A5030355811- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Advanced Photonic Communication Systems
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Optical Network Technologies
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Material Dynamics and Properties
- COVID-19 diagnosis using AI
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Metallic Glasses and Amorphous Alloys
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
Changchun University of Technology
2023-2024
Second Affiliated Hospital of Fujian Medical University
2023-2024
Hangzhou First People's Hospital
2018-2024
Renmin Hospital of Wuhan University
2020-2024
Wuhan University
2020-2024
Fujian Medical University
2023-2024
Westlake University
2024
Zhejiang University
2013-2022
Nanjing Medical University
2016-2022
Blood Center of Zhejiang Province
2021-2022
Liver cancer has a high mortality and morbidity rate throughout the world. In clinical practice, prognosis of liver patients is poor, complex reasons contribute to treatment failures, including fibrosis, hepatitis viral infection, drug resistance metastasis. Thus, screening novel prognostic biomarkers great importance for guiding therapy. Orosomucoid genes (
Liver fibrosis is a chronic liver disease that could further develop to cirrhosis and carcinoma. Hepatic stellate cells (HSCs) are primary effector initiate fibrosis. We aimed explore the function underlying mechanisms of mitochondrial fusion protein Mitofusin-2 (MFN2) in First, we utilized an alpha-smooth muscle actin promoter overexpress MFN2 specifically HSCs using adeno-associated virus (AAV) vector (AAV-MFN2). Overexpression was achieved HSC-T6 cells, but not murine bone marrow-derived...
The PD-L1 protein on extracellular vesicles (EVs) is a promising biomarker for tumor immunotherapy. However,
To investigate the role of complement 5a (C5a)/C5a receptor (C5aR) pathway in pathogenesis acute liver failure (ALF) a mouse model.BALB/c mice were randomly assigned to different groups, and intraperitoneal injections lipopolysaccharide (LPS)/D-galactosamine (D-GalN) (600 mg/kg 10 μg/kg) used induce ALF. The Kaplan-Meier method was for survival analysis. Serum alanine aminotransferase (ALT) levels, at time points within 1-wk period, detected with biochemistry analyzer. Pathological...
Tumor-derived extracellular vesicles (T-EVs) hold great promise for understanding cancer biology and improving diagnostics therapeutics. Herein, we developed multivalent DNA flowers (DFs) containing repeated equidistant EpCAM aptamers the efficient isolation of T-EVs. The aptamer chains in DFs had good flexibility to adapt surface morphology T-EVs achieved ligand–receptor interactions, thus showing enhanced ability compared monovalent aptamers. Compared with other materials EVs, were...
Abstract Toxoplasma gondii is an opportunistic parasite with avirulent cystogenic and highly virulent non-cystogenic isolates. Although strains are considered the most virulent, there also marked genetic virulence differences among these strains. Excretory-secretory antigens (ESAs) of T. critical for invasion process immune response host. To better understand in between isolates, we studied ESAs RH strain (Type I), very prevalent China, but less TgCtwh3 (Chinese 1). triggered different...
Gastric varices (GV) with spontaneous portosystemic shunt (SPSS) are associated ectopic embolism in endoscopic cyanoacrylate. This study targeted to assess the efficacy and safety of EUS-guided coil embolization combined cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration (BRTO) for GV high-risk embolism.We retrospectively analyzed six tertiary hospitals' 104 patients at (the narrowest diameter SPSS was greater than or equal 5 mm maximum usually >8 mm) who...
The cause of some patients with negative RT-PCR results experienced turn-positive after treatment remains unclear. In addition, understanding the correlation between changes in clinical data course COVID-19 and outcomes is great importance determining prognosis COVID-19. To perform analysis effective screening factors related to outcome Clinical data, including manifestations, laboratory tests, radiography results, methods outcomes, were retrospectively collected analyzed from January March...
In this work, we present a method for optical frequency multiplication utilizing hybrid deep learning approach that integrates the Residual Network (ResNet) with Random Forest Regression (RFR) algorithm. Three different modulation schemes are adopted to illustrate method, which can obtain suitable parameters these schemes. Based on predicted by algorithm, 8-tupling, 12-tupling, and 16-tupling mm-wave signals generated numerical simulation. The simulation results show 8-tupling...
Abstract Extracellular vesicles (EVs) have demonstrated significant potential in drug delivery and anti‐tumor therapy. Despite this promising strategy, challenges such as specific targeting, EVs purification persist. In study, a personalized nanodrug platform using patient‐derived tumor (PT‐EVs) based on microchip is presented. The integrates multiple functions, including capture, enrichment, loading, elution of PT‐EVs. isolation drug‐carrying procedures are completed within 12 h timeframe,...
Estradiol (E2) plays a crucial and intricate role during pregnancy to mediate several aspects of the process. A perplexing phenomenon in congenital toxoplasmosis is that severity Toxoplasma gondii (T. gondii)-mediated adverse outcome closely related with time primary maternal infection pregnancy. In this study, results showed T. early was more likely induce miscarriage mice than late pregnancy, which may be inflammation maternal-fetal interface. Meanwhile, induced-apoptotic rate Tregs higher...
BACKGROUNDThe first line treatment regimen for esophageal cancer is still surgical resection and the choice of scheme depends on surgeon.Now efficacy comparison hybrid minimally invasive esophagectomy (HMIE) open (OE) controversial. AIMTo compare perioperative postoperative outcomes HMIE OE in patients with cancer. METHODSPubMed, EMBASE, Cochrane Library databases were searched related articles.The odds ratio (OR) or standard mean difference (SMD) a 95% confidence interval (CI) was used to...
Abstract Strategies to sensitize hepatocellular carcinomas (HCC) programmed death-1 (PD1)/programmed death-ligand 1 (PD-L1) inhibitor therapies are important in improving the survival of HCC patients. The aim study was characterize C-X-C chemokine receptor 2 (Cxcr2) as a therapeutic target and evaluate effects Cxcr2 suppression sensitizing PD1/PD-L1 therapies. To this end, we constructed Cxcr2-knockout cell line (Hepa1-6 KO) using CRISPR-Cas9 approach assessed tumor growth rate mice after...
Abstract Background The present study aims to develop a nanoparticle encapsulating doxorubicin (DOX) and programmed death-ligand 1 (PD-L1) siRNA evaluate its anti-tumor effects on hepatoma carcinoma (HCC). Methods Nanoparticle DOX PD-L1 (NP DOX/siPD-L1 ) was characterized by dynamic light scattering transmission electron microscopy. Flow cytometry applied analyze cell populations, NP internalization, apoptosis. Real-Time (RT)-quantitative reverse transcription (qPCR) western blotting were...
This study aimed to analyze the relative expression of Eukaryotic Translation Initiation Factor 3 Subunit B (EIF3B) in pancreatic cancer and elucidate its contribution this disease.Relative EIF3B was analyzed by immunohistochemistry. Cell viability determined MTT assay cell proliferation measured direct counting. apoptosis detected Annexin V staining followed flow cytometry analysis, cycle PI staining. The differential gene analysis performed microarray. Tumor progression response deficiency...
Pancreatic cancer is one of the most lethal malignant tumors. However, molecular mechanisms responsible for its progression are little known. This study aimed to understand regulatory role CD44V3 in pancreatic cancer. A Kaplan-Meier analysis was performed reveal correlation between CD44/CD44V3 expression and prognosis patients. U2AF1 were knocked down using shRNAs. The proliferation, migration, invasion, stemness two cell lines, BxPC-3 AsPC-1, examined. CD44V3, cancer-associated markers,...