A5100745885- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Plant-based Medicinal Research
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Luminescence Properties of Advanced Materials
- Glioma Diagnosis and Treatment
- Phytochemical Studies and Bioactivities
- Bioactive Natural Diterpenoids Research
- Photodynamic Therapy Research Studies
- Drug Solubulity and Delivery Systems
- Metabolomics and Mass Spectrometry Studies
- Brain Tumor Detection and Classification
- Mast cells and histamine
- Amino Acid Enzymes and Metabolism
- Microbial Community Ecology and Physiology
- Probiotics and Fermented Foods
- MicroRNA in disease regulation
- Plant biochemistry and biosynthesis
- Psoriasis: Treatment and Pathogenesis
- Bioactive Compounds and Antitumor Agents
- Nanopore and Nanochannel Transport Studies
Nanjing University of Chinese Medicine
2024
China Pharmaceutical University
2022-2024
University of Shanghai for Science and Technology
2023
Changzhou No.2 People's Hospital
2023
Soochow University
2023
China University of Petroleum, Beijing
2023
ZTE (United States)
2023
Hebei Medical University
2022
Fourth Hospital of Hebei Medical University
2022
Kunming Medical University
2022
Hepatocellular carcinoma (HCC) is frequently metastatic once diagnosed and less likely to respond curative surgery, emphasizing the need for development of more sensitive effective diagnostic therapeutic strategies.
Pancreatic cancer remains the leading cause of cancer-related deaths, existence stem cells and lack highly efficient early detection may account for poor survival rate. Gadolinium ion-doped upconversion nanoparticles (UCNPs) provide opportunities combining fluorescent with magnetic resonance imaging, they can improve diagnostic efficacy pancreatic cancer. In addition, as one transmembrane glycoprotein overexpressed on cells, CD326 act a promising target. this study, we developed facile...
Abstract Background Triple negative breast cancer (TNBC) is an aggressive tumor with extremely high mortality that results from its lack of effective therapeutic targets. As adhesion molecule related to tumorigenesis and metastasis, cluster differentiation-44 (also known as CD44) overexpressed in TNBC. Moreover, CD44 can be effectively targeted by a specific hyaluronic acid analog, namely, chitosan oligosaccharide (CO). In this study, CO-coated liposome was designed, Photochlor (HPPH) the...
Abstract Background Glioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment one of daunting challenges in oncology. The blood–brain barrier (BBB) main obstacle that prevents delivery potentially active therapeutic compounds. In this study, a new type pH-sensitive polymersomes has been designed for glioblastoma therapy to achieve combination radiotherapy chemotherapy U87-MG human xenografts nude mice significantly increased survival time. Results...
The c-myc proto-oncogene, which is crucial for the progression of many human cancers, has been implicated in key cellular processes diverse cell types, including endothelial cells that line blood vessels and are critical angiogenesis. de novo differentiation known as vasculogenesis, whereas growth new from pre-existing To ascertain function vascular development, we deleted selected lineages. Embryos lacking hematopoietic lineages phenocopied those entire embryo proper. At embryonic day (E)...
Targeting NLRP3 inflammasome with inhibitors is a novel strategy for NLRP3-driven diseases. Herein, hit compound
Radiation therapy (RT) is commonly used to treat glioblastoma, but its immunomodulatory effect on tumors, through mechanisms such as immunogenic cell death (ICD), relatively weak. Gold nanoparticles (AuNPs) have been suggested potential radio-sensitizers, it unclear if they can enhance radiation-induced ICD. This study aimed investigate the of AuNPs improve effectiveness ICD.G422 cells were treated with a combination and RT induce death. Various assays conducted assess death, surface...
Inducing the immunogenic cell death of tumour cells can mediate occurrence antitumour immune responses and make therapeutic effect more significant. Therefore, development treatments that induce ICD to destroy most effectively is promising. Previously, a new type pH-sensitive polymersome was designed for treatment glioblastoma which represents promising nanoplatform future translational research in therapy. In this study, aim work analyse whether chemoradiotherapy novel cargo-loaded...
Abstract The widespread use of Covid-19 mRNA vaccines has highlighted the need to address rare but concerning side effects. Systemic off-target gene expression been identified as a primary cause acute adverse reactions and effects associated with nucleoside-modified vaccines. In this study, we incorporated permanent cationic lipid Dotap component into mRNA-LNP formula FDA-approved vaccine Comirnaty create novel positively charged LNP carrier for delivery. Using optimized prepare SARS-Cov-2...
Abstract Background Oral squamous cell carcinoma (OSCC) is the most common neck and head malignancies, prognosis not good. Studies shown that long non-coding RNA (lncRNA) TFAP2A-AS1 involved in progression of multiple cancers. However, role lncRNA OSCC remains unclear. We aimed to explore functions expression OSCC. Methods The profiles for patients were acquired from TCGA. Based on these data, data mining with performed. determined by bioinformatics analysis. roles growth tested RT-qPCR MTS...
  Dissolved organic matter (DOM) in soil consists of a diverse mixture water-soluble (SOM) molecules that are highly mobile and reactive. These play various roles with different capacities biogeochemical processes. Theoretically, the persistence DOM soils is controlled by interactions between i) leaching desorption release from plant residues SOM ii) sorption decomposition remove DOM. However, there still no consensus on dominant factor(s) or dimension(s) driving yield molecular...
To improve the accuracy of clinical diagnosis severe patients with advanced liver cancer and enhance effect chemotherapy treatment, U-Net model was optimized by introducing batch normalization (BN) layer dropout layer, segmentation training verification were realized magnetic resonance (MR) image data. Subsequently, HepG2 cells taken as research objects treated 0, 10, 20, 40, 60, 80, 100 μmol/L emodin (EMO), respectively. The methyl thiazolyl tetrazolium (MTT) method used to explore changes...
A new lignan eplignan (1), along with six konwn lignans (2-7) was isolated from the herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer.Their structures were elucidated based on spectroscopic evidence, mainly including NMR and HRESIMS data.The absolute configuration 1 determined by comparing calculated experimental electronic circular dichroic (ECD) spectra.Moreover, all compounds (1-7) evaluated for their protective effects against BEAS-2B cells injury induced TGF-β1 in vitro,...