A5053561074- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Bayesian Inference
- Dementia and Cognitive Impairment Research
- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- COVID-19 epidemiological studies
- Advanced Causal Inference Techniques
- Obesity, Physical Activity, Diet
- Cutaneous Melanoma Detection and Management
- Pharmaceutical Practices and Patient Outcomes
- Chronic Disease Management Strategies
- Reliability and Agreement in Measurement
- Frailty in Older Adults
- COVID-19 and healthcare impacts
- Plant Virus Research Studies
- Diet and metabolism studies
- Statistical Methods in Clinical Trials
- Pregnancy and preeclampsia studies
- Health disparities and outcomes
- Blood Pressure and Hypertension Studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Food Security and Health in Diverse Populations
- Nutrition and Health in Aging
Centers for Disease Control and Prevention
2020-2024
Yale University
2016-2021
University of KwaZulu-Natal
2019
Gandhara University
2019
New Haven Public Schools
2018
Wageningen University & Research
2014-2016
National Institute for Public Health and the Environment
2014-2016
Abstract Background Evidence surrounding the effect of adjuvant treatment in salivary gland cancers is limited. The benefit adding chemotherapy to also interest. We investigated association these treatments with survival and whether this differed by stage or presence adverse features. Methods A retrospective study adult cancer cases diagnosed from 2004 2013 National Cancer Data Base (NCDB) was conducted. Results Treatment radiotherapy associated improved for both patients early‐stage (hazard...
Melanoma is among the most common malignant neoplasms in United States, with 91 270 cases estimated to be diagnosed 2018. Since 2012, Mohs micrographic surgery (MMS) has gained popularity treatment of melanoma situ. Although current guidelines for invasive without nodal metastases recommend wide margin excision (WME), use MMS this disease increased as well, particularly early stages. How survival outcomes after each procedure compare one another early-stage unknown date.To evaluate overall...
Our objectives were to evaluate: 1) the associations of cognitive frailty with various health outcomes including disability, hospitalization, and death; 2) whether differed by multimorbidity. We included data 5113 Chinese older adults (aged 60+ years) who had baseline cognition physical assessments (2011 wave) follow-up for 4 years. About 16.0% (n=820) impairment; 6.7% (n=342) frailty; 1.6% (n=82) met criteria frailty. Both impairment (odds ratios (ORs) range: 1.41 2.11) (ORs 1.51 2.43)...
To investigate the prospective association of frailty status, especially early stage, with long-term risk Gastroesophageal reflux disease (GERD) in a large cohort. We included participants who were free GERD and cancer at baseline use aspirin non-steroidal anti-inflammatory drugs (NSAIDs) from UK Biobank (UKB). Frailty status was assessed using Fried phenotype including five items (weight loss, exhaustion, low grip strength, physical activity, slow walking pace) classified as non-frail,...
ABSTRACT Background: Longitudinal studies of older adults are characterized by high dropout rates, multimorbid conditions, and multiple medication use, especially proximal to death. We studied the association between use incident dementia diagnoses including Alzheimer's disease (AD), vascular (VD), Lewy-body (LBD), simultaneously accounting for dropout. Methods: Using National Coordinating Center data with three years follow-up, a set covariate-adjusted models that ignore was fit...
Background: Prior work suggests that asthma–COPD overlap syndrome (ACOS) has a greater health burden than asthma alone or COPD alone. In the current study, we have further evaluated of ACOS in nationally representative sample US population, focusing on patient-reported outcomes and care utilization comparisons with Patient-reported are especially meaningful, as these include functional activities highly valued by patients basis for patient-centered care. Methods: Using data from Medical...
Use of potentially inappropriate medications (PIM) among people with dementia is common. We assessed the patterns medication use from 1-year before diagnosis, to after compared in without dementia. conducted longitudinal study using National Alzheimer's Coordinating Center data. Adults aged 65 years and older newly diagnosed (n = 2,418) during 2005–2015 were year, age, sex matched 1:1 controls. Generalized estimating equation models weighted for missingness adjusted 15 participant...
