A5062813451- Vector-borne infectious diseases
- Viral Infections and Vectors
- Yersinia bacterium, plague, ectoparasites research
- Vector-Borne Animal Diseases
- Bacillus and Francisella bacterial research
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Poxvirus research and outbreaks
- Bacteriophages and microbial interactions
- Rabies epidemiology and control
- Insect and Pesticide Research
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
- Microbial infections and disease research
- Brucella: diagnosis, epidemiology, treatment
- Plant Virus Research Studies
- Disaster Response and Management
- Travel-related health issues
- Genomics and Phylogenetic Studies
- Toxoplasma gondii Research Studies
- Burkholderia infections and melioidosis
- Identification and Quantification in Food
- Aquaculture disease management and microbiota
- Monoclonal and Polyclonal Antibodies Research
- Immune responses and vaccinations
Bundeswehr Medical Service Academy
2020-2024
Universität der Bundeswehr München
2012-2023
Institut für Mikrobiologie der Bundeswehr
2012-2023
Bundeswehr Joint Medical Service
2021
Czech Academy of Sciences, Institute of Microbiology
2013-2015
University Hospital Regensburg
2014
Northern Arizona University
2014
Aschaffenburg University of Applied Sciences
2009
Veterinary and Agrochemical Research Centre
2009
Justus-Liebig-Universität Gießen
1994
Coxiella burnetii is an intracellular bacterial pathogen that causes Q fever. Infected pregnant goats are a major source of human infection. However, the tissue dissemination and excretion pathway in still poorly understood. To better understand fever pathogenesis, we inoculated groups via intranasal route with recent Dutch outbreak C. isolate. Tissue were followed for up to 95 days after parturition. Goats successfully infected route. PCR immunohistochemistry showed strong tropism towards...
Hyalomma marginatum and rufipes are two-host tick species, which mainly distributed in southern Europe, Africa middle-eastern Asia. They well-known vectors of Crimean Congo hemorrhagic fever (CCHF) virus other viruses as well Rickettsia aeschlimannii. In recent years, these species have been found sporadically Germany, but they do not belong to the autochthonous fauna Germany.Ticks with unusual morphology were collected sent from private persons or public health offices involve institutions...
Abstract Background Coxiella burnetii , the causative agent of Q fever, has a wide host range. Few epidemiological tools are available, and they often expensive or not easily standardized across laboratories. In this work, C. isolates from livestock ticks were typed using infrequent restriction site-PCR (IRS-PCR) multiple loci variable number tandem repeats (VNTR) analysis (MLVA). Results By applying IRS-PCR, 14 could be divided into six groups containing up to five different isolates....
The objective of the present study was to establish a system real-time polymerase chain reactions (PCRs) for specific detection Yersinia pestis using LightCycler (LC) instrument. Twenty-five strains Y. pestis, 94 other species and 33 clinically relevant bacteria were investigated. Assays 16S rRNA gene target plasminogen activator (resides on 9.5-kb plasmid) murine toxin fraction 1 antigen (both 100-kb combined use in two multiplex assays including an internal amplification control detecting...
Coxiella burnetii is the causative agent of Q-fever, a widespread zoonosis. Due to its high environmental stability and infectivity it regarded as category B biological weapon agent. In domestic animals infection remains either asymptomatic or presents infertility abortion. Clinical presentation in humans can range from mild flu-like illness acute pneumonia hepatitis. Endocarditis represents most common form chronic Q-fever. serology gold standard for diagnosis but inadequate early case...
Tularemia is a rare, notifiable zoonosis in Germany. Since November 2004, several lines of evidence including outbreaks humans or animals and confirmed infections indigenous hare rodent populations have indicated re-emergence tularemia different German federal states. Unfortunately, reliable basic information on the seroprevalence geographical regions, permitting identification risk factors, does not exist. Combining sensitive screening assay with highly specific confirmative immunoblot...
The main reservoir of Coxiella (C.) burnetii are ruminants. They shed the pathogen through birth products, vaginal mucus, faeces and milk. A direct comparison C. excretions between naturally infected sheep goats was performed on same farm to investigate species-specific differences. animals were vaccinated with an inactivated phase I vaccine at beginning study period for public health reasons. Vaginal rectal swabs along milk specimens taken monthly during lambing once again next season. To...
Blood cultures from a heroin user who died in June 2012, few hours after hospital admission, due to acute septic disease, revealed the presence of Bacillus anthracis. This report describes extended diagnosis by MALDI-TOF and real-time PCR rapid confirmation anthrax infection through reference laboratories. Physicians diagnostic laboratories were informed alerted efficiently reporting channels German public health institutions, which is essential for prevention further cases.
A Q fever outbreak on a dairy goat and cattle farm was investigated with regard to the One Health concept. Serum samples vaginal swabs from goats different reproductive statuses were collected. Cows, cats, dog same sample matrix. The farmer’s family examined by serum samples. Ruminant sera analyzed two phase-specific enzyme-linked immunoassays (ELISAs). Dominant immunoglobulin G (IgG) phase II levels reflected current infections in goats. cows had high IgG I indicating ongoing infections....
Q fever is caused by the obligate intracellular bacterium Coxiella burnetii. In vitro growth of usually limited to viable eukaryotic host cells imposing experimental constraints for molecular studies, such as identification and characterisation major virulence factors. Studies pathogenicity may benefit from recent development an extracellular medium C. However, it crucial investigate consistency phenotype strains propagated two fundamentally different culturing systems. present study, we...
Ticks are transmitting a wide range of bacterial pathogens that cause substantial morbidity and mortality in domestic animals. The full pathogen burden transmitted by tick vectors is incompletely studied many geographical areas, extensive studies required to fully understand the diversity distribution ticks. We sampled 824 ticks 11 species collected 19 counties Romania. were mainly from dogs, but also other wild animals, subjected molecular screening for pathogens. Rickettsia spp. was most...
SUMMARY Q fever is a notifiable disease in Germany. The majority of the reported cases are related to outbreaks. objective our study was evaluate general role community-acquired pneumonia (CAP). We investigated respiratory samples and sera from 255 patients with CAP, who were enrolled into CAPNETZ cohort summer 2005. Altogether, data showed significant prevalence as CAP (3·5%). If patient's condition leads diagnostic test for Chlamydophila sp., Mycoplasma sp. or Legionella then should also...