A5000664745- Microbial Natural Products and Biosynthesis
- Probiotics and Fermented Foods
- Gut microbiota and health
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Clostridium difficile and Clostridium perfringens research
- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- Pediatric health and respiratory diseases
- Plant-Microbe Interactions and Immunity
- Enzyme Structure and Function
- Liver Disease Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- Animal Genetics and Reproduction
- Fungal Biology and Applications
- Genetics and Physical Performance
- Microbial Metabolites in Food Biotechnology
- Carbohydrate Chemistry and Synthesis
- Diet and metabolism studies
- Motivation and Self-Concept in Sports
- Healthcare and Venom Research
- Steroid Chemistry and Biochemistry
- Gastroesophageal reflux and treatments
- Antibiotic Resistance in Bacteria
- Genomics, phytochemicals, and oxidative stress
Chong Kun Dang Bio (South Korea)
2008-2025
Woosuk University
2023
Hungarian University of Sports Science
2023
Korea University
2019-2021
The gut microbiota plays a pivotal role in metabolic disorders, notably type 2 diabetes mellitus (T2DM). In this study, we investigated the synergistic potential of combining effects Bifidobacterium longum NBM7–1 (CKD1) with anti-diabetic medicines, LobeglitazoneⓇ (LO), SitagliptinⓇ (SI), and MetforminⓇ (Met), to alleviate hyperglycemia diabetic mouse model. CKD1 effectively mitigated insulin resistance, hepatic steatosis, enhanced pancreatic β-cell function, as well fortifying gut-tight...
ABSTRACT The full genome sequence of Clostridium botulinum type A strain X58540 found in fecal samples from cattle exhibiting clinical symptoms chronic botulism is presented here. consists 2,371,631 bp with a GC content 28.17% and predicted to include 2,157 coding sequences.
Clavulanic acid (CA) produced by Streptomyces clavuligerus is a clinically important β-lactamase inhibitor. It known that glycerol utilization can significantly improve cell growth and CA production of S. clavuligerus. We found the industrial CA-producing strain OR generated random mutagenesis consumes less than wild-type strain; we then developed mutant in which operon overexpressed, as compared to parent strain, through iterative reporter-guided selection. The resulting ORUN was increased...
The increased global prevalence of chronic respiratory diseases in recent years has caused a substantial public health burden. Lactiplantibacillus plantarum KC3 and Leonurus japonicus Houtt. (LJH) extracts can alleviate symptoms improve lung function vitro vivo. However, the clinical efficacy safety profile this combination patients with remain unclear. Therefore, multicenter, randomized, double-blind, placebo-controlled trial aimed to evaluate L. LJH adults discomfort. This mixture was...
Abstract Probiotics have been shown to provide health benefits for several metabolic diseases, including obesity, type 2 diabetes, and dysfunction-associated steatotic liver disease (MASLD), by modulating the gut microbiota. In this study, we evaluated safety efficacy of Lactobacillus delbrueckii subsp. lactis CKDB001 as a potential therapeutic candidate treatment MASLD. We antibiotic resistance, hemolytic, gelatinase, bile salt hydrolase activities, production biogenic amines D-lactate...
Background/Objectives: Functional probiotics, particularly Lactobacillus delbrueckii subsp. lactis CKDB001, have shown potential as a therapeutic option for metabolic dysfunction-associated steatotic liver disease (MASLD). However, their effects not been confirmed in vivo systems. Here, we investigated the of L. CKDB001 on insulin resistance, dyslipidemia, MASLD, and lipid metabolism murine model high-fat diet (HFD)-induced obesity. Methods: The mice were divided into four groups (n = 12 per...
To develop a strategy for improved production of clavulanic acid (CA), we investigated the effect using oils on cell growth and CA during fermentation Streptomyces clavuligerus NRRL 3585. In this analysis, triolein, whose fatty is oleic only, was best oil source production, but free acids generated from hydrolysis in culture broth negatively impacted growth. Hence, screened mutants that were resistant to high concentrations acid. From screen identified mutant S. clavuligerus, OL13, had...
A cryopreservation condition for d-amino acid oxidase (DAAO)-overexpressing Escherichia coli (E. BL21(DE3)/pET-DAAO) was established. Ten percent the optimum concentration of glycerol as a cryoprotectant, and its diffusion into stationary phase cells superior to that log cells. The results also showed rather than fast cooling, slow cooling method appropriate our recombinant E. coli. In addition, 15 min best equilibration period, at which higher 90% recovery rates were maintained all test...
Air pollutants, such as particulate matter (PM) and diesel exhaust particles (DEP), are associated with respiratory diseases. Therefore, preventive therapeutic strategies against PM-and DEP (PM
Abstract Streptomyces clavuligerus NRRL 3585 is a native producer of clavulanic acid (CA), clinically used β-lactamase inhibitor, and widely as an industrial strain for the production antibiotics. Selective random mutagenesis has successfully generated improved CA-producing S. mutant strains well with loss CA biosynthesis. To understand molecular mechanisms associated CA-production potential, genome-scale RNA-sequencing-based transcriptional data were obtained wild-type its three strains....
The purpose of this study is to compare and analyze the physical self-concept athletes general education students.For purpose, results two-way variance analysis after Korean Version PSDQ test are as follows.First, difference in according gender showed statistical significance two factors: health (p=.039*) muscle strength (p=.003**).It was consistent with research result that male students higher factor than female students.Second.The between University sports competence activity...
This study aimed to provide a neck exercise program patients in an office work environment who visit orthopedic clinic with pain and determine its effectiveness.To gather data, deep flexor strengthening thoracic spine movement were performed for ache eight weeks.Research 24 women aged 25 45 years.Based on the design, subjects split into three groups.Eight control group (CG), training (DG), doing flexion together (DTG).Each weeks, it times week 50 minutes each. this set as independent...
Probiotic strain is known to regulate the immune system by colonizing in intestine and interact with intestinal cell receptors of lymphoid tissue. In this study, safety Streptococcus thermophilus KCTC14471BP silk fibroin coating effects was evaluated respect mucin binding abilities modulation. S. coated adding 1% water-soluble calcium 0.1% fibroin. showed high activities leucine arylamidase β-galactosidase. Regarding antibiotic resistance tests, susceptible ampicillin, vancomycin,...