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Contact & Profiles
A5070993408
Research Areas
- Sleep and Wakefulness Research
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
Kansai Medical University
2021
Abstract Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal hypoxic conditions. Here, we show that most of these effects are severely attenuated transient receptor potential ankyrin 1 ( Trpa1 ) knockout mice. TFO-induced hypothermia involves the -mediated trigeminal/vagal pathways non- olfactory pathway. TFOs activate -positive sensory projecting from trigeminal vagal ganglia to spinal nucleus...
10.1038/s41467-021-22205-0
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Nature Communications
2021-04-06
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