A5011275972- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- vaccines and immunoinformatics approaches
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Marine Sponges and Natural Products
- Synthetic Organic Chemistry Methods
- Atherosclerosis and Cardiovascular Diseases
- Advanced Synthetic Organic Chemistry
- Prenatal Screening and Diagnostics
- Plant Toxicity and Pharmacological Properties
- Cardiac Fibrosis and Remodeling
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
- Fungal Biology and Applications
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
St. Laurent Institute
2016-2023
Siberian Branch of the Russian Academy of Sciences
2023
A.P. Ershov Institute of Informatics Systems, Siberian Branch of the Russian Academy of Sciences
2023
Immanuel Kant Baltic Federal University
2022
Wound healing involves an orchestrated response that engages multiple processes such as hemostasis, cellular migration, extracellular matrix synthesis, and in particular, inflammation. Using a murine model of cutaneous wound repair, the transcriptome was mapped from 12 hours to 8 days post-injury, multicomponent, multi-target natural product, Tr14. single-molecule RNA sequencing (RNAseq), there were clear temporal changes known transcripts related pathways, additional novel both coding...
The COVID-19 pandemic was the most dramatic in newest history with nearly 7 million deaths and global impact on mankind. Here, we report binding index of 305 human leukocyte antigen (HLA) class I molecules from 18,771 unique haplotypes 28,104 individuals to 821 peptides experimentally observed spike protein receptor domain (RBD) five main SARS-CoV-2 strains hydrolyzed by proteasomes constitutive immune catalytic phenotypes. Our data read that mutations angiotensin-converting enzyme 2...
Abstract Marine sponges harbor diverse communities of associated organisms, including eukaryotes, viruses, and bacteria. Sponge microbiomes contribute to the health host organisms by defending them against invading bacteria providing with essential metabolites. Here we describe three sympatric species cold-water marine – Halichondria panicea , sitiens Isodictya palmata sampled over a period six years at White Sea. We identified as low microbial abundance detected stably that represent new...
Functionality of the non-coding transcripts encoded by human genome is coveted goal modern genomics research. While commonly relied on classical methods forward genetics, integration different datasets in a global Systems Biology fashion presents more productive avenue achieving this very complex aim. Here we report application Biology-based approach to dissect functionality newly identified vast class long intergenic (vlinc) RNAs. Using highly quantitative FANTOM5 CAGE dataset, show that...
Abstract Background The majority of the human genome is transcribed in form long non-coding (lnc) RNAs. While these transcripts have attracted considerable interest, their molecular mechanisms function and biological significance remain controversial. One main reasons behind this lies significant challenges posed by lncRNAs requiring development novel methods concepts to unravel functionality. Existing often lack cross-validation independent confirmation different methodologies therefore...
MicroRNAs (miRNAs) constitute a class of small noncoding RNAs that plays an important role in the post-transcriptional regulation gene expression. Much evidence has demonstrated miRNAs are involved regulating human and mouse pluripotency. Nevertheless, to our knowledge, pluripotent stem cells one most commonly used model organisms - Rattus norvegicus have not been studied. In present study, we performed deep sequencing RNA molecules embryonic fibroblasts, cells, induced laboratory rats....
Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome Traumeel (Tr14), a multicomponent natural product, and diclofenac, non-selective cyclooxygenase (COX) inhibitor, were compared mouse cutaneous wound healing model to identify both known novel pathways for anti-inflammatory effect plant-derived products.Skin samples from abraded mice analyzed by single-molecule, amplification-free RNAseq...
SUMMARY The COVID-19 pandemic was the most dramatic in newest history with nearly 7 million deaths and global impact on mankind. Here we report binding index of 305 HLA class I molecules from 18,771 unique haplotypes 28,104 individuals to 821 peptides experimentally observed spike protein RBD 5 main SARS-CoV-2 strains hydrolyzed by human proteasomes constitutive immune catalytic phenotypes. Our data read that mutations hACE2-binding region 496-513 Omicron B.1.1.529 strain results a increase...
<h3>Background</h3> Anti-inflammatory agents are used widely in treating numerous pain and inflammatory conditions. With a focus on the specialised pro-resolving mediators (SPM) pathways cutaneous wound repair mice, therapeutic activities of Tr14 (Traumeel), multicomponent/multitarget natural product, diclofenac (NSAID), non-selective cyclooxygenase (COX) inhibitor were compared. COX inhibitors can block synthesis prostaglandins thromboxanes from arachidonic acid, have important effects...
<h3>Background</h3> Anti-inflammatory agents are used widely in treating numerous pain and inflammatory conditions. With a focus on the COX/LOX pathways cutaneous wound repair mice, therapeutic activities of Tr14 (Traumeel), multicomponent/multitarget natural product, diclofenac (NSAID), non-selective cyclooxygenase (COX) inhibitor were compared. The COX enzymes convert arachidonic acid into prostaglandins thromboxanes, while lipoxygenase (LOX) pathway generates more pro-inflammatory...
ABSTRACT Using low-coverage, whole-genome sequences of trophectoderm biopsies from 11,610 human blastocyst-stage embryos, we analyzed the relationship between chromosomal abnormalities and mitochondrial (mt) DNA dynamics. Comparing 6,208 aneuploid 5,402 euploid embryos in cohort studies, found that mtDNA content was significantly higher than embryos. This outcome confirmed through intrafamilial analyses with matched parents vitro fertilization cycles, it occurred independent maternal age....
Self-renewal of cultured pluripotent stem cells is a complex process, which includes multiple functional and regulatory levels. Transcription factors, their target genes, chromatin modifiers, signaling pathways, noncoding RNAs are involved in the maintaining self-renewal. Studies molecular genetic bases self-renewal pluripotency mammalian important to understand processes preimplantation embryogenesis develop efficient techniques obtain cell lines for experimental biology medicine. MicroRNAs...
Abstract Background: Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome Tr14 (Traumeel), a multicomponent natural product, and diclofenac, non-selective cyclooxygenase (COX) inhibitor, were compared mouse cutaneous wound healing model to identify both known novel pathways for anti-inflammatory effect plant-derived products. Methods: Skin samples from abraded mice analyzed by...