A5048833263- TGF-β signaling in diseases
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Immune Response and Inflammation
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- interferon and immune responses
- Immune Cell Function and Interaction
- Medical and Health Sciences Research
- Cytokine Signaling Pathways and Interactions
- Hedgehog Signaling Pathway Studies
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
The University of Tokyo
2009-2025
University of Tokyo Hospital
2021-2024
NTT Medical Center
2018-2024
Kansai University
2020
Tokyo Teishin Hospital
2018-2019
Tokyo University of Science
2013
The eradication of tumor cells requires communication to and signaling by the immune system. Natural killer (NK) are essential tumor-killing effector innate system; however, little is known about whether or how other recognize assist NK cells. Here, we show that receptor Dectin-1 expressed on dendritic macrophages critical NK-mediated killing express N-glycan structures at high levels. Receptor recognition these causes activation IRF5 transcription factor downstream gene induction for...
Significance The high-mobility group box 1 (HMGB1) protein is abundantly expressed in the nucleus where it regulates chromatin function. More recently, was found to also function cytoplasm and extracellular milieu for regulation of immunity inflammation. However, vivo study HMGB1 has been hampered by fact that HMGB1-deficient mice die soon after birth. In this study, we successfully generated Hmgb1 -floxed achieve conditional inactivation gene a cell- tissue-specific manner. We demonstrate...
Although the concept of cancer stem cells or cancer-initiating had created a new paradigm for treatment malignant tumors, it remains unclear how can be eradicated. We have previously reported that transforming growth factor-β (TGF-β)-Sox4-Sox2 pathway is essential glioma-initiating to retain their stemness, and inhibition TGF-β signaling may lead differentiation (Ikushima, H., Todo, T., Ino, Y., Takahashi, M., Miyazawa, K., Miyazono, K. (2009) Cell Stem 5, 504-514). Here we demonstrate Oct4...
Transforming growth factor-β (TGF-β) signaling is controlled by a variety of regulators, which Smad7, c-Ski, and SnoN play pivotal role in its negative regulation. Arkadia RING-type E3 ubiquitin ligase that targets these regulators for degradation to enhance TGF-β signaling. In the present study we identified candidate human tumor suppressor gene product RB1CC1/FIP200 as novel positive regulator functions substrate-selective cofactor Arkadia. Overexpression RB1CC1 enhanced signaling,...
Significance Infection by a given pathogen results in stimulation of multiple classes innate receptors cell, leading to activation distinct signaling pathways. However, these pathways are not always beneficial immune response against the pathogen. This study shows that, on infection pathogenic bacterium Listeria monocytogenes , Toll-like receptor (TLR) suppress type I IFN gene induction that is mediated stimulator genes. Type IFNs critical for antiviral immunity but detrimental macrophage...
Lung spindle cell carcinoma is a rare lung tumour with poor prognosis, and its standard therapy has not been established. Furthermore, little work conducted on the genetic characteristics of carcinomas. Here, we report an 82-year-old woman who was referred to our hospital due fever dyspnoea. Chest computed tomography demonstrated 75-mm mass surrounded by infiltrates atelectasis in right upper lobe. She eventually diagnosed corresponding clinical stage IVB (cT4N2M1c(ADR)). A study indicated...
GCIP/HHM is a human nuclear protein that implicated in regulation of cell proliferation. Its primary structure contains helix–loop–helix and leucine-zipper motifs but lacks DNA-binding basic region. Native selenomethionine-derivatized (SeMet) crystals full-length were obtained using the hanging-drop vapour-diffusion method. The greatly improved by adding tris(2-carboxyethyl)phosphine as reducing reagent diffracted to 3.5 Å resolution. Preliminary phase calculations data set from SeMet...
Osimertinib, a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), is effective against EGFR-mutated non-small cell lung carcinoma resistant to first- or second-generation EGFR-TKIs in patients whom an EGFR T790M mutation has been detected. Detection of the using circulating tumor DNA (ctDNA) less invasive than tissue re-biopsy, including transbronchial biopsy; however, prognostic implications ctDNA have not fully elucidated.We retrospectively reviewed...
Malignant peritoneal mesothelioma is a rare tumor with poor prognosis and has no recommended therapy after first-line pemetrexed platinum-based chemotherapy. Moreover, effects of immune checkpoint inhibitors on remains to be elucidated. We herein report the case 75-year-old man treated cisplatin plus subsequent nivolumab.A was referred our hospital due lower abdominal pain.Positron emission tomography-computed tomography (CT) showed accumulation fluorodeoxyglucose in an intraperitoneal mass....
Ageing induces functional and structural alterations in organs, age-dependent parameters have been identified various medical data sources. However, there is currently no specific clinical test to quantitatively evaluate age-related changes bronchi. This study aimed identify bronchial features using explainable artificial intelligence for bronchoscopy images.The present included 11 374 images, divided into training datasets based on the time axis. We constructed convolutional neural network...
Although there has been significant progress in immune-checkpoint inhibitor (ICI) treatment, it remains controversial whether they should be used the treatment of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). We herein report case an NSCLC patient with uncommon complex EGFR mutations (G719S and L861Q) who was refractory to afatinib but showed a good response pembrolizumab treatment. A 65-year-old female ex-smoker diagnosed right upper lobe (clinical stage...