is a H(+)-gated amiloride-sensitive cation channel. We have previously shown that glioma cells exhibit an conductance. Amiloride and the ASIC1 blocker psalmotoxin-1 decrease migration proliferation of cells. PKC also abolishes conductance inhibits hASIC1b open probability in planar lipid bilayers. In addition, hASIC1b's COOH terminus has been to interact with protein interacting C kinase (PICK)1, which targets plasma membrane. Therefore, we tested...
Background. Symptomatic intracerebral hemorrhage (sICH) remains the most feared complication of intravenous tissue plasminogen activator (IV tPA) treatment. We aimed to investigate how previously validated scoring methodologies would perform in treated patients two US Stroke Belt states. Methods and Results. retrospectively reviewed consecutive from centers states who received IV tPA (2008–2011). assessed ability three models predict sICH. sICH was defined as a type 2 parenchymal with...
An association between Guillain-Barre syndrome and its variants (GBS/V) vaccines has led to hesitancy toward vaccination. COVID-19 could theoretically provoke GBS/V via immune activation. We analyzed reports of after vaccination in the vaccine adverse event reporting system (VAERS).The VAERS database is a surveillance used report events USA, open for consumers physicians access. It was queried following Reports were reviewed by four neurologists. Modified diagnostic criteria classify into...
To determine if direct admission of status epilepticus (SE) patients to a comprehensive epilepsy center (CEC) is associated with improved outcome compared community hospital subsequent CEC transfer.
Background & Purpose: sICS is a common mechanism for acute ischemic stroke (AIS), believed to preferentially affect Asians and Blacks compared Whites. In the U.S., reported rates of regions other than Stroke Belt are 17% among hospitalized 9% Whites with AIS. We aimed determine rate patients treated at our Southeastern U.S. center. Subjects Methods: Consecutive AIS receiving IV tPA admitted tertiary center were routinely evaluated presence intracranial stenosis (≥50% diameter reduction...
Background: Administration of IV tPA has traditionally necessitated admission to an ICU solely for monitoring, with relatively no need extensive critical care services. Stroke Units that are capable monitoring patients have been proposed reduce use, but limited data exist demonstrate safety. We report the largest series non-ICU managed cases in relation safety and discharge outcomes. Methods: Consecutive admitted our intermediate-level Unit spanning 2009-2011 were assembled. capabilities...
Objective: To examine the relationship between SIRS and outcomes in patients presenting with primary intracerebral hemorrhage (ICH). Background: Systemic Inflammatory Response Syndrome (SIRS) has been identified as a predictor of poor functional outcome at discharge acute ischemic stroke patients. Methods: A retrospective review consecutive to tertiary care center from 2008-2013 ICH.SIRS was defined according standard criteria having 2 or more following: (1) body temperature 38°C, (2) heart...
The drip and ship model is a method used to deliver thrombolysis acute stroke patients in facilities lacking onsite neurology coverage. We sought determine whether our population differs from treated directly at center (direct presenters).
OBJECTIVE: To assess patient selection biases for drip and ship thrombolysis compared to those treated at our stroke center (direct presenters).
High grade glioma cells express constitutively active inward Na+ currents that are inhibited by amiloride and psalmotoxin 1, implicating Epithelial channels (ENaCs) Acid Sensitive Ion Channels (ASICs) as core components of the channel. ASIC ENaC subunits have been detected in normal glia using rtPCR, but functional subunit composition channel remains unknown. In order to determine if intermix form heteromeric channels, intersubunit associations were measured confocal fluorescence resonant...
Background and Purpose: Systemic Inflammatory Response Syndrome (SIRS) has been identified as a predictor of poor functional outcome at discharge in acute ischemic stroke patients treated with tPA. We sought to examine the relationship between SIRS outcomes presenting primary intracerebral hemorrhage (ICH). Methods: A retrospective review consecutive tertiary care center from 2008-2013 ICH was conducted. Demographic clinical data were collected for analysis. Patients who placed on comfort or...