A5083083284- Breast Cancer Treatment Studies
- Respiratory Support and Mechanisms
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Long-Term Effects of COVID-19
- HER2/EGFR in Cancer Research
- Mechanical Circulatory Support Devices
- Pneumothorax, Barotrauma, Emphysema
- Cardiac Arrest and Resuscitation
- Trauma Management and Diagnosis
- Anesthesia and Pain Management
- Muscle and Compartmental Disorders
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Pleural and Pulmonary Diseases
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Airway Management and Intubation Techniques
- Organ Donation and Transplantation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Enhanced Recovery After Surgery
- Electrolyte and hormonal disorders
- Abdominal Surgery and Complications
- Dental Anxiety and Anesthesia Techniques
Ospedale Policlinico San Martino
2025
Ospedale “M. Bufalini” di Cesena
2020-2023
Ospedale Valduce
2005-2023
University of Modena and Reggio Emilia
2022
E Ink (South Korea)
2022
Ospedale Infermi di Rimini
2022
Azienda-Unita' Sanitaria Locale Di Cesena
2017-2021
University of Messina
2020
Azienda Ospedaliera di Valtellina e Valchiavenna
2007
Non-invasive ventilation (NIV) is a widely used treatment for neonatal respiratory distress syndrome (RDS). Data on diaphragm contractility and thickness during NIV scarce. We aimed to describe changes in thickness/contractility explore associations with discontinuation failure. This single-center prospective study. Diaphragmatic ultrasound was performed weekly NIV, then within 7 days from discontinuation. Diaphragm measured at end-inspiration (DTI) end-expiration (DTE). thickening fraction...
Clinicopathological prognostic features have limited value to identify with precision newly diagnosed patients hormone receptor (HR)-positive, HER2-negative breast cancer (BC), who would benefit from chemotherapy (CT) in addition adjuvant hormonal therapy (HT). The 21-gene Oncotype DX Breast Recurrence Score
To test the hypothesis that bonding with a blue light-emitting diode (LED) curing unit produces no more failures in adhesive-precoated (APC) orthodontic brackets than carried out by conventional halogen lamp.Sixty-five patients were selected for this randomized clinical trial, which total of 1152 stainless steel APC employed. In order to carry valid comparison bracket failure rate following use each type unit, patient's mouth was divided into four quadrants. 34 randomly patients, designated...
Bisulli, Marcello MD; Gamberini, Emiliano Coccolini, Federico Scognamiglio, Giovanni Agnoletti, Vanni MD Author Information
Evidence on the management and treatment of male breast cancer is scant. We report analysis a multicenter Italian series patients with treated eribulin. To our knowledge, this first use or eribulin in setting.Patients were retrospectively identified 19 reference centers. All received treatment, according to standard practice each center. Data collected using standardized form then centrally reviewed by two experienced oncologists.A total 23 (median age, 64 years; range, 42-80) considered....
Abstract Purpose Triple-negative breast cancer (TNBC) represents a subtype of which lacks the expression oestrogen receptor (ER), progesterone (PR) and human epidermal growth factor receptor-2 (HER2): TNBC accounts for approximately 20% newly diagnosed cancers is associated with younger age at diagnosis, greater recurrence risk shorter survival time. Therapeutic options are very scarce. Aim present analysis to provide further insights into clinical activity metronomic chemotherapy (mCHT), in...
Rhabdomyolysis is an uncommon complication of the coronavirus disease 2019 (COVID-19) infection. Previous reports have described its management and treatment in medical units, but not discussed confirmatory tests or differential diagnosis. We report a case 58 year-old male patient, who was admitted for COVID-19 pneumonia subsequently developed severe weakness, inability to move limbs, acute renal failure, significantly elevated myoglobin creatinine kinase, diagnosed with rhabdomyolysis....
This study was conceived to provide systematic data about lung mechanics during early phases of CoVID-19 pneumonia, as long explore its variations prone positioning.We enrolled four patients hospitalized in the Intensive Care Unit "M. Bufalini" hospital, Cesena (Italy); after positioning an esophageal balloon, we measured mechanical power, respiratory system and transpulmonary parameters arterial blood gases every 6 hours, just before decubitus change 1 hour prono-supination.Both compliance...
Abstract Nowadays, treatment of metastatic breast cancer (MBC) has been enriched with novel therapeutical strategies. Metronomic chemotherapy (mCHT) is a continuous and frequent administration at lower dose so whit less toxicity. Thus, this strategy could be attractive for elderly MBC patients. Aim analysis to provide insights into mCHT’s activity in real-life setting Data patients ≥ 75 years old included VICTOR-6 study were analyzed. multicentre, Italian, retrospective study, which...
Even with encouraging recipient outcomes, transplantation using donation after circulatory death (DCD) is still limited. A major barrier to this type of the consequences warm ischemia on graft survival; however, preservation techniques may reduce cardiac arrest and provide better organ conservation. Furthermore, DCD in trauma patients could further expand donation. We present five cases which organs were retrieved transplanted successfully normothermic regional perfusion (NRP) patients....
