A5053166830- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Endoplasmic Reticulum Stress and Disease
- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Protein Degradation and Inhibitors
- Protein Tyrosine Phosphatases
- Drug-Induced Hepatotoxicity and Protection
- Fibroblast Growth Factor Research
- Systemic Lupus Erythematosus Research
- Genetic Syndromes and Imprinting
- Phytochemical and Pharmacological Studies
- Parathyroid Disorders and Treatments
- interferon and immune responses
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Natural Products and Biological Research
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- S100 Proteins and Annexins
- Pesticide Exposure and Toxicity
Yale University
2019-2020
Institute of Bioorganic Chemistry
2012-2019
Lomonosov Moscow State University
2014-2015
Russian Academy of Sciences
2015
Moscow State University
2011
Recent findings indicate that the ubiquitin-proteasome system is involved in pathogenesis of cancer as well autoimmune and several neurodegenerative diseases, thus a target for novel therapeutics. One disease related to aberrant protein degradation multiple sclerosis, an disorder involving processing presentation myelin autoantigens leads destruction axons. Here, we show brain-derived proteasomes from SJL mice with experimental encephalomyelitis (EAE) ubiquitin-independent manner generate...
The three members of the endocrine fibroblast growth factor (FGF) family designated FGF19, FGF21, and FGF23 mediate their pleiotropic cellular effects by binding to activating binary complexes composed an FGF receptor (FGFR) bound either α-Klotho or β-Klotho receptors. Structural analyses ligand-occupied Klotho extracellular domains have provided important insights concerning mechanisms underlying specificities FGF21 α-Klotho, respectively. They also demonstrated that proteins function as...
Significance FGF23 is a circulating hormone produced in bone tissue that acts the kidney to increase phosphate excretion and vitamin D metabolism essential for calcium absorption. Mutations elevate abundance cause autosomal dominant hypophosphatemic rickets or tumor-induced osteomalacia. Loss of FGF23, on other hand, causes increased levels, such as familiar tumor calcinosis. Here we show region responsible KLA binding contains two distinct sites KLA, demonstrating able simultaneously bind...
A majority of thousands intracellular mammalian proteins are recognized by proteasome only being conjugated with ubiquitin (Ub), representing a universal degradation signal operated the ubiquitination system. Ub-independent targeting is rationalized existence 2 types direct signals (DPSs), specific amino acid sequences or post-translational modifications, which regulatory subunits. Historically, first type was shown to exist in ornithine decarboxylase, whereas acetylation core histones...
Astrocytes are considered to be an important contributor central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released lymphocytes, penetrating the blood-brain barrier-in particular, classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here transcriptomal profiling astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that expression genes...
Organophosphate toxins (OPs) are the most toxic low-molecular compounds. The extremely potent toxicity of OPs is determined by their specificity toward nerve system. Human butyrylcholinesterase (hBChE) a natural bioscavenger against broad spectrum OPs, which makes it promising candidate for development DNA-encoded bioscavengers. high values protective index observed recombinant hBChE (rhBChE) make appropriate therapy OP poisoning, especially in case highly warfare agents. Nevertheless,...
We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the led us to attempt compensate or mimic its positive charge inhibit proteasomal degradation. demonstrated negatively charged actin calmodulin (CaM), as well histone H1.3, hydrolysis competing with MBP, respectively, for binding their counterpart. Interestingly, glatiramer acetate (GA), which used treat...
Pathologies of the hepatobiliary system occupy a significant share in total structure diseases. Morphological changes that develop liver during its toxic damage are based on cytolysis hepatocytes. Metabolic disorders arising from exposure to tetrachloromethane may alter production anti-inflammatory and cytokines by cells immune system. The aim our study was investigate reparative processes mechanisms rat tissues against background loading with aqueous extracts blackberry common sawfly...
The aim of the study was to investigate reparative processes and immune mechanisms in rat liver tissues against background loading with aqueous extracts blackberry common sawfly induced oxidative stress. 120 rats were used experiment. According group affiliation animals received a dose 50 mg/100g weight, 1.5 ml daily for 30 days, control distilled water same mode. Starting from days experiment, injected CCl4 6 days. On 37th day killed according ethical standards. number sinusoidal cells...