A5089197953- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Bone fractures and treatments
- Ultrasound and Cavitation Phenomena
- Vagus Nerve Stimulation Research
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound Imaging and Elastography
- Cervical and Thoracic Myelopathy
- Cardiovascular Health and Disease Prevention
- Microfluidic and Bio-sensing Technologies
- Neuroscience and Neural Engineering
- Hip and Femur Fractures
- Spine and Intervertebral Disc Pathology
- Neurological disorders and treatments
- Orthopaedic implants and arthroplasty
- Microbial Inactivation Methods
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Medical Imaging and Analysis
- Coronary Interventions and Diagnostics
- Molecular Communication and Nanonetworks
- Total Knee Arthroplasty Outcomes
- Berberine and alkaloids research
- Cardiovascular Health and Risk Factors
- Ferroptosis and cancer prognosis
Guangxi Medical University
2025
Dongguan University of Technology
2022-2024
Jiangsu University
2020-2024
Changchun University of Chinese Medicine
2024
Shenzhen Institutes of Advanced Technology
2016-2023
Chinese Academy of Sciences
2016-2021
First Affiliated Hospital of Soochow University
2018-2021
Soochow University
2018-2021
Shanghai Center for Brain Science and Brain-Inspired Technology
2021
Laboratoire d’Imagerie Biomédicale
2020
Abstract Background Epilepsy is a widespread and chronic disease of the central nervous system caused by variety factors. Mitochondrial ferritin (FtMt) refers to located within mitochondria that may protect neurons against oxidative stress binding excess free iron ions in cytoplasm. However, potential role FtMt epilepsy remains unclear. We aimed investigate whether its related mechanisms can regulate modulating ferroptosis. Methods Three weeks after injection adeno‐associated virus (AAV)...
Modulating basal ganglia circuitry is of great significance in the improvement motor function Parkinson’s disease (PD). Here, for first time, we demonstrate that noninvasive ultrasound deep brain stimulation (UDBS) subthalamic nucleus (STN) or globus pallidus (GP) improves behavior a subacute mouse model PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Immunohistochemical c-Fos protein expression confirms there relatively high level STN-UDBS and GP-UDBS group compared with...
Non-invasive low-intensity pulsed ultrasound has been employed for direct neuro-modulation. However, its range and effectiveness different neurological disorders have not fully elucidated. Methods: We used multiple approaches of electrophysiology, immunohistochemistry, behavioral tests as potential epilepsy treatments in non-human primate model human epileptic tissues. Low-intensity with a frequency 750 kHz acoustic pressure 0.35 MPa (the spatial peak pulse average intensity, ISPPA = 2.02...
Ultrasound stimulation has recently emerged as a non-invasive method for modulating brain activity in animal and human studies with healthy subjects. Whether diseases such Alzheimer's disease, epilepsy, depression can be treated using ultrasound still needs to explored. Recent have reported that suppressed epileptic seizures rodent model of epilepsy. These findings raise the crucial question whether inhibit non-human primates Here, we addressed this critical question. We confirmed...
Plasticity of synaptic structure and function play an essential role in neuronal development, cognitive functions, degenerative diseases. Recently, low-intensity pulsed ultrasound (LIPUS) stimulation has been reported as a promising technology for neuromodulation. However, the effect LIPUS on structural functional plasticity rat hippocampus not yet addressed. The aim this study was to investigate whether could affect dendritic structure, electrophysiological properties, expression level...
Abstract Ultrasound stimulation, as a novel and noninvasive technique for neuromodulation, shows great potential in the treatment of functional brain diseases. However, bulk volume commercial ultrasound transducers is not compatible with classical electrophysiological technique. Thus, it difficult to study biophysical transduction mechanism at single cell level using patch clamp. In this study, miniaturized neurostimulation chip developed investigate ultrasonic effects on ion channels...
Potassium ion channels (K+) play an important role in the regulation of cellular signaling. Imbalance potassium is associated with several severe diseases, such as long QT syndrome, episodic ataxia and epilepsy. Ultrasound stimulation has proven to be effective noninvasive tool modulation neural activity. In this study, we demonstrate that ultrasound enables modulate currents impact on shape action potentials (AP) hippocampal pyramidal neurons using whole-cell patch-clamp recordings vitro....
