A5067097789- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
- Advanced Chemical Sensor Technologies
- Chemokine receptors and signaling
- Estrogen and related hormone effects
- Career Development and Diversity
- Visual perception and processing mechanisms
- Dietary Effects on Health
- Biomedical and Engineering Education
- Neuroscience and Neuropharmacology Research
- Evolutionary Psychology and Human Behavior
- Olfactory and Sensory Function Studies
- Antioxidant Activity and Oxidative Stress
- Skin Protection and Aging
- Primate Behavior and Ecology
- Biochemical Analysis and Sensing Techniques
VA Puget Sound Health Care System
2020-2024
University of Massachusetts Amherst
2021-2022
The University of Texas Southwestern Medical Center
2020
Southwestern Medical Center
2020
Allen Institute
2018-2019
Allen Institute for Brain Science
2018-2019
Summary To understand how the brain processes sensory information to guide behavior, we must know stimulus representations are transformed throughout visual cortex. Here report an open, large-scale physiological survey of neural activity in awake mouse cortex: Allen Brain Observatory Visual Coding dataset. This publicly available dataset includes cortical from nearly 60,000 neurons collected 6 areas, 4 layers, and 12 transgenic lines 221 adult mice, response a systematic set stimuli. Using...
Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently demonstrated hindbrain (fourth ventricular [4V]) OT elicits loss elevates interscapular brown adipose tissue temperature (T IBAT , a surrogate measure increased EE) DIO mice. What remains unclear is whether OT-elicited requires sympathetic nervous system (SNS) outflow to IBAT....
Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing expenditure (EE). Previous our lab have shown OT into the fourth ventricle (4V; hindbrain) elicits loss stimulates interscapular brown adipose tissue temperature (TIBAT) DIO rats. We hypothesized OT-elicited stimulation sympathetic nervous system (SNS) activation IBAT contributes to its ability activate BAT reduce...
Previous studies indicate that oxytocin (OT) administration reduces body weight in high-fat diet (HFD)-induced obese (DIO) rodents through both reductions food intake and increases energy expenditure. We recently demonstrated chronic hindbrain [fourth ventricular (4V)] infusions of OT evoke loss DIO rats. Based on these findings, we hypothesized 4V would elicit mice. assessed the effects (16 nmol/day) or vehicle over 28 days weight, intake, composition. reduced by approximately 4.5% ± 1.4%...
Previous studies have indicated that oxytocin (OT) reduces body weight in diet-induced obese (DIO) rodents through reductions energy intake and increases expenditure. We recently demonstrated hindbrain [fourth ventricular (4V)] administration of OT evokes loss elevates interscapular brown adipose tissue temperature (T IBAT ) DIO rats. What remains unclear is whether can be used as an adjunct with other drugs directly target beta-3 receptors to promote BAT thermogenesis reduce hypothesized...
Abstract Age‐related cognitive decline has been extensively studied in humans, but the majority of research designs are cross‐sectional and compare across younger older adults. Longitudinal studies necessary to capture variability aging trajectories difficult carry out humans long‐lived nonhuman primates. Marmosets an ideal primate model for neurocognitive as their naturally short lifespan facilitates longitudinal designs. In a study marmosets tested on reversal learning starting middle‐age,...
Existing studies show that CNS oxytocin (OT) signaling is important in the control of energy balance, but it unclear which neurons may contribute to these effects. Our goals were examine (1) dose-response effects acute OT administration into third (3V; forebrain) and fourth (4V; hindbrain) ventricles assess sensitivity forebrain hindbrain sites, (2) extent chronic 4V reduces weight gain associated with progression diet-induced obesity, (3) whether nucleus tractus solitarius (NTS)...
Olfactory dysfunction has been identified as an early biomarker for dementia risk but rarely assessed in nonhuman primate models of human aging. To better characterize common marmosets such models, we olfactory discrimination performance a sample 10 animals (5 females), aged 2.5-8.9 years old. The monkeys were proficient the and reversal visual stimuli naïve to odor stimuli. For discrimination, performed series six discriminations increasing difficulty between two We found no evidence...
Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently demonstrated hindbrain (fourth ventricular [4V]) OT elicits loss elevates interscapular brown adipose tissue temperature (T
Abstract Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing expenditure (EE). Previous our lab have shown OT into the fourth ventricle (4V; hindbrain) elicits loss stimulates interscapular brown adipose tissue temperature (T IBAT ) DIO rats. We hypothesized OT-elicited stimulation sympathetic nervous system (SNS) activation contributes to its ability activate BAT...
Previous studies have indicated that oxytocin (OXT) reduces body weight in high fat diet (HFD)‐induced obese (DIO) rodents, nonhuman primates and humans through reductions energy intake increases expenditure. Recent findings support a role for brown adipose tissue (BAT) thermogenesis OXT‐elicited loss as chronic administration 1) interscapular (IBAT) temperature (T IBAT ) DIO rats during period coincides with the OXT’s initial weight‐lowering effect 2) upregulates beta‐3 receptor mRNA...
Previous studies indicate that oxytocin (OXT) reduces body weight (BW) in high fat diet (HFD)‐induced obese (DIO) rodents through mechanisms may involve an enhanced ability of OXT to reduce food intake as well increase energy expenditure. We have previously demonstrated chronic fourth ventricular (4V) infusions (as a strategy target hindbrain receptors) evokes loss DIO rats. Based on these findings, we hypothesized increased signaling would elicit BW mice maintained HFD (60% kcal from fat)....
Previous studies indicate that oxytocin (OT) administration reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently demonstrated hindbrain (fourth ventricular; 4V) of OT elicits loss elevates interscapular brown adipose tissue temperature (TIBAT; surrogate marker increased EE) DIO mice. What remains unclear is whether OT-elicited requires sympathetic nervous system (SNS) outflow to IBAT. hypothesized...
Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently demonstrated hindbrain [fourth ventricular (4V)] OT elicits loss elevates interscapular brown adipose tissue temperature (TIBAT; surrogate marker increased EE) DIO rats. What remains unclear is whether OT-elicited requires sympathetic nervous system (SNS) outflow to IBAT. hypothesized...