A5046228709- Head and Neck Cancer Studies
- Molecular Biology Techniques and Applications
- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Dysphagia Assessment and Management
- Lung Cancer Research Studies
- Esophageal and GI Pathology
- RNA modifications and cancer
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Virus-based gene therapy research
- Genomics, phytochemicals, and oxidative stress
- Aldose Reductase and Taurine
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Heme Oxygenase-1 and Carbon Monoxide
Maastricht University
2015-2025
Maastricht University Medical Centre
2018-2022
University Medical Center
2021
State of Illinois
2020
Human papillomavirus (HPV)‑positive and -negative head neck squamous cell carcinoma (HNSCC) are often associated with activation of the phosphatidylinositol 3‑kinase (PI3K)/Akt/mammalian target rapamycin (mTOR) pathway due to mutations or amplifications in
Objective The purpose of this study was to determine the relationship between patient‐reported symptoms oropharyngeal dysphagia (OD) using Eating Assessment Tool (EAT)‐10 and swallowing function a standardized fiberoptic endoscopic evaluation (FEES) protocol in head neck cancer (HNC) patients with confirmed OD. Methods Fifty‐seven dysphagic HNC completed EAT‐10 FEES. Two blinded clinicians scored randomized FEES examinations. Exclusion criteria consisted presenting concurrent neurological...
Different studies have shown that HPV16‐positive OPSCC can be subdivided based on integration status (integrated, episomal and mixed forms). Because we showed neither affects the levels of viral genes, nor those virally disrupted human a genome‐wide screen was performed to identify genes which expression is influenced by clinical relevance. Thirty‐three fresh‐frozen HPV‐16 positive samples with known were analyzed mRNA profiling. Among interest, Aldo‐keto‐reductases 1C1 1C3 (AKR1C1, AKR1C3)...
Abstract Background The purpose of this study was to determine the relationship between swallow‐specific quality life (QOL) using MD Anderson Dysphagia Inventory (MDADI) and swallowing function a standardized fiber‐optic endoscopic evaluation (FEES) protocol in patients with dysphagia head neck cancer. Methods Sixty‐three cancer were enrolled study. Patients completed MDADI questionnaire underwent FEES examination. Ordinal variables measured. Descriptive statistics 1‐way analysis variance...
Early diagnosis of human papillomavirus (HPV) associated oropharyngeal cancer (OPC) is with improved survival. To achieve early diagnosis, it might be beneficial to increase awareness the link between HPV and OPC. This could also an important way vaccination rates. The aim our study was explore current public knowledge in Netherlands regarding association OPC.An online cross-sectional survey used sent by company Flycatcher Internet Research 1539 their panel members. Data were analyzed...
Cidofovir (CDV) is an antiviral agent with antiproliferative properties. The aim of our study was to investigate the efficacy CDV in HPV-positive and -negative head neck squamous cell carcinoma (HNSCC) lines whether it caused by a difference response DNA damage. Upon treatment HNSCC normal oral keratinocyte lines, we carried out MTT analysis (cell viability), flow cytometry cycle analysis), (immuno) fluorescence western blotting (DNA double strand breaks, damage response, apoptosis mitotic...
Abstract Introduction: Both HPV-positive and -negative head neck squamous cell carcinoma (HNSCC) often show activation of the PI3K/AKT/mTOR pathway, due to, amongst others, PI3KCA mutations, PTEN loss, or receptor tyrosine kinase activation. In HPV-negative tumors, CDKN2A (p16) inactivation CCND1 (cyclin D1) amplification frequently occurs resulting in sustained cyclin dependent (CDK) 4/6 The aim our study was to investigate efficacy pathway inhibitors (PI3Ki) (alpelisib, buparlisib...
The incidence of human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is increasing in high income countries. HPV-associated OPC generally presents as an invasive disease, often with lymph node involvement, relatively young patients minimal or no history smoking and alcohol consumption. Knowledge on among primary care professionals essential for disease recognition early start treatment.To examine the knowledge GPs Netherlands.A cross-sectional postal survey 12-item questionnaire...
Objectives: Cidofovir (CDV) is an antiviral agent with anti-proliferative properties and suggested as treatment option in head neck squamous cell carcinoma (HNSCC) patients to improve outcome quality of life. The mechanisms underlying the effectivity CDV are not completely understood. aim our study was investigate efficacy HPV-positive -negative HNSCC lines vitro whether it caused by a difference response DNA damage.Materials methods: Upon HNSCC-, uterine cervical (UCC)- immortalized NOK-...
Abstract Objectives: Cidofovir (CDV) is an antiviral agent with anti-proliferative properties and suggested as treatment option in head neck squamous cell carcinoma (HNSCC) patients to improve outcome quality of life. The mechanisms underlying the effectivity CDV are not completely understood. aim our study was investigate efficacy HPV-positive -negative HNSCC lines vitro whether it caused by a difference response DNA damage. Materials methods: Upon HNSCC-, uterine cervical (UCC)-...