A5014960369- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Cancer-related Molecular Pathways
- Protein Tyrosine Phosphatases
- RNA Research and Splicing
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Neonatal Respiratory Health Research
- vaccines and immunoinformatics approaches
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Interconnection Networks and Systems
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Biotin and Related Studies
Institute of Bioorganic Chemistry
2016-2025
Kazan Federal University
2024
Institute of Bioorganic Chemistry
2020-2024
Russian Academy of Sciences
2015
Siberian Branch of the Russian Academy of Sciences
2013
Institute of Chemical Biology and Fundamental Medicine
2013
Neutrophil Extracellular Traps (NETs) have been implicated in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) pathogenesis. The myeloperoxidase–deoxyribonucleic acid (MPO-DNA) complex nucleosomes are serum markers of NETosis. aim this study was to assess these NETosis parameters as for SLE APS diagnosis their association with clinical features disease activity. A total 138 people were included the cross-sectional study: 30 without APS, 47 41 patients primary (PAPS), 20...
Recent findings indicate that the ubiquitin-proteasome system is involved in pathogenesis of cancer as well autoimmune and several neurodegenerative diseases, thus a target for novel therapeutics. One disease related to aberrant protein degradation multiple sclerosis, an disorder involving processing presentation myelin autoantigens leads destruction axons. Here, we show brain-derived proteasomes from SJL mice with experimental encephalomyelitis (EAE) ubiquitin-independent manner generate...
Introduction: The acute respiratory distress syndrome (ARDS), secondary to viral pneumonitis, is one of the main causes high mortality in patients with COVID-19 (novel coronavirus disease 2019)-ongoing SARS-CoV-2 infection- reached more than 0.7 billion registered cases. Methods: Recently, we elaborated a non-surgical and reproducible method unilateral total diffuse alveolar damage (DAD) left lung ICR mice-a publicly available imitation ARDS caused by SARS-CoV-2. Our data read that two C-C...
The COVID-19 pandemic was the most dramatic in newest history with nearly 7 million deaths and global impact on mankind. Here, we report binding index of 305 human leukocyte antigen (HLA) class I molecules from 18,771 unique haplotypes 28,104 individuals to 821 peptides experimentally observed spike protein receptor domain (RBD) five main SARS-CoV-2 strains hydrolyzed by proteasomes constitutive immune catalytic phenotypes. Our data read that mutations angiotensin-converting enzyme 2...
Systemic lupus erythematosus (SLE) is characterized by a systemic dysfunction of the innate and adaptive immune systems, leading to an attack on healthy tissues body. During development SLE, pathogenic features, such as formation autoantibodies self-nuclear antigens, caused tissue damage including necrosis fibrosis, with increased expression type Ⅰ interferon (IFN) regulated genes. Treatment immunosuppressants glucocorticoids, which are used standard therapy, not effective enough causes side...
Asymmetric cell division is a fundamental process conserved throughout evolution, employed by both prokaryotic and eukaryotic organisms. Its significance lies in its ability to govern fate facilitate the generation of diverse types. Therefore, attaining detailed mechanistic understanding asymmetric becomes essential for unraveling complexities determination healthy pathological conditions. However, role T-cell biology has only recently been unveiled. Here, we provide an overview field with...
A majority of thousands intracellular mammalian proteins are recognized by proteasome only being conjugated with ubiquitin (Ub), representing a universal degradation signal operated the ubiquitination system. Ub-independent targeting is rationalized existence 2 types direct signals (DPSs), specific amino acid sequences or post-translational modifications, which regulatory subunits. Historically, first type was shown to exist in ornithine decarboxylase, whereas acetylation core histones...
Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly. MBP highly positively charged lacks distinct structure solution therefore its intracellular partners are still mostly enigmatic. Here we used combination formaldehyde-induced cross-linking followed by immunoprecipitation liquid chromatography-tandem mass spectrometry (LC-MS/MS) to elucidate interaction network mammalian cells provide list...
Astrocytes are considered to be an important contributor central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released lymphocytes, penetrating the blood-brain barrier-in particular, classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here transcriptomal profiling astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that expression genes...
The possibility of targeted drug delivery to a specific tissue, organ, or cell has opened new promising avenues in treatment development. technology aims create multifunctional carriers that are capable long circulation the patient's organism and possess low toxicity at same time. surface modern synthetic high structural similarity membrane, which, when combined with additional modifications, also promotes transfer biological properties order penetrate physiological barriers effectively....
Infection caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) in many cases is accompanied release of a large amount proinflammatory cytokines an event known as "cytokine storm", which associated with disease 2019 (COVID-19) and high mortality. The excessive production linked, inter alia, to enhanced activity receptors capable recognizing conservative regions pathogens cell debris, namely TLRs, TREM-1 TNFR1. Here we report that peptides derived from innate immunity...
Myelin basic protein (MBP) is one of the key structural elements myelin sheath and has autoantigenic properties in multiple sclerosis (MS). Its intracellular interaction network still partially deconvoluted due to unfolded structure, abnormally charge, specific cellular localization. Here we used fusion MBP with TurboID, an engineered biotin ligase that uses ATP convert reactive biotin-AMP covalently attaches nearby proteins, determine interactome. Despite evident benefits, proximity...
Autophagy is a conservative and evolutionarily ancient process that enables the transfer of various cellular compounds, organelles, potentially dangerous components to lysosome for their degradation. This crucial recycling energy substrates, which are required biosynthesis. not only plays major role in survival cells under stress conditions, but also actively involved maintaining homeostasis. It has multiple effects on immune system remodeling during organism development. The effectiveness...