A5065277931- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Congenital Heart Disease Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone and Joint Diseases
- Cardiac Structural Anomalies and Repair
- HER2/EGFR in Cancer Research
- Liver Disease and Transplantation
- Infective Endocarditis Diagnosis and Management
- Metastasis and carcinoma case studies
- Pregnancy and preeclampsia studies
- Lung Cancer Research Studies
- Oral and Maxillofacial Pathology
- Hemodynamic Monitoring and Therapy
- Pharmacological Effects and Assays
- CAR-T cell therapy research
- Tumors and Oncological Cases
- Effects of Radiation Exposure
- IgG4-Related and Inflammatory Diseases
- Inflammatory Myopathies and Dermatomyositis
Ono Pharmaceutical (Japan)
1999-2024
Tottori University
2023
Teikyo University Hospital
2023
Teikyo University
2015-2022
Tottori University Hospital
2017
Tokyo Women's Medical University
1997-2008
Tokyo Women's Medical University Hospital
2005
Oji General Hospital
2005
Harvard University
2001
Aim: To assess the clinical features/imaging characteristics of pneumonitis reported during nationwide nivolumab postmarketing surveillance in Japan. Patients & methods: Clinical and radiological data were collected from cases during/after treatment for melanoma or non-small-cell lung cancer. The expert central review committee evaluated each case. Results: Among 144 analyzed, 91 (63.2%) had patterns considered typical drug-induced 53 (36.8%) patients previously unobserved with one more...
To elucidate the roles ofSHP-2, we generated transgenic (Tg) mice expressing a dominant negative mutant lacking protein tyrosine phosphatase domain (ΔPTP). On examining two lines of Tg identified by Southern blot, transgene product was expressed in skeletal muscle, liver, and adipose tissues, insulin-induced association insulin receptor substrate 1 with endogenous SHP-2 inhibited, confirming that ΔPTP has property. The intraperitoneal glucose loading test demonstrated an increase blood...
Postmarketing surveillance of Japanese patients with unresectable, previously treated, advanced or recurrent non-small-cell lung cancer treated nivolumab was undertaken during the conditional approval period. The study aim to evaluate occurrence treatment-related adverse events in real world. Patients were registered between December 2015 and March 2016 at 536 sites. Nivolumab given intravenously (3 mg/kg every 2 weeks); observation period 12 months after first dose nivolumab. evaluated for...
The patient was a 69-year-old male who had started experiencing acute-onset pain in both shoulder joints and edema of hands feet. His symptoms progressively worsened within 1 month. Laboratory data indicated elevated CRP erythrocyte sedimentation rate despite the normal range antinuclear antibodies rheumatoid factor organ function. Furthermore, imaging hand synovitis without bone erosions. Meanwhile, chest CT revealed lung tumor, leading to diagnosis primary adenocarcinoma with EGFR mutation...
The current study aims to evaluate the long-term outcomes of Konno procedure.The clinical records 63 patients who had undergone procedure between February 1984 and March 2007 were reviewed. During this period, Ross was introduced in 1996. Of patients, 38 male 25, female. Their ages at time operation ranged from 1 year 9 months 37 years, their body weights 8.1 kg. Valves larger than 23 mm used 57 patients.There one hospital death (myocardial infarction) six late deaths (sudden death, 2;...
Nivolumab, a monoclonal antibody against human programmed death 1, was approved for the treatment of melanoma in July 2014 Japan. Because Japanese phase II studies (ONO-4538-02, ONO-4538-08) enrolled small numbers patients, post-marketing surveillance (PMS; JapicCTI-163 272) conducted to collect safety data larger patient population. We report patients who received nivolumab between 4, and February 28, 2017. Data collected included baseline characteristics, laboratory tests,...
Abstract Nivolumab, a human monoclonal antibody against programmed death‐1, is approved for the treatment of non–small cell lung cancer (NSCLC). Although nivolumab generally well tolerated, it can cause interstitial disease (ILD), rare but potentially fatal immune‐related adverse event. Currently, there are limited data available on nivolumab‐induced ILD and its outcome. This retrospective cohort study based post–marketing described outcome in NSCLC patients Japan through assessment clinical...
Nivolumab can cause interstitial lung disease (ILD), which may be fatal; however, mortality risk factors have not been identified. This postmarketing study evaluated the poor prognostic of ILD in nivolumab-treated patients with non-small cell cancer (NSCLC) Japan. Clinical and chest imaging findings for each case were assessed by an expert central review committee, prognosis was radiographic findings, including presence/absence peritumoral ground-glass opacity (peritumoral-GGO). Poor...
