Abstract Animal models suggest transitions from non-addictive to addictive behavioral engagement are associated with ventral-to-dorsal striatal shifts. However, few studies have examined such features in humans, especially internet gaming disorder (IGD), a proposed addiction. We recruited 418 subjects (174 IGD; 244 recreational game use (RGU)). Resting-state fMRI data were collected and functional connectivity analyses performed based on ventral dorsal seeds. Correlations follow-up spectrum...

Although internet gaming disorder (IGD) has been included in the DSM-5 for approximately 10 years, debate remains regarding its existence and classification.

Abstract Background Internet gaming disorder (IGD) is a type of behavioral addiction characterized by poorly controlled and interfering patterns game playing. Studies have suggested that the IGD usually accompanied increased desire or craving for gaming, suggesting secondary rewards related to may become more salient than those primary like food. However, this hypothesis has not been formally tested potential neural mechanisms remain unclear. Methods This functional magnetic resonance...

Studies have shown that people with internet gaming disorder (IGD) exhibit impaired executive control of cravings; however, the neural mechanisms underlying this process remain unknown. In addition, these conclusions were based on hypothesis brain networks are temporally static, neglecting dynamic changes in cognitive processes.Resting-state fMRI data collected from 402 subjects [162 IGD and 240 recreational game users (RGUs)]. The community structure (recruitment integration) network (ECN)...

Abstract Background Craving‐related brain responses have been associated with the emergence and maintenance of addictions. However, little is known about network organizations underlying cravings in internet gaming disorder (IGD). Methods Sixty‐six IGD subjects 61 matched individuals recreational game use (RGU) were scanned while performing a cue‐craving task. A recently developed whole‐brain analysis approach, connectome‐based predictive modelling (CPM) leave‐one‐out cross‐validation was...

Abstract Cross‐sectional studies have suggested that functional heterogeneity within the striatum in individuals with addictive behaviours may involve transition from ventral to dorsal partitions; however, due limitations of cross‐sectional design, whether contribution this addiction was confused by individual differences remains unclear, especially for internet gaming disorder (IGD). Longitudinal magnetic resonance imaging (fMRI) data 22 IGD subjects and 18 healthy controls were collected...

Studies have shown that internet gaming disorder (IGD) has the potential to be a type of addiction; however, direct comparisons (similarities and differences) between IGD traditional addictions remain scarce, especially at neuroimaging level. Resting-state functional magnetic resonance imaging (fMRI) data were collected from 92 individuals with IGD, 96 tobacco use disorders (TUDs) 107 who served as healthy controls (HCs). Independent component analysis (ICA) was performed explore...

Abstract Background Mitochondrial ribosomal protein S2 ( MRPS2 ) gene mutation, which is related to severe hypoglycemia and lactic acidosis, rarely reported globally. Case presentation We report a case of new mutation in Chinese girl who presented with acidosis. A homozygous C.412C > G variant that could cause complex oxidative phosphorylation deficiency had not been before was identified. The clinical manifestations included recurrent vomiting, hypoglycemia, sensorineural hearing loss,...

The functional connectivity within and between networks could provide a framework to characterize the neurobiological mechanism of nicotine addiction. This study examined brain regions that were functionally connected in response smoking cues established brain-behaviour relationships smokers. Sixty-seven male smokers enrolled scanned while performing cue-reactivity Stroop task. A whole-brain analysis approach, connectome-based predictive modelling (CPM), was conducted on data from task...

Abstract Background Impulsivity and decision-making are key factors in addiction. However, little is known about how gender time sensitivity affect impulsivity internet gaming disorder (IGD). Objective To investigate the difference of impulsive relevant brain responses IGD. Methods We conducted a functional magnetic resonance imaging (fMRI) study with 123 participants, including 59 IGD individuals (26 females) 64 matched recreational game users (RGUs, 23 females). Participants performed...

Abstract Background Autism spectrum disorder (ASD) is characterized by social and behavioural deficits. Current diagnosis relies on criteria, but machine learning, particularly connectome-based predictive modelling (CPM), offers the potential to uncover neural biomarkers for ASD. Objective This study aims predict severity of ASD traits using CPM explores differences among subtypes, seeking enhance understanding Methods Resting-state functional magnetic resonance imaging data from 151...

Objective To analyze the clinical characteristics and prognosis of congenital solitary kidney in 9 children to find causes renal impairment factors associated with prognosis. Methods The data Beijing Children's Hospital Affiliated Capital Medical University were analyzed, retrospectively.Data long-term collected through follow-up study. Results Five girls 4 boys involved analysis, ranging from 3.9 16.0 years old.The mean inpatient age was 9.9 years-old.The patients showed...

Abstract Background Studies have shown that people with internet gaming disorder (IGD) show impaired executive control over their cravings; however, the neural mechanisms underlying this process remain unknown. In addition, these conclusions were based on hypothesis brain networks temporally stationary and neglected changes in cognitive processes. Methods Resting-state fMRI data collected from 402 subjects (162 IGD 240 recreational game users (RGUs)). The community structure (recruitment...

ABSTRACT Background Changes in the brain’s default mode network (DMN) resting state are closely related to autism spectrum disorder (ASD). Module segmentation can effectively elucidate neural mechanism of ASD and explore intra- internetwork connections by means participation coefficient (PC). Methods Resting-state fMRI data from 269 patients 340 healthy controls (HCs) were used current study. The PC brain modules was calculated compared between subjects HCs. In addition, we further explored...

Objective To investigate the emotional state and its influencing factors in children with nocturnal enuresis, so as to improve clinical attention give appropriate intervention. Methods Totally 166 enuresis patients aged 9-15 years old were admitted Beijing Children's Hospital Affiliated Capital Medical University from August 2011 2014.Specifically, Screen for Child Anxiety Related Emotional Disorders (SCARED) Depressive Self-Rating Scale Childhood (DSRSC) utilized test patients'...

Objective To explore the therapy efficacy for children with primary nocturnal enuresis by meta-analysis on efficiency of alarm treatment versus desmopressin. Methods PubMed, Central, Elesvier, CNKI and some other databases were browsed to obtain all randomized controlled trails(RCT) compare between desmopressin.Data extraction quality evaluation done methods recommended Cochrane center.The results short-term long-term compliance analyzed Review Manager 5.0. Results Fifty-four...

Primary nocturnal enuresis is a common childhood disorder, increasingly seen as part of heterogeneous phenomenon.Nocturnal polyuria, overactive bladder, high arousal thresholds and genetics are in various combinations, central to pathogenesis.Psychiatric problems also play important roles the pathogenesis primary enuresis.There still underlying pathophysiological mechanisms be discussed researched. Key words: Primary enuresis; Pathogenesis; Child

Abstract Background Animal models suggest transitions from non-addictive to addictive behavioral engagement are associated with ventral-to-dorsal striatal shifts. However, few studies have examined such features in humans, especially internet gaming disorder (IGD), a addiction. Methods Four-hundred-and-eighteen subjects (174 IGD; 244 recreational game use (RGU)) were recruited. Resting-state fMRI data collected and functional connectivity (FC) analyses performed based on ventral dorsal...