A5026964827- Iron Metabolism and Disorders
- Lung Cancer Treatments and Mutations
- Trace Elements in Health
- Advanced Vision and Imaging
- Advanced Image Processing Techniques
- Pediatric Urology and Nephrology Studies
- Cancer Genomics and Diagnostics
- Animal health and immunology
- Infant Nutrition and Health
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Cardiac Imaging and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Image Processing Techniques and Applications
- MRI in cancer diagnosis
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Palliative Care and End-of-Life Issues
- Cardiac Valve Diseases and Treatments
Teikyo University
2017-2024
The University of Tokyo
2003-2024
Meiji University
2023
Teikyo University Hospital
2021-2023
Okayama Saiseikai General Hospital
2021
Udayana University
2021
National Cheng Kung University Hospital
2021
Nihon Medi-Physics (Japan)
2018
Mie University
2011-2017
Mitsubishi Electric (Japan)
2017
Abstract For detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis, serum α-fetoprotein has been widely used, but its sensitivity not satisfactory, especially small, well-differentiated HCC, and complementary marker clinically required. Glypican-3 (GPC3), a heparan sulfate proteoglycan anchored to the plasma membrane, is good candidate HCC because it an oncofetal protein overexpressed at both mRNA levels. In this study, we demonstrated that NH2-terminal portion...
Abstract Background and Aim: Low levels of serum adiponectin have been reported to be associated with obesity, diabetes, non‐alcoholic steatohepatitis (NASH), as well several malignancies. Adiponectin knockout (KO) mice cause insulin resistance neointimal formation the artery. We used KO fed a high fat (HF) diet, investigated effect on progression carcinogenesis in vivo . Methods: wild type (WT) were HF diet or normal chow for periods 24 48 weeks. The contained 60% calories from fat....
Comprehensive cancer genome profiling (CGP) has been nationally reimbursed in Japan since June 2019. Less than 10% of the patients have reported to undergo recommended treatment. Todai OncoPanel (TOP) is a dual DNA-RNA panel as well paired tumor-normal matched test. Two hundred underwent TOP part Advanced Medical Care B with approval from Ministry Health, Labour and Welfare between September 2018 December Tests were carried out cancers without standard treatment or when had already undergone...
We report a 69-year-old female patient with advanced lung cancer who developed myocarditis concomitant myasthenia gravis (MG), also known as "Herzmyasthenie," after 3 cycles of nivolumab administration. Her initial symptoms were general malaise and double vision. However, her deteriorated rapidly the following day, necessitating temporary pacemaker noninvasive positive pressure ventilation in intensive care unit. Immunohistochemical examination myocardial biopsy suggested an immune response...
Background:Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter – strain or rate direction of myocardial deformation longitudinal circumferential is the most useful marker LV pressure.Methods Results:We conducted a prospective multicenter study compared Doppler- STE-derived time constant decay (τ) mean...
Computed tomography of tracheopathia osteoplasticaH Onitsuka, N Hirose, K Watanabe, H Nishitani, Kawahira, Matsuura and ShigematsuAudio Available | Share
Mammary tumors are the most common tumor type in intact female dogs. Recently, breast cancer 2 early onset (BRCA2) gene was proposed to be associated with tumorigenesis The expression level of BRCA2 is important for its DNA repair function mammalian cells, and linked mammary tissue. However, canine unclear. mRNA levels were compared between seven gland samples seventeen isolated from lower than samples. We attempted identify why decreased by promoter sequencing analysis; however, we did not...
The patient was a 69-year-old male who had started experiencing acute-onset pain in both shoulder joints and edema of hands feet. His symptoms progressively worsened within 1 month. Laboratory data indicated elevated CRP erythrocyte sedimentation rate despite the normal range antinuclear antibodies rheumatoid factor organ function. Furthermore, imaging hand synovitis without bone erosions. Meanwhile, chest CT revealed lung tumor, leading to diagnosis primary adenocarcinoma with EGFR mutation...
Objective: The Fukushima Daiichi nuclear disaster in 2011 produced psychological reactions among evacuees. Despite the harsh situation, subsequently, there has been gradual progress reconstruction, with more than half of evacuees returning after evacuation. Our hypothesis is that evacuee mental health will now be better due to new stable living conditions. This study aims clarify statuses distress, post-traumatic stress, and radiation anxiety who have rebuilt permanent homes Methods: A...
Sympathetic stimulation of the Müller muscle may be responsible for most medically reversible cases eyelid retraction in patients with Graves disease. The authors studied 21 class I ophthalmopathy (GO), 32 disease without (GD), and 12 control subjects. T1-weighted spin-echo magnetic resonance (MR) imaging was performed a 0.5-T superconducting system. thickness levator palpebrae superioris determined from sagittal MR images. muscles GD did not differ subjects, but GO were significantly...
<h3>Objective</h3> To assess the impact of serum intact parathyroid hormone (PTH) levels on haemodynamic state and their relations by comparing plasma B-type natriuretic peptide (BNP) levels. <h3>Design</h3> Cross-sectional study in molecular epidemiology. <h3>Setting</h3> Mie University Hospital, Tsu, Japan. <h3>Patients</h3> Consecutive 105 patients with chronic heart failure (CHF). <h3>Main outcome measures</h3> Serum PTH BNP were assessed simultaneously right catheterisation....
The serum ferritin concentration was significantly higher in female than male rats, reflecting iron stores females males. mean iron/protein ratio of 0.018+/-0.008 (SD) (microg Fe/microg protein) rats and 0.011+/-0.011 being much lower that liver (0.233+/-0.014 0.227+/-0.020 males). Iron loading increased concentration, but did not influence the content ferritin. These results indicate rat contains only a small amount independent body stores.
Abstract Background We investigated longitudinal right ventricular (RV) function assessed using speckle-tracking strain echocardiography in patient with myocardial infarction (MI), and identified the contributing factors for RV dysfunction. Methods retrospectively studied 71 patients old MI (the OMI group) 45 normal subjects Control who underwent a transthoracic echocardiography. Global free wall peak systolic strains (PSSs) direction were measured by Left (LV) PSSs longitudinal, radial...