A5053584291- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Reproductive tract infections research
- Complement system in diseases
- Reproductive System and Pregnancy
- Microbial infections and disease research
- Rabies epidemiology and control
- Vector-Borne Animal Diseases
- Immune Response and Inflammation
- Yersinia bacterium, plague, ectoparasites research
- Platelet Disorders and Treatments
- Virus-based gene therapy research
- Extracellular vesicles in disease
- Drug Transport and Resistance Mechanisms
- Inflammation biomarkers and pathways
- Malaria Research and Control
- Herpesvirus Infections and Treatments
- Cervical Cancer and HPV Research
- Urinary Tract Infections Management
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Hypoxia, and Metabolism
- Blood groups and transfusion
- Dermatology and Skin Diseases
Friedrich-Loeffler-Institut
2018-2023
University of Veterinary Medicine Hannover, Foundation
2019
Malaria represents a major cause of death from infectious disease. Hemozoin is Plasmodium-derived product that contributes to progression cerebral malaria. However, there gap knowledge regarding how hemozoin recognized by innate immunity. Myeloid C-type lectin receptors (CLRs) encompass family carbohydrate-binding act as pattern recognition in In the present study, we identify CLR CLEC12A receptor for hemozoin. Dendritic cell-T cell co-culture assays indicate CLEC12A/hemozoin interaction...
An inactivated Coxiella burnetii Phase I (PhI) vaccine (Coxevac®) is licensed in several European countries for goats and cattle to prevent coxiellosis. The also applied sheep, although detailed information about the ovine immune response dose missing. Eighteen gimmers from a C. unsuspected flock were randomly divided into three groups of six. Group 1 (Cox1) 2 (Cox2) vaccinated twice with ml Coxevac®, respectively, weeks apart (primary vaccination). same procedure was Cox3 (2 sodium...
Intracellular bacterial pathogens often undergo a life cycle in which they parasitize infected host cells membranous vacuoles. Two pathways have been described by chlamydia can exit cells: lytic cell destruction or via extrusion formation.
A Q fever outbreak on a dairy goat and cattle farm was investigated with regard to the One Health concept. Serum samples vaginal swabs from goats different reproductive statuses were collected. Cows, cats, dog same sample matrix. The farmer’s family examined by serum samples. Ruminant sera analyzed two phase-specific enzyme-linked immunoassays (ELISAs). Dominant immunoglobulin G (IgG) phase II levels reflected current infections in goats. cows had high IgG I indicating ongoing infections....
Dendritic cells (DCs) and natural killer (NK) are critically involved in the early response against various bacterial microbes. Functional activation of infected DCs NK cell-mediated gamma interferon (IFN-γ) secretion essentially contribute to protective immunity Chlamydia How cooperate during antichlamydial is not fully understood. Therefore, present study, we investigated functional interplay between Chlamydia-infected cells. Our biochemical cell biological experiments show that...
We present a new and straightforward method by which standard cell culture plates can be sealed off from ambient air placed under controlled hypoxic conditions without costly or highly specialized materials. The was established on murine system using the dendritic line JAWS II but readily adapted to other cultures. procedure designed easy implement in laboratories with incubators requires only available materials, resources, consumables, such as six-well plates, degassed medium, CoCl2,...
Natural killer (NK) cells are innate immune critically involved in the early response against various pathogens including chlamydia. Here, we demonstrate that chlamydia-infected NK prevent intracellular establishment and growth of bacteria. Upon infection, they display functional maturation characterized by enhanced IFN-γ secretion, CD146 induction, PKCϴ activation, granule secretion. Eventually, chlamydia released a non-infectious, highly immunogenic form driving potent Th1 response....
Dendritic cells (DCs) belong to the first line of innate defense and come into early contact with invading pathogens, including zoonotic bacterium Coxiella burnetii, causative agent Q fever. However, pathogen-host cell interactions in C. burnetii-infected DCs, particularly role mechanisms immune subversion beyond virulent phase I lipopolysaccharide (LPS), as well contribution cellular self-defense strategies, are not understood. Using II Coxiella-infected we show that impairment DC...
Erythrocytes (E) express complement receptor, type 1 (CR1, CD35), by which they bind opsonized immune complexes (IC) in competition with leucocytes expressing higher numbers of CR1 as well other complement‐ and Fc‐receptors. This may prevent inappropriate activation phagocytic cells. We examined the distribution on whole blood cells preformed tetanus toxoid (TT)/human anti‐TT IC, situ 80% autologous serum. Binding to E occurred rapidly reflected kinetics C3‐fragment incorporation into IC....
Natural killer (NK) cells are critically involved in the early immune response against various intracellular pathogens, including Coxiella burnetii and Chlamydia psittaci . -infected NK functionally mature, induce cellular immunity, protect themselves by killing bacteria secreted granules. Here, we report that infected do not allow multiday growth of , as is usually observed other host cell types.
Q-Fieber ist eine weltweit verbreitete Zoonose, die durch Coxiella (C.) burnetii verursacht wird. Dieses Bakterium wird besonders uber Geburtsmaterial infizierter kleiner Wiederkauer in grosen Mengen ausgeschieden, aber auch Milch, Kot und Urin. Der Hauptinfektionsweg fur Mensch Tier Inhalation von erregerhaltigen Aerosolen. Bei der Verbreitung spielen Wind andere meteorologische Faktoren Rolle. Auch Zecken wie Dermacentor spp. Ixodes ricinus konnten Bedeutung bei Ubertragung C. haben....