A5102788373- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Neurological disorders and treatments
- Insect behavior and control techniques
- PARP inhibition in cancer therapy
- Restless Legs Syndrome Research
- Advanced Breast Cancer Therapies
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
- Neutropenia and Cancer Infections
- DNA Repair Mechanisms
- Insect Utilization and Effects
- Genetic Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Cardiac Imaging and Diagnostics
- Alcoholism and Thiamine Deficiency
- Child Nutrition and Feeding Issues
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
Higashi Nagoya National Hospital
2017-2025
Kumamoto University
2017
Longitudinal studies investigating cognitive function changes in patients with progressive supranuclear palsy (PSP) are limited. The variability of impairment across clinical subtypes PSP remains unclear. This study aimed to compare the longitudinal between and Parkinson's disease (PD) assess differences among subtypes. A retrospective observational was conducted using neuropsychological testing data from PD admitted our hospital. included 38 41 (23 PSP-Richardson's syndrome, 14...
Tremor is a cardinal symptom of Parkinson's disease (PD) that occurs throughout the course in approximately 80% patients. Re-emergent tremor characterized as resting recurs after variable delay during postural maintenance.1 It usually observed extremities and rarely speech-related organs, such tongue jaw.2, 3 To our knowledge, no studies have reported on re-emergent tremors involving voice. A 71-year-old woman developed her was diagnosed with tremor-predominant PD. Levodopa effective for...
Several genetic factors are associated with the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) and its phenotypes, such as disease progression. Here, in this study, we aimed to identify genes that affect survival patients ALS.We enrolled 1076 Japanese ALS imputed genotype data 7 908 526 variants. We used Cox proportional hazards regression analysis an additive model adjusted for sex, age at onset first two principal components calculated from genotyped conduct a genome-wide...
Starvation reduces sleep in various animal species including humans and fruit flies. Immediate hunger the following insufficient nutritional status resulting from starvation may affect arousal differently. In order to clarify mechanism underlying relationship between diet sleep, we analysed behaviour of Drosophila melanogaster that were either starved or fed with different types sugars. Starved flies showed longer activity bouts, short bouts a decreased threshold. Non-nutritive sweeteners...
Both Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative disorder affecting striatonigral system. Although various lines of evidence demonstrate that dopaminergic neuron degeneration emerges before the onset motor symptoms in PD, preclinical/prodromal progression neurodegeneration is far less understood MSA.The aim this study was to clarify difference MSA PD using dopamine transporter single-photon emission computed tomography (DAT SPECT).We analyzed longitudinal...
An 83-year-old Japanese man presented with gait disturbance followed by rapidly-progressive cognitive impairment. Magnetic resonance diffusion-weighted images showed extensive hyperintense regions in the cerebral cortex. Four weeks after symptom onset, myoclonus appeared, and patient developed difficulty swallowing; intravenous peripheral continuous infusions without vitamin supplementation were administered during last two months of patient's life. The reached akinetic mutism state died 12...
Abstract Background: This study was undertaken to investigate the utility of 123 I-ioflupane ( I-FP-CIT) single photon emission computed tomography (SPECT), I-metaiodobenzylguanidine I-MIBG) scintigraphy and both these differentiate among progressive supranuclear palsy (PSP), including typical cases other subtypes, Parkinson’s disease (PD). Methods: Twenty-five patients with PSP (Richardson's syndrome; PSP-RS), 14 atypical ones (PSP-variants; PSP-V) 42 PD who underwent 23 I-FP-CIT SPECT...