A5087213894- Hair Growth and Disorders
- Skin and Cellular Biology Research
- Wnt/β-catenin signaling in development and cancer
- Veterinary Oncology Research
- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Neurological diseases and metabolism
- Autoimmune Bullous Skin Diseases
- Dermatologic Treatments and Research
- Herpesvirus Infections and Treatments
- Dermatological and Skeletal Disorders
- Allergic Rhinitis and Sensitization
- Veterinary Equine Medical Research
- T-cell and B-cell Immunology
- Polyamine Metabolism and Applications
- Food Allergy and Anaphylaxis Research
- Mast cells and histamine
- Dermatological diseases and infestations
- RNA regulation and disease
- Rabies epidemiology and control
- Veterinary Orthopedics and Neurology
- Fibroblast Growth Factor Research
- Skin Diseases and Diabetes
- Study of Mite Species
- Soft tissue tumors and treatment
Hirslanden Klinik Aarau
2013-2023
University of Bern
2005-2022
University of Göttingen
2009
University of Veterinary Medicine Hannover, Foundation
2009
University of Zurich
2009
Canine atopic dermatitis sensu stricto and food-induced allergic are common canine skin conditions, which often considered clinically undistinguishable. Several attempts have been made to describe populations of dogs determine breed predisposition but the results were biased by use hospital as control group. The present study aims a population Swiss food-allergic compare it with data set representing more than 85% all dogs. study, was carried out during 1 year in several practices teaching...
Two cats with Leishmania species infections were investigated. The first had been imported from Spain a non‐healing, ulcerated nodule on hindleg. presence of was detected by histopathology and PCR samples skin. lesion unresponsive to treatment allopurinol for three months but the cat treated successfully removing surgically. second lived in both Switzerland, history recurrent skin lesions its head neck. A diagnosis pemphigus foliaceus made basis histopathology, serology ( ELISA ) positive,...
Summary Hereditary hair length variability in mice and dogs is caused by mutations within the fibroblast growth factor 5 ( FGF5 ) gene. The aim of this study was to evaluate feline orthologue as a functional candidate gene for long phenotype cats, which recessive short hair. We amplified cDNA characterised two alternatively spliced transcripts RT‐PCR. Comparative genomic DNA sequencing long‐ short‐haired cats revealed four non‐synonymous polymorphisms coding sequence. A missense mutation...
The usual treatment of dogs with inflammatory bowel disease (IBD) consists administration immunosuppressive doses steroids. However, some are refractory to steroid and pose a significant challenge the veterinarian. Because cyclosporine A (cyA) has been shown be effective in steroid‐resistant IBD humans, purpose this study was investigate pharmacokinetics clinical efficacy PO cyA steroid‐refractory (n = 14). All were treated 5 mg/kg q24h for period 10 weeks. activity score assigned assess...
The usual treatment of dogs with inflammatory bowel disease (IBD) consists administration immunosuppressive doses steroids. However, some are refractory to steroid and pose a significant challenge the veterinarian. Because cyclosporine A (cyA) has been shown be effective in steroid-resistant IBD humans, purpose this study was investigate pharmacokinetics clinical efficacy PO cyA steroid-refractory (n = 14). All were treated 5 mg/kg q24h for period 10 weeks. activity score assigned assess...
Background – Noninflammatory alopecia is a frequent problem in dogs, and the pathogenesis still unclear. Objective The objective of this study was comparative histological description skin biopsies from dogs with different alopecic disorders control matched for coat type, season disease duration. Animals Twenty‐one cases X plush‐coated 12 recurrent flank alopecia, three hyperestrogenism, 15 hyperadrenocorticism, hypothyroidism primary unknown cause were evaluated. controls 38 types. Methods...
An innovative approach was tested to treat cat allergy in humans by vaccinating cats with Fel-CuMV (HypoCatTM), a vaccine against the major allergen Fel d 1 based on virus-like particles derived from cucumber mosaic virus (CuMV-VLPs). Upon vaccination, develop neutralizing antibodies 1, which reduces level of reactive allergen, thus lowering symptoms or even preventing allergic reactions humans. The combined methodological field study included ten cat-allergic participants who lived together...
Hereditary nasal parakeratosis (HNPK), an inherited monogenic autosomal recessive skin disorder, leads to crusts and fissures on the planum of Labrador Retrievers. We performed a genome-wide association study (GWAS) using 13 HNPK cases 23 controls. obtained single strong signal chromosome 2 (praw = 4.4×10−14). The analysis shared haplotypes among defined critical interval 1.6 Mb with 25 predicted genes. re-sequenced genome one case at 38× coverage detected 3 non-synonymous variants in...
Background Exfoliative dermatitis has been described in cats as a paraneoplastic skin disease associated with thymoma. There are anecdotal reports of cases without thymoma, various suspected aetiologies. Hypothesis/Objectives To identify common features, underlying causes, response to therapy and outcome nonthymoma‐associated exfoliative cats. Methods Retrospective analysis was carried out presented dermatology referral centres or submitted for histopathological examination. Detailed...