Merkel cell carcinoma (MCC) carries the highest mortality rate among cutaneous cancers and is rapidly rising in incidence. Identification of prognostic indicators may help guide patient counseling treatment planning. Lymph node ratio (LNR), positive lymph nodes to total number examined nodes, an established indicator other cancers.The primary objective was evaluate association between LNR survival after surgery for node-positive MCC. The secondary whether rates associated with adjuvant...
Typhoid fever burden can vary over time. Long-term data inform prevention strategies; however, such are lacking in many African settings. We reexamined typhoid incidence and antimicrobial resistance (AMR) a 10-year period Kibera, densely populated urban informal settlement where high has been previously described. used from the Population Based Infectious Diseases Surveillance platform to estimate crude adjusted rates prevalence of AMR nearly 26,000 individuals all ages. Demographic...
Robust data on the impact of COVID-19 pandemic mortality in Africa are relatively scarce. Using from two well-characterized populations Kenya we aimed to estimate excess during period. The arise an ongoing population-based infectious disease surveillance (PBIDS) platform, which has been operational since 2006 rural western (Asembo, Siaya County) and urban informal settlement (Kibera, Nairobi County), Kenya. PBIDS participants were regularly visited at home (2–3 times a year) by field workers...
Abstract Women infected during pregnancy with TORCH (Toxoplasmosis, Other, Rubella, Cytomegalovirus, and Herpes simplex viruses) pathogens have a higher risk of adverse birth outcomes including stillbirth / miscarriage because mother-to-child transmission. To investigate these risks in pregnant women Kenya, we analyzed serum specimens from cohort study at three healthcare facilities. A sample 481 participants was selected for pathogen antibody testing to determine seroprevalence. random...
Abstract We examined the association between serum aflatoxin B1‐lysine adduct (AFB1‐lys) levels in pregnant women and adverse pregnancy outcomes (low birthweight, miscarriage stillbirth) through a nested matched case–control study of enroled at ≤28 weeks' gestation Mombasa, Kenya, from 2017 to 2019. Cases comprised with an birth outcome, defined as either delivery singleton infant weighing <2500 g, or miscarriage, stillbirth, while controls were who delivered live birthweight ≥2500 g....
In epidemiologic studies, measurement error in dietary variables often attenuates association between intake and disease occurrence. To adjust for the attenuation caused by intake, regression calibration is commonly used. apply calibration, unbiased reference measurements are required. Short-term foods that not consumed daily contain excess zeroes pose challenges model. We adapted two-part model, initially developed multiple replicates of per individual to a single-replicate setting. showed...
Potentially inappropriate medication (PIM) use in older adults with dementia is an understudied area. We assessed longitudinal changes PIM exposure by type following diagnosis.We followed 2448 participants aged ≥65 years (52% women, 85.5% Caucasian, mean age 80.9 ± 7.5 years) diagnosed after enrollment the National Alzheimer's Coordinating Center (2005-2014). estimated association between and annually for 2 diagnosis, using Generalized Estimating Equations.Participants Lewy body had more...
Abstract Introduction More persons with dementia are residing in the community as many countries shift from residential care to home and care. Although there forms of support available avoid crisis situations prolong living, it remains unclear how these valued by community‐dwelling their informal caregivers. Understanding perspectives caregivers on characteristics is a vital step valuing services. This study aims prioritize for use an innovative mixed‐methods approach. Methods Six mixed...
Measurement error in exposure variables is a serious impediment epidemiological studies that relate exposures to health outcomes. In nutritional studies, interest could be the association between long‐term dietary intake and disease occurrence. Long‐term usually assessed with food frequency questionnaire (FFQ), which prone recall bias. FFQ‐reported intakes leads bias parameter estimate quantifies association. To adjust for association, calibration study required obtain unbiased measurements...
Abstract Increased attention has been paid to circadian patterns and how predisposition metabolic disorders can be affected by meal timing. Currently, it is not clear which role attributed the foods selected at meals. On a cross-sectional sub-cohort study (815 adults) within European Prospective Investigation into Cancer Nutrition-Potsdam study, we investigated whether same (vegetables, fruits, refined grains, whole red processed meats) eaten different meals (breakfast, lunch or dinner) show...