A5005087904- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Antimicrobial Peptides and Activities
- Viral gastroenteritis research and epidemiology
- Parasitic Infections and Diagnostics
- Virus-based gene therapy research
- Food Allergy and Anaphylaxis Research
- Protease and Inhibitor Mechanisms
- Travel-related health issues
- vaccines and immunoinformatics approaches
- Amoebic Infections and Treatments
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Plant Virus Research Studies
- Protist diversity and phylogeny
- Neonatal Respiratory Health Research
- Transgenic Plants and Applications
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Peptidase Inhibition and Analysis
National University of General San Martín
2012-2023
University of Pittsburgh
2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2023
Fundación Instituto Leloir
2021-2023
Allergic asthma is an inflammatory disorder characterized by infiltration of the airway wall with cells driven mostly activation Th2-lymphocytes, eosinophils and mast cells. There a link between increased allergy reduction some infections in Western countries. Epidemiological data also show that respiratory less frequent people exposed to orofecal foodborne microbes such as Toxoplasma gondii. We previously showed both acute chronic parasite T. gondii infection substantially blocked...
Abstract Brucella lumazine synthase (BLS) is a homodecameric protein that activates dendritic cells via toll like receptor 4, inducing the secretion of pro-inflammatory cytokines and chemokines. We have previously shown BLS has therapeutic effect in B16 melanoma-bearing mice only when administered at early stages tumor growth. In this work, we study mechanisms underlying BLS, by analyzing microenvironment. Administration growth induces high levels serum IFN-γ, as well an increment...
Serine-proteases are important players in the pathogenesis of asthma, promoting inflammation and tissue remodeling. It’s also known that many serine protease inhibitors display immunomodulatory properties. TgPI-1 is a Toxoplasma gondii protein exhibits broad spectrum inhibitory activity against proteases. In view increased prevalence atopic disorders need to develop new treatment strategies we sought investigate potential for treating respiratory allergies. For this purpose, developed...
Glucocorticoids are among the most effective drugs to treat asthma. However, severe adverse effects associated generate need for its therapeutic optimization. Conversely, though histamine is undoubtedly related asthma development, there a lack of efficacy antihistamines in controlling symptoms, which prevents their clinical application. We have reported that potentiate glucocorticoids' responses vitro and recent observations indicated coadministration an antihistamine synthetic...
Most approved vaccines against COVID-19 have to be administered in a prime/boost regimen. We engineered novel vaccine based on chimeric human adenovirus 5 (hAdV5) vector. The (named CoroVaxG.3) is three pillars: (i) high expression of Spike enhance its immunodominance by using potent promoter and an mRNA stabilizer; (ii) enhanced infection muscle dendritic cells replacing the fiber knob domain hAdV5 hAdV3; (iii) use stabilized prefusion conformation. transduction with CoroVaxG.3-expressing...
Abstract COVID-19 vaccines were originally designed based on the ancestral Spike protein, but immune escape of emergent Variants Concern (VOC) jeopardized their efficacy, warranting variant-proof vaccines. Here, we used preclinical rodent models to establish cross-protective and cross-neutralizing capacity adenoviral-vectored expressing VOC-matched Spike. CoroVaxG.3-D.FR, matched Delta Plus Spike, displayed highest levels nAb VOC mismatched variants. Cross-protection against viral infection...
We have previously showed rTgPI-1 tolerogenic adjuvant properties in asthma treatment, turning it a promising candidate for allergen-specific immunotherapy. This therapy is an alternative treatment to control that still presents several concerns related its formulation. contains independent inhibitory domains able inhibit trypsin and neutrophil elastase, both involved pathology.In view of the need design rational therapies, herein we investigated contribution different therapeutic...
Abstract Protists have been identified as part of the mammalian gut microbiome and are known to impact immunity complex intestinal diseases such inflammatory bowel disease (IBD). In humans, studies mainly describe host interactions with disease-causing species, while little is about how commensal protists immune system. from Parabasalid family, including Pentatrichomonas hominis (P. hominis), in 30% healthy individuals; however, role these non-pathogenic Parabasalids remains unstudied. Our...
ABSTRACT Most approved vaccines against COVID-19 have to be administered in a prime/boost regimen. We engineered novel vaccine based on chimeric hAdV5 vector. The (named CoroVaxG.3) is three pillars: i) high expression of Spike enhance its immunodominance by using potent promoter and mRNA stabilizer; ii) enhanced infection muscle dendritic cells replacing the fiber knob domain hAdV3; iii) use stabilized prefusion conformation. Transduction with CoroVaxG.3 expressing (D614G) dramatically...