Neutrophil-to-lymphocyte ratio (NLR) has recently attracted attention as a prognostic predictor in patients with non-small cell lung cancer (NSCLC) who receive immune checkpoint inhibitors (ICIs). However, the utility of NLR relation to cytotoxic anticancer drugs or molecular targeted remains unclear. We determined if could predict treatment efficacy and prognosis NSCLC drugs, well ICIs, cross-sectional manner.Of 658 advanced received first-line systemic our hospital between 2008 2019, 312...
Background: Central venous catheters (CVCs) are sometimes superior to peripheral vascular access for chemotherapy. line-associated bloodstream infections (CLABSIs) an important complication of CVCs in
In lung cancer, several potential mechanisms of intrinsic and acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been explored, including mesenchymal-epithelial transition (MET) signaling pathway activation. On the other hand, vascular endothelial (VEGF) production EGFR-mutated cancer cells is stimulated by predominantly activated MET pathway. Therefore, inhibition VEGF axis as downstream target seems promising. Here, for first time, we...
It has been shown that metastases to the thyroid from extrathyroidal malignancies occur as solitary or multiple nodules, may involve whole gland diffusely. However, diffuse metastasis of gastric cancer is extremely rare. Here, we report a case 74-year-old woman with infiltration adenocarcinoma (signet-ring-cell carcinoma/poorly differentiated adenocarcinoma) cells in thyroid. The pathological diagnosis was made based on upper gastrointestinal endoscopy biopsy and fine-needle aspiration...
A 50-year-old man with lung adenocarcinoma (c-T1aN2M1b) experienced reddish purpura mainly on the lower legs after receiving 12 cycles of second-line chemotherapy docetaxel. There was tumor enlargement computed tomography performed to assess therapeutic response, so paraneoplastic IgA vasculitis considered. diagnosed based a biopsy skin lesion and histology an upper gastrointestinal hemorrhagic mucosal erosion. As can lead serious or systemic complications, should be considered as...
Docetaxel monotherapy is one of the standard treatments for non-small-cell lung cancer in elderly patients. The addition bevacizumab to docetaxel seems promising; however, feasibility this combination has not been investigated such Patients with advanced non-squamous aged 70 years or older who had previously received cytotoxic chemotherapy were enrolled. Level 0 cohort 60 mg/m2 and 15 mg/kg, whereas those Level-1 50 mg/kg. Chemotherapy was repeated 3 weekly six cycles. primary endpoint...
A 40-year-old man with a diagnosis of lung adenocarcinoma (cT4N3M1c, stage IVB) experienced worsening lymphangitic carcinomatosis in the right and pleural effusion after receiving 1 cycle first-line chemotherapy consisting cisplatin pemetrexed. Bevacizumab was thus added from second cisplatin-pemetrexed regimen, leading to marked improvement pulmonary decrease effusion. Subsequently, maintenance therapy pemetrexed bevacizumab continued, successfully long-term progression-free survival....
The patient was a 66-year-old woman. An induration of approximately 15 mm in size that accompanied redness palpable the umbilical fossa. She did not respond to 1-month antibiotic treatment provided by previous physician. For this reason, biopsy site performed with possibility neoplastic disease mind, resulting detection adenocarcinoma. Subsequent detailed whole-body examination revealed advanced gastric cancer and peritoneal dissemination, fossa diagnosed as direct infiltration from...
Common dermatological side-effects associated with erlotinib, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), include pruritus and skin rash, which are mediated by substance P, leading to the occasional discontinuation of cancer treatment. Aprepitant is an antagonist neurokinin-1 receptor, through P activates pruritogens. Thus, aprepitant expected offer a promising option for treatment erlotinib-induced pruritus. However, appropriate schedule administration under...
Abstract Background Nivolumab has been approved for treating ≥ 10 cancer types. However, there is limited information on the incidence of rare, but potentially serious, treatment-related adverse events (TRAEs), as well notable TRAEs in patients with certain medical disorders or older Japan. Methods We performed pooled analyses data from published post-marketing surveillance Japan nivolumab monotherapy malignant melanoma, non-small cell lung cancer, renal carcinoma, head and neck gastric to...
A perinatal and postnatal study of landiolol hydrochloride (ONO-1101), a novel ultra short acting β-blocker, was conducted in Sprague-Dawley (SD) rats. ONO-1101 administered intravenously at dose level 0 (control), 25, 50 or 100 mg/kg/day from day 17 gestation to 20 after parturitation examine the effects on pregnancy, delivery, lactation growth development offspring. In group, hypoactivity, reddish lacrimation, clonic convulsion bradypnea/apnea were observed administration 5 animals died...