A5080254964- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Liver physiology and pathology
- Ultrasound Imaging and Elastography
- Advanced MRI Techniques and Applications
- Infrared Thermography in Medicine
- Medical Imaging and Pathology Studies
- Lanthanide and Transition Metal Complexes
- Thyroid and Parathyroid Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic and Kidney Cyst Diseases
- Thyroid Cancer Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Ultrasound in Clinical Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Drug Transport and Resistance Mechanisms
- Phagocytosis and Immune Regulation
- Liver Diseases and Immunity
- Radiomics and Machine Learning in Medical Imaging
- Systemic Sclerosis and Related Diseases
Tianjin First Center Hospital
2021-2025
Tianjin Medical University
2021-2025
Mayo Clinic in Arizona
2025
Mayo Clinic
2023-2024
Nankai University
2021-2024
Guangxi Medical University
2024
First Affiliated Hospital of GuangXi Medical University
2024
Siemens Healthcare (United States)
2022
Siemens Healthcare (Germany)
2022
Serum creatinine (Scr) may be not suited to timely and accurately reflect kidney injury related chronic liver disease. Currently, the ability of arterial spin labeling (ASL) blood oxygen level-dependent (BOLD) sequences evaluate renal flow (RBF) in disease remains verified.
MR elastography (MRE) at 60 Hz is widely used for staging liver fibrosis. MRE with lower frequencies may provide inflammation biomarkers. To establish a practical simultaneous dual-frequency protocol both 30 and during single examination validate the occurrence of second harmonic waves Hz. Retrospective. One hundred six patients (48 females, age: 50.0 ± 13.4 years) were divided as follows: Cohort (15 chronic disease [CLD] 25 healthy volunteers) MRE. Two (66 CLD) 3-T, single- or Liver...
Background Arterial spin labeling (ASL) has been proven to be effective in ischemia‐induced acute kidney injury (AKI); however, validation of ASL magnetic resonance imaging (MRI) is limited AKI the presence cirrhosis. Purpose To investigate feasibility revealing renal blood flow (RBF) changes cirrhosis and assess its value early diagnosis disease. Study Type Longitudinal. Animal Model Rats were randomized into baseline group ( N = 3), sham surgery 18), common bile duct ligation (BDL) 48)....
This study investigated the dynamic changes of residual right liver lobe after left lateral sectionectomy (LLS) and potential value IVIM T2* mapping in evaluation regeneration living donors. All indexes showed no obvious surgery, but values increased significantly at 2 weeks kept increasing gradually from week to 8. Liver correlated moderately with volume, it may be a good substitute volume evaluating
Motivation: While DAAs have significantly improved the treatment of HCV patients, some individuals still face relapse or progression. There is currently a deficiency in non-invasive and simple methods for effectively monitoring longitudinal effects. Goal(s): To develop reliable biomarker detecting inflammatory response to DAA early stages infection. Approach: Longitudinal changes early-stage patients after using multiparametric MRE. Results: Multi-parameter MRE can detect at stage monitor...
The current risk stratification methods for Pediatric Differentiated Thyroid Carcinoma (DTC) are deemed inadequate due to the high recurrence rates observed in this demographic. This study investigates alternative clinicopathological factors, specifically Central Lymph Node Ratio (CLNR), improved pediatric DTC.
Purpose We investigated the capability and imaging criteria of T1 mapping arterial spin labeling (ASL) MRI to identify renal injury in patients with liver cirrhosis. Methods recruited 27 cirrhosis normal function (cirrhosis-NR), 10 dysfunction (cirrhosis-RD) 23 controls (NCs). All participants were examined via ASL imaging. Renal blood flow (RBF) derived from was measured cortex, values parenchyma (cortex medulla). parameters compared between groups. Diagnostic performances for detecting...
Motivation: Hepatic fibrosis, despite traditionally viewed as a diffuse occurrence, has been shown to vary spatially with disease progression. Goal(s): MR elastography (MRE) measures mechanical properties and their spatial variations can potentially provide holistic insights into tissue inhomogeneity. Approach: Twenty-five rats based metabolic dysfunction associated steatotic liver (MASLD) model monthly underwent MRE investigate inhomogeneity during cirrhosis development. Results: Results...
Motivation: Noninvasive and sensitive methods for assessing chronic liver disease-associated kidney injury are needed in clinics. Goal(s): We investigated the potential of arterial spin labeling (ASL) blood oxygenation level-dependent (BOLD) MRI diagnosing evaluating progression. Approach: observed renal flow (RBF) T2* changes rats with CCl4-induced disease compared imaging, pathological, biochemical indicators at different time points. Results: During development rats, RBF gradually...
To determine whether intravoxel incoherent motion (IVIM) parameters correlate with liver regeneration and function recovery after partial hepatectomy (PH) in rats carbon tetrachloride (CCl4)-induced fibrosis.Sixty-two adult Sprague-Dawley were divided into the control group fibrosis CCl4 injection for 8 weeks. At end of 8th week, all received left lateral lobe resection. Within each group, IVIM imaging (n = 10/group) histologic biochemical analyses 3/group/time point) performed pre- post-PH...
We aimed to evaluate the correlation between pathological changes and multi-parameter MRI characteristics of liver regeneration (LR) in a standard partial hepatectomy (PH) rat model.Seventy Sprague-Dawley rats were randomly divided into two groups: MR scan group (n = 14) pathologic analysis (PA) 56). All 14 underwent T1 mapping, T2 diffusion kurtosis imaging before 1st, 2nd, 3rd, 5th, 7th, 14th, 21st day after 70% hepatectomy. Seven PA euthanized at each time point determine Ki-67 indices,...
Different diffusion weighted imaging (DWI) models were used to evaluate microscopic changes of residual liver in rats after standard partial hepatectomy (70%PH). Multiple b-value DWI at multiple timepoints 70%PH acquired, and the data was analyzed using three models: conventional monoexponential DWI, intravoxel incoherent motion (IVIM), kurtosis (DKI) models. Compared with model IVIM DKI can describe blood supply process regeneration provide added value evaluating microstructure hepatectomy.
This study investigated the feasibility of IVIM to evaluate fibrotic liver regeneration and function recovery after partial hepatectomy in a rat model. In rats, significant increase D values decrease D* PF followed with pre-PH levels were shown. correlated well Ki-67 indices, ALT, AST, TBil values. may be an noninvasive promising approach monitor functional PH.
Abstract Background : We aimed to evaluate the correlation between pathological changes and multi-parameter MRI characteristics of liver regeneration (LR) in a standard partial hepatectomy (PH) rat model. Methods Seventy Sprague-Dawley rats were randomly divided into two groups: MR scan group (n = 14) pathologic analysis (PA) 56). All 14 underwent T1 mapping, T2 diffusion kurtosis imaging (DKI) before 1st, 2nd, 3rd, 5th, 7th, 14th, 21st day after 70% hepatectomy. Seven PA euthanized at each...