A5059407335- Full-Duplex Wireless Communications
- Rheumatoid Arthritis Research and Therapies
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Systemic Lupus Erythematosus Research
- COVID-19 diagnosis using AI
- Helicobacter pylori-related gastroenterology studies
- Antenna Design and Analysis
- Neonatal Respiratory Health Research
- Viral Infections and Immunology Research
- Hepatitis C virus research
- RNA Research and Splicing
- HIV Research and Treatment
- Cystic Fibrosis Research Advances
- Genomic variations and chromosomal abnormalities
- Pharmacological Effects of Natural Compounds
- HIV/AIDS drug development and treatment
- RNA Interference and Gene Delivery
- Pharmacological Effects and Assays
- Spondyloarthritis Studies and Treatments
University of Sassari
1991-2024
Azienda Ospedaliero Universitaria di Sassari
2021-2022
Temple University
2017
The human endogenous retrovirus (HERV)-K, mouse mammary tumor virus like-2 (HML-2) subgroup of HERVs is activated in several tumors and has been related to prostate cancer progression motor neuron diseases. cellular splicing factor 2/alternative (SF2/ASF) a positive regulator gene expression, coded by potent proto-oncogene, amplified, abnormally expressed tumors. TAR DNA-binding protein-43 (TDP-43) DNA/RNA-binding protein, negative alternative splicing, known for causing neurodegeneration,...
Colorectal cancer (CRC) ranks as the most frequent carcinoma worldwide. CRC patients show strong prognostic differences and responses to treatment, 20% have incurable metastatic disease at diagnosis. We considered it essential investigate mechanisms that control cellular regulatory networks, such miRNA-mRNA interaction, known be involved in pathogenesis. conducted a human miRNome analysis by TaqMan low density array, comparing normal colon tissue (NCT, experimentally identified gene targets...
Colorectal cancer (CRC) is a leading cause of death worldwide and about 20% metastatic at diagnosis untreatable. The anti-EGFR therapy in patients led by the presence KRAS-mutations tumor tissue. KRAS-wild-type CRC showed positive response rate 70% to cetuximab or panitumumab combined with chemotherapy. MiRNAs are promising markers oncology could improve our knowledge on pathogenesis drug resistance patients. This class molecules represents an opportunity for development miRNA-based...
Colorectal cancer (CRC) is the third most frequent worldwide and second cause of deaths. Increasing evidences supports idea that poor prognosis patients related to presence stem cells (CSCs), a cell population able drive recurrence metastasis. The deregulation microRNAs (miRNAs) plays role in formation CSC. We investigated hsa-miR-486-5p (miR-486-5p) CRC, CSCs, metastasis, order reach better understanding biomolecular epigenetic mechanisms mir-486-5p-related. expression miR-486-5p was three...
Next-generation sequencing (NGS) is gradually replacing Sanger for HIV genotypic drug resistance testing (GRT). This work evaluated the concordance among different NGS-GRT interpretation tools in a real-life setting.
The angiographic appearance of the coronary arteries during successful thrombolysis with urokinase was determined in 35 patients acute myocardial infarction. lysing process passed through several phases: (a) total occlusion a convex or irregular distal margin (phase 0); (b) increasing patency lumen 1); (c) re-establishment flow but intraluminal filling defects and delayed possibly due to microemboli 2); (d) partial complete disappearance 3); (e) further widening which eventually attains...
The spread of new SARS-CoV-2 variants represents a serious threat worldwide, thus rapid and cost-effective methods are required for their identification. Since November 2020, the TaqPath COVID-19 assay (Thermo Fisher Scientific) has been used to identify viral strains lineage B.1.1.7, since it fails detect S-gene with ∆69/70 deletion. Here, we proposed mutations screening Allplex (Seegene), another widely RT-PCR test that targets Sarbecovirus E, N, RdRp/S genes. Accordingly, evaluated S gene...
The JC polyomavirus (JCV) has been repeatedly but discordantly detected in healthy colonic mucosa, adenomatous polyps, and colorectal cancer (CRC), proposed to contribute oncogenesis. controversies may derive from differences JCV targets, patient’s cohorts, methods. Studies of simultaneous detection, quantification, characterization presence/expression paired samples normal/altered tissues the same patient are lacking. Therefore, we simultaneously quantified presence (DNA) expression (mRNA...
Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA. This activates DNA response (DDR) signaling including induction expression repair factor Rad51. We previously reported that Rad51 co-operates with transcription NF-κB p65 activate JCV early transcription. Thus infection may provide positive feedback for viral activation in infection. DDR...
In December 2019, a novel coronavirus emerged in Wuhan, China, rapidly spreading into global pandemic. Italy was the first European country to experience SARS-CoV-2 epidemic, and one of most severely affected during wave diffusion. contrast general restriction people movements Europe, number migrants arriving at Italian borders via Mediterranean Sea route summer 2020 had increased dramatically, representing possible, uncontrolled source for introduction variants. Importantly, came from...
A COVID-19 outbreak occurred at the end of October 2021 among pilgrims returning from Medjugorje (Bosnia and Herzegovina). Whole genome sequencing (WGS) SARS-CoV-2, epidemiological data, phylogenetic analysis were used to reconstruct dynamics. The results suggest that only in one case, associated with SARS-CoV-2 sub-lineage AY.9.2, it is possible trace back place contagion Medjugorje, while other cases likely be acquired country origin. combined use data derived WGS, allowed us study...