Evidence in animals suggests that deep brain stimulation or optogenetics can be used for recovery from disorders of consciousness (DOC). However, these treatments require invasive procedures. This report presents a noninvasive strategy to stimulate central nervous system neurons selectively DOC mice. Through the delivery ultrasound energy ventral tegmental area, mice were aroused an unconscious, anaesthetized state this study, and process was controlled by adjusting parameters. The sham...
The purpose of this study is to compare the stress and stability plate-screw fixation screw in treatment Schatzker type IV medial tibial plateau fracture. A three-dimensional (3D) finite element model fracture (Schatzker fracture) was created. An axial force 2500 N with a distribution 60 % compartment applied simulate compressive load on an adult knee during single-limb stance. equivalent von Mises stress, displacement relative distal tibia, implants were used as output measures. mean value...
Cell lysis is a process of breaking cell membranes to release intracellular substances such as DNA, RNA, protein, or organelles from cell. The detection protein the lysed cells importance for cancer diagnostics and drug screening. In this study, we develop microbubble array that enables realization multiple induced by shear stress resulting individual oscillating microbubbles. microbubbles in channel have similar vibration amplitudes, can be released efficiently. Moreover, efficiency...
Proximal tibia fractures are one of the most familiar fractures. Surgical approaches usually needed for anatomical reduction. However, no single treatment method has been widely established as standard care. Our present study aims to compare stress and stability intramedullary nails (IMN) fixation double locking plate (DLP) in extra-articular proximal tibial A three-dimensional (3D) finite element model fracture, whose 2-cm bone gap began 7 cm from plateau articular surface, was created...
The hypothalamus plays an important role in the control of aging. Transcranial ultrasound stimulation (TUS) has been reported as a noninvasive method neuromodulation. However, effect TUS on aging remains unclear. Therefore, aim this study is to verify whether could affect behaviors mice and expression level apoptosis factors inflammatory cytokines. was delivered ( n = 44 ) for 14 days (15 min/day) at fundamental frequency 1 MHz, pulse repetition kHz (US1) or 10 Hz (US2), duty cycle 10%,...
Preliminary evidence suggests that low-intensity pulsed ultrasound (LIPUS) has neuroprotective effects on ischemic stroke, depression, and other conditions leading to neuronal cell death (e.g., Parkinson's disease). The purpose of this study was investigate the LIPUS in epileptic mice. Mice were made through kainic acid (KA) administration then stimulated with LIPUS. effect evaluated by observing latency, anxiety-like behavior, levels proteins related inflammation, apoptosis, or signaling...
A microfluidic device based on a pair of slant-finger interdigital transducers (SFITs) is developed to achieve selective and flexible manipulation microbubbles (MBs) by surface acoustic waves (SAWs). The resonance frequency SAWs generated the SFITs depends location its parallel pathway; particles at different locations SAWs' pathway can be controlled selectively choosing excitation signal applied SFITs. By adjusting input continuously, MBs transported along aperture precisely. displacement...
Anechoic carotid plaques on sonography have been used to predict future cardiovascular or cerebrovascular events. The purpose of this study was investigate whether plaque echogenicity could be assessed objectively by combining texture features extracted MaZda software (Institute Electronics, Technical University Lodz, Poland) and morphologic characteristics, which may provide a promising method for early prediction acute disease.A total 268 images were collected from 136 volunteers...
Background: The preoperative diagnosis of phyllodes tumors (PTs) the breast is critical to appropriate surgical treatment. However, reliable differentiation between PT and fibroadenoma (FA) remains difficult in daily clinical practice. purpose this study was investigate utility MRI texture analysis for differentiating PTs from FAs. Materials Methods: Forty-two 42 FAs were enrolled retrospective study. Clinical conventional features (CCMF) used distinguish FA. Texture extracted axial short TI...
Focused ultrasound (FUS) is a potential tool for treating chronic pain by modulating the central nervous system. Herein, we aimed to determine whether transcranial FUS stimulation of anterior cingulate cortex (ACC) effectively improved in compress injury mice model at different stages neuropathic pain. The mechanical threshold was recorded nociceptive tests. We found elevated both short-term ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>p</mi> <mo><</mo> <mn>0.01</mn>...
Tibial shaft fractures account for approximately 15% of long bone fractures. Locked plates with minimally invasive plate osteosynthesis techniques are used widely by surgeons. The purpose this study is to investigate the impact factors meaning length, fibula integrity, and placement on stability tibial fracture fixation.A finite element model was built. An axial force 2500 N applied simulate compressive load an adult knee during single-limb stance. equivalent von Mises stress displacement...