Abstract Canine idiopathic sebaceous adenitis (ISA) is an inflammatory reaction of glands, potentially resulting in their complete loss. It considered a T‐cell‐mediated disease, but its precise pathogenesis still unknown. Topical treatment with oil soaks, humectants and shampoos effective laborious. Ciclosporin A (CsA), immunomodulatory drug, has recently been shown to ameliorate the clinical picture ISA reduce inflammation greatly. is, however, expensive option. The objective this...
Abstract Chorioptes bovis infestation is a common cause of pastern dermatitis in the horse, with predilection draft horses and other thick hair ‘feathers’ on distal limbs. The treatment this superficial mite challenging; failure relapse are common. Furthermore, C. may affect progression chronic (also known as proliferative dermatitis, progressive lymphoedema verrucosa) horses, manifesting oedema, lichenification excessive skin folds that can progress to verruciform lesions. An effective cure...
Coat color dilution in dogs is a specific pigmentation phenotype caused by defective transport of melanosomes leading to large clumps pigment. It inherited as Mendelian autosomal recessive trait and may be accompanied hair loss, the so-called alopecia (CDA), or black follicular dysplasia (BHFD). We previously identified noncoding c.-22G>A transition melanophilin gene ( MLPH ) candidate causative mutation for dilute phenotype. have now extended our study genotyped 935 from 20 breeds...
Abstract The pathogenesis of equine urticaria is not well understood. In man, has been associated with immunological and nonimmunological mechanisms leading to the release various mediators by mast cells. Skin biopsies 32 horses a history were stained toluidine blue, double‐labelling method for chymase tryptase, immunohistochemistry immunoglobulin (Ig)E. These compared pemphigus foliaceus, insect bite hypersensitivity control healthy skin. Neither formalin fixation time nor biopsy site...
Abstract Alopecia areata is a hair loss disorder in humans, dogs and horses with suspected autoimmune aetiology targeting anagen follicles. only sporadically reported cows. Recently, we observed several cases of alopecia Eringer The aim this study was to confirm the presumptive diagnosis define clinical phenotype histopathological patterns, including characterization infiltrating inflammatory cells. Twenty cows 11 without skin problems were included study. Affected had either generalized or...
Alopecia X is a noninflammatory, progressive, bilateral symmetric alopecia in dogs. The disease mainly found Nordic breeds. breed predisposition and strong familial accumulation suggest hereditary background. We analyzed the cathepsin L2 gene (CTSL2) as candidate for X. comparative sequencing of 14 affected 18 control animals revealed ten polymorphisms; however, none these polymorphisms coding sequence. Haplotype analysis did not reveal an association one particular CTSL2 haplotype with...
Hereditary equine dermal asthenia (HERDA) is an autosomal recessive skin disease that affects predominantly Quarter Horses and related breeds. Typical symptoms are easy bruising hyperextensible on the back. The prognosis guarded, as affected horses cannot be ridden normally often euthanised. In Horse, HERDA associated with a mutation in cyclophilin B (PPIB), enzyme involved triple helix formation of collagen. Here we describe case Swiss Warmblood filly without PPIB-mutation which also could...
Background Noninflammatory alopecia is a frequent problem in dogs. Estrogen‐induced well described dogs, with estrogen producing testicular tumors and canine female hyperestrogenism. Objectives To increase awareness that extensive dogs can be caused by exposure to estradiol gel used owners treat their postmenopausal symptoms. Animals Skin biopsies from five were examined. Methods Owners asked for thorough case history, including possible an gel. Complete blood work serum chemistry panel...
Bald thigh syndrome is a common hair loss disorder in sighthounds. Numerous possible causes, including environmental conditions, trauma, stress, endocrinopathies and genetic components have been proposed, but only ruled out scientifically. The overall goal of our study was to identify the cause bald pathological changes associated with it. We approached this aim by comparing skin biopsies shafts affected control dogs microscopically as well applying high-throughput technologies such...
Domestic and wild felids are considered suitable hosts for the parasitic mite Sarcoptes scabiei, sarcoptic mange is reported in several felid species scientific literature. However, historic classification of mites into host-specific varieties does not include S. scabiei var. felis. It unclear whether transmission involves canids, other sympatric species, or exclusively felids. This study aimed to characterize genetic structure from domestic cats (Felis catus) Eurasian lynx (Lynx...
Scleromyxedema—the generalized form of lichen myxedematosus, a primary mucinosis—is rare disease in human patients. It is characterized by dermal mucin deposits, increased numbers fibroblasts, and variable fibrosis the absence thyroid disease. accompanied 80% cases monoclonal gammopathy. To date, scleromyxedema with systemic involvement has not been documented domestic animals. This first report scleromyxedema-like syndrome cat, which had substantial deposition dermis head paws mild...
Summary Objective: To describe an alternative method for the treatment of non-responsive self-mutilation injuries in three dogs after carpal/tarsal arthrodesis. Study design: Case series Animals: Two with carpal injury and one dog tarsal treated by arthrodesis Methods: All developed due to licking and/or chewing toes within 21–52 days surgery. Clinical signs did not resolve week conservative wound debridement protective bandages. Following general anaesthesia, a deep horseshoe-shaped skin...