770 Background: Epirubicin and Vinorelbine alone or in combination are considered active ABC.The optimal duration of a chemotherapic treatment ABC patients is not know. Otherwise has limiting-dose due to its own toxicity. Methods: In this multicenter phase II study we analyzed the feasibility efficacy 6 cycles i.v. EV, followed, responder-patients, by oral VNR alone. Our preliminary results referred 26 with advanced recurrence breast cancer (21 ER +) treated first-line 75 mg/m2 die 1 25 1–8,...
Tracheostomy is one of the most performed procedures in intensive care unit. Dilatational techniques, such as those described by Ciaglia, Griggs, or Fantoni, are currently best choices they can be easily at bedside. Like any other intervention, early and late complications occur even if procedure appears to without issues. Although using a bronchoscope make tracheostomy easier safer, its routine utilization remains controversial. We describe new method further reduce incidence some...
A total of 1095 patients with operable breast cancer and en-rolled in a randomized clinical trial were analysed for estrogen (ER) progesterone (PgR) receptor content their primary tumor, the relationships between steroid status several epidemiologic characteristics studied. The proportion ER+ median ER levels increased age: compared to women younger than 40, those aged 66 or more approximately three times likely have an tumor (OR = 3.0, 95% C.I. 1.6–5.7). This difference tended be marked...
Epirubicin and vinorelbine are considered active drugs in metastatic breast cancer. The optimal duration of a chemotherapy regimen for cancer patients is still unknown. Nevertheless, epirubicin has dose-limiting cardiotoxicity. Vinorelbine also available as oral formulation. In multicenter phase II study, we analyzed the feasibility efficacy maximum six cycles i.v. plus vinorelbine, followed by vinorelbine. We enrolled 30 with Each patient received (75 mg/m2 on day 1) (25 days 1-8), every 3...
Epirubicin and vinorelbine are considered active drugs in metastatic breast cancer. The optimal duration of a chemotherapy regimen for cancer patients is still unknown. Nevertheless, epirubicin has dose-limiting cardiotoxicity. Vinorelbine also available as oral formulation. In multicenter phase II study, we analyzed the feasibility efficacy maximum six cycles i.v. plus vinorelbine, followed by vinorelbine. We enrolled 30 with Each patient received (75 mg/m 2 on day 1) (25 days 1–8), every 3...
The aim of this study is to explore risk factors for in-hospital mortality and describe the effectiveness different treatment strategies 205 laboratory-confirmed cases infected with SARS-CoV-2 during Lombardy outbreak. All patients received best supportive care specific interventions that included main drugs being tested repurposing treat COVID-19, such as hydroxychloroquine, anticoagulation antiviral drugs, steroids, interleukin-6 pathway inhibitors. Clinical, laboratory, characteristics...
e12552 Background: mCHT is the minimum biologically effective dose of a chemotherapeutic agent, given at regular dosing regimen with no prolonged drug free interval, that leads to anti-tumor activity. Old regimens included Cyclophosphamide-Methotrexate (CM), whereas in last years new regimens, such as Vinorelbine (VRL) and Capecitabine (CAPE)-based have been developed. Aim this observational retrospective ongoing study describe use ABC pts across 5 clinical characteristics together efficacy...
Abstract: Major trauma is one of the most common causes death in western world young population (15–25 years). Thoracic represents 25% traumatic deaths, and incidence tracheobronchial injuries literature lower than 5%. Nevertheless, airway are life-threatening conditions. Here we present a case 25-year-old patient who underwent severe motorcycle crash. The injury severity score (ISS) was 35 at admission to hospital. A right middle bronchus laceration <2 cm involving whole thickness wall...
Abstract Since its outbreak, in January, 2020, it has been clear that CoVID-19 pneumonia is atypical. Despite a full concordance to Berlin criteria for Acute Respiratory Distress Syndrome (ARDS), respiratory system mechanics preserved [1]. Mechanical ventilation and muscular paralysis are recommended worsening insufficiency [2]; substantial number of cases, prone positioning significantly improves oxygenation.
A 55-year-old patient experiencing severe coronavirus disease 19 (COVID-19) related acute refractory respiratory failure requiring venovenous extracorporeal membrane oxygenation (VV-ECMO) support, with femoro-femoral approach, suddenly developed both signs of drainage and return obstruction, blood flow (EBF) inconsistency, evolving to impairment, at the same time desaturation, hemodynamic instability. To support differential diagnosis, a focused point care lung ultrasound was performed,...
ABSTRACT Importance With randomized clinical trials ongoing and vaccine still a long distance away, efforts to repurpose old medications used for other diseases provide hope the treatment of COVID-19 Objectives To examine risk factors in-hospital mortality describe effectiveness different strategies in real-life setting patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. Design Real-life single-center study during Lombardy outbreak. Setting Valduce Hospital...