A5100734241- RNA Research and Splicing
- RNA modifications and cancer
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- Listeria monocytogenes in Food Safety
- Cancer, Hypoxia, and Metabolism
- COVID-19 epidemiological studies
- DNA and Nucleic Acid Chemistry
- Plant Reproductive Biology
- Genomics and Chromatin Dynamics
- Wheat and Barley Genetics and Pathology
- TGF-β signaling in diseases
- Plant nutrient uptake and metabolism
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- Medical Device Sterilization and Disinfection
- Antimicrobial Resistance in Staphylococcus
- Turfgrass Adaptation and Management
- Genomics, phytochemicals, and oxidative stress
- Yeasts and Rust Fungi Studies
Huaqiao University
2018-2025
Harbin Medical University
2009-2024
Second Affiliated Hospital of Harbin Medical University
2015-2024
Henan Provincial Center for Disease Control and Prevention
2024
Zhengzhou University
2022-2023
Henan University of Engineering
2023
Henan Provincial Institute of Occupational Health
2022
Sichuan Agricultural University
2018-2020
Anhui University of Science and Technology
2020
South China University of Technology
2014-2019
Abstract Late embryogenesis abundant (LEA) proteins are a diverse and large group of polypeptides that play important roles in desiccation freezing tolerance plants. The LEA family has been systematically characterized some plants but not Brassica napus . In this study, 108 BnLEA genes were identified the B. genome classified into eight families based on their conserved domains. Protein sequence alignments revealed an abundance alanine, lysine glutamic acid residues proteins. gene structure...
Abstract Long non-coding (lnc) RNAs represent a fascinating class of transcripts that remains highly controversial mainly due to ambiguity surrounding overall biological relevance these RNAs. Multitude reverse genetics studies showing functionality lncRNAs are unfortunately based on assays either plagued by non-specific effects and/or cannot unambiguously assign observed phenotypes the transcript per se . Here, we show application novel CRISPR/Cas13 RNA knockdown system has superior...
Livestock-associated Staphylococcus aureus colonization and/or infections exist in pigs and people frequent contact with pigs. In this study, a total of 130 S. isolates obtained from different stages pork production were subjected to antimicrobial susceptibility, biofilm formation, as well PCR screening identify virulence genes, the accessory gene regulator alleles (agr). Among all isolates, 109 (83.8%, 109/130) positive for agr. All swine farms belonged agr IV, whereas isolated...
Abstract Single-strand breaks (SSBs) represent the major form of DNA damage, yet techniques to map these lesions genome-wide with nucleotide-level precision are limited. Here, we present a method, termed SSiNGLe, and demonstrate its utility explore distribution dynamic changes in SSBs response different biological environmental stimuli. We validate SSiNGLe using two very distinct sequencing apply it derive global profiles states. Strikingly, show that patterns genome non-random, specific...
The extent of functional sequences within the human genome is a pivotal yet debated topic in biology. Although high-throughput reverse genetic screens have made strides exploring this, they often limit their scope to known genomic elements and may introduce non-specific effects. This underscores urgent need for novel genomics tools that enable deeper, unbiased understanding functionality. protocol introduces Insertion-based Screen Elements Transcripts (InSET), method identifying lentivirus...
Recovery of the root system following physical damage is an essential issue for plant survival. An injured able to regenerate by increases in lateral (LR) number and acceleration growth. The horticultural technique pruning (root cutting) application this response a common garden controlling Although widely used, molecular mechanisms underlying subsequent changes are poorly understood. In study, was employed as model study regeneration. Notably, LR defects wild-type plants treated with...
Small ubiquitin-related modifiers (SUMO) represent a class of ubiquitin-like proteins that are conjugated, like ubiquitin, by set enzymes to form cellular regulatory proteins, and play key roles in the control cell proliferation, differentiation, apoptosis. We found ginkgolic acid (GA) can significantly reduce vitality dose- time-dependent manner also accelerate cyto-apoptosis both Tca8113 Cal-27 cells. Migration wound-healing assays were executed determine anti-migration effect GA oral...
Abstract Background The majority of the human genome is transcribed in form long non-coding (lnc) RNAs. While these transcripts have attracted considerable interest, their molecular mechanisms function and biological significance remain controversial. One main reasons behind this lies significant challenges posed by lncRNAs requiring development novel methods concepts to unravel functionality. Existing often lack cross-validation independent confirmation different methodologies therefore...
Abstract Background Conversion or editing of adenosine (A) into inosine (I) catalyzed by specialized cellular enzymes represents one the most common post-transcriptional RNA modifications with emerging connection to disease. A-to-I conversions can happen at specific sites and lead increase in proteome diversity changes stability, splicing, regulation. Such be detected as adenine-to-guanine sequence next-generation sequencing which resulted millions reported from multiple genome-wide surveys....
Objective To assess lifestyles, COVID-19 vaccination coverage rates, and the relationships between lifestyles among Chinese population. Methods We collected data on sociodemographics, perception of pandemic, self-reported via an online survey in China. The chi-square goodness-of-fit test was used to monitor sample saturation throughout formal survey. binary logistic regression analyses were conducted examine association rate lifestyle score. assigned values 12 ranging from positive negative,...
Single-strand breaks (SSBs) represent one of the most common types DNA damage, yet not much is known about genome landscapes this type lesions in mammalian cells. Here, we found that SSBs are more likely to occur certain positions human genome-SSB hotspots-in different cells same cell and types. We hypothesize hotspots biologically relevant breaks. Furthermore, had a prominent tendency be enriched immediate vicinity transcriptional start sites (TSSs). show these technical artifacts or caused...
The development of coresistance to disinfectants and heavy metals contributes the fitness Listeria spp. in foods or food processing environments, where life-threatening monocytogenes coexist coevolve with other Despite extensive research on L. monocytogenes, is less documented for In this study, we screened 30 27 innocua isolates recovered from 273 swine samples resistance quaternary ammonium compound benzalkonium chloride (BC) cadmium (Cd) arsenic (As). Moreover, evaluated potential...
Abstract Aims and Objectives To investigate whether chronic diseases are associated with higher COVID‐19 vaccine hesitancy explore factors that influence in patients diseases. Background Vaccine has been acknowledged as one of the greatest hazards to public health. However, little information is available about among who may be more susceptible infection, severe disease or death. Methods From 6 9 August 2021, we performed an internet‐based cross‐sectional survey 22,954 participants (14